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RPL26 and nucleolin play critical roles in controlling the production of p53

Investigators at St. Jude Children's Research Hospital have discovered a previously unrecognized mechanism that controls a key protein linked to the cell's response to stress - a finding that holds promise for new ways to enhance cancer therapies or protect cells from dying after exposure to damaging chemicals or radiation.

9 Oct 2005

New data demonstrates how CA4P has anti-tumor and anti-angiogenic activity

Anti-angiogenic agents have been successful in the clinic for blocking the growth of solid tumors. However, these agents used in combination with chemotherapy have improved the survival of patients with cancers by only several months.

9 Oct 2005

Gut antibody could prove to be a promising drug target for Crohn's disease

A collaboration led by the Burnham Institute for Medical Research has found that an antibody which binds to an unusual sugar molecule residing in the gut halts the inflammation seen in Crohn's disease and other intestinal inflammations. The antibody could prove to be a promising drug target for these common chronic intestinal disorders.

9 Oct 2005

New information regarding the genetic, cellular and neurological bases of susceptibility to autism and schizophrenia

Two New Jersey research teams are reporting discoveries about the biological nature of psychiatric disorders that may bring them closer to the ultimate goal of finding cures for complex diseases, such as autism and schizophrenia.

9 Oct 2005

Novel methodology that can be used to investigate choice and introspection

When evaluating facial attractiveness, participants may fail to notice a radical change to the outcome of their choice, according to a study by researchers at Lund University, Sweden, and New York University. Equally surprising, the study shows that participants may produce confabulatory reports when asked to describe the reasons behind their choices.

9 Oct 2005

Deadly 1918 Spanish flue virus has been reconstructed and characterized

This research, reported in this week's issue of Science, is part of a larger research initiative being led by Adolfo Garcia-Sastre, PhD, Professor of Microbiology and Peter Palese, PhD, Professor and Chairman of Microbiology at Mount Sinai School of Medicine.

5 Oct 2005

Fruits and vegetables can increase or decrease the activity and toxicity of orally-administered drugs

Eating fruits and vegetables is essential to living a long and healthy life, yet research has shown they can cause dangerous interactions with medicines.

5 Oct 2005

Particular versions of the TGFb1 gene are largely responsible for how badly the illness affects patients' lungs

Subtle differences in other genes -- besides the defective gene known to cause the illness cystic fibrosis -- can significantly modify the inherited disease's severity, a large new multi-center national study has concluded.

5 Oct 2005

Cells inside the hair follicle are true multipotent stem cells

Using an animal model, a research team led by Yann Barrandon at the EPFL (Ecole Polytechnique Federale de Lausanne) and the CHUV (Lausanne University Hospital) has discovered that certain cells inside the hair follicle are true multipotent stem cells, capable of developing into the many different cell types needed for hair growth and follicle replacement.

5 Oct 2005

The cocktail party problem

Known as "the cocktail party problem," the ability of the brain's auditory processing centers to sort a babble of different sounds, like cocktail party chatter, into identifiable individual voices has long been a mystery.

5 Oct 2005

Most comprehensive picture to date of how influenza viruses evolve and are transmitted

In the first large-scale effort of its kind, researchers have determined the full genetic sequence of more than 200 distinct strains of human influenza virus.

5 Oct 2005

Richness of motor training determines not only what we learn but how we learn

Practice makes perfect when people learn behaviors, from baseball pitching to chess playing to public speaking. Biomedical engineers at Washington University in St. Louis have now identified how people use individual experiences to improve performance.

5 Oct 2005

Math1 gene plays a pivotal role in the formation of many of the neurons important in hearing and balance

Close your eyes and imagine you are in a darkened Carnegie Hall. Although it's pitch black, you know you are getting closer to the stage as the music gets louder. If you have been there before, you have a sense of the location of the seats and aisles.

5 Oct 2005

GRK5 protein plays important role in hypertension

Researchers at Jefferson Medical College have implicated a protein called GRK5 as having an important role behind essential hypertension, which affects more than 65 million Americans.

5 Oct 2005

Cells have developed a surprising transportation system for their endosomes

...according to research published today in Physical Review Letters, "Dynamics and Spatial Organization of Endosomes in Mammalian Cells."

5 Oct 2005

Somatic adult stem cell niches - key regulators of stem cell activity in mammary tissue

Researchers at Georgetown's Lombardi Comprehensive Cancer Center have found that the onset of breast cancer may be due to defects in somatic adult stem cell niches that exist long before tumors develop.

4 Oct 2005

Researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model

The first close-up look at a pro-inflammatory signaling molecule involved in immune response in mammals suggests that researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model, scientists say.

4 Oct 2005

Amiloride and spironolactone may help patients with high blood pressure

Two inexpensive but widely overlooked drugs may help many patients who continue to have high blood pressure despite taking standard blood pressure medications, according to research by Indiana University School of Medicine scientists.

4 Oct 2005

Divalent metal transporter-1 decreases metal-related injury in the lung

Multi-vitamin products, nutritional supplements and parents tout the need for such mineral elements as calcium, zinc, phosphorus, iron and others.

4 Oct 2005

Community-level intervention program successfully delayed sexual debut and increased the use of condoms

A community-level intervention program aimed at young adolescents delays early intercourse, increases condom use and reduces the type of risky sexual behavior that can result in sexually transmitted diseases and HIV/AIDS, a Yale researcher reports in AIDS.

4 Oct 2005

Medical Research News

RPL26 and nucleolin play critical roles in controlling the production of p53

New data demonstrates how CA4P has anti-tumor and anti-angiogenic activity

Gut antibody could prove to be a promising drug target for Crohn's disease

New information regarding the genetic, cellular and neurological bases of susceptibility to autism and schizophrenia

Novel methodology that can be used to investigate choice and introspection

Deadly 1918 Spanish flue virus has been reconstructed and characterized

Fruits and vegetables can increase or decrease the activity and toxicity of orally-administered drugs

Particular versions of the TGFb1 gene are largely responsible for how badly the illness affects patients' lungs

Cells inside the hair follicle are true multipotent stem cells

The cocktail party problem

Most comprehensive picture to date of how influenza viruses evolve and are transmitted

Richness of motor training determines not only what we learn but how we learn

Math1 gene plays a pivotal role in the formation of many of the neurons important in hearing and balance

GRK5 protein plays important role in hypertension

Cells have developed a surprising transportation system for their endosomes

Somatic adult stem cell niches - key regulators of stem cell activity in mammary tissue

Researchers "should rethink what they are doing" in creating drugs based on a fruit-fly model

Amiloride and spironolactone may help patients with high blood pressure

Divalent metal transporter-1 decreases metal-related injury in the lung

Community-level intervention program successfully delayed sexual debut and increased the use of condoms

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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