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New antibody drug conjugates can transform early HER2-positive breast cancer treatment

In a landmark moment at the ESMO Congress 2025, pivotal studies have unveiled compelling evidence that a new class of anti-cancer agents-antibody-drug conjugates (ADCs)-can dramatically improve outcomes for patients with early-stage HER2-positive breast cancer.

18 Oct 2025

Nanoparticles offer new hope for treating alcohol-related liver disease

Across the world, more than 1.5 billion people suffer from chronic liver disease. The U.S. Centers for Disease Control and Prevention reports that it kills more than 52,000 people a year in the United States alone - the ninth most common cause of death in the nation.

17 Oct 2025

Nanoplastics with environmental coatings can sneak past the skin's defenses

Plastic is ubiquitous in the modern world, and it's notorious for taking a long time to completely break down in the environment - if it ever does.

17 Oct 2025

Study reveals how a microglial mutation increases risk for Alzheimer's disease

Dominika Pilat, PhD, and Ana Griciuc, PhD, of the Department of Neurology at Massachusetts General Hospital are the lead and senior authors of a paper published in Neuron, "The Gain-of-Function TREM2-T96K Mutation Increases Risk for Alzheimer's Disease by Impairing Microglial Function."

17 Oct 2025

Study highlights the emotional and social challenges of stroke recovery

Nirupama Yechoor, MD, MSC, of the Department of Neurology at Massachusetts General Hospital, is the senior author of a paper published in JAMA Network Open, "Coherence of Stroke Survivors' Lived Experiences and the Stroke Specific Quality of Life Scale."

17 Oct 2025

European societies launch EndoCompass to guide the future of endocrine research

The European Society for Endocrinology (ESE) and the European Society for Paediatric Endocrinology (ESPE) have released today, 17 October 2025, the EndoCompass Research Roadmap: Directions for the Future of Endocrine Science.

17 Oct 2025

CRATERs identified as key sites for T cell-mediated tumor destruction

Like the surface of the moon, new research published today in Cell finds the existence of craters on the surface of melanoma cells that serve as immune hubs, becoming major sites for tumor killing. These craters could serve as good markers for immunotherapy success.

17 Oct 2025

Supportive signals during pregnancy ease return-to-work transition for women

Returning to work after maternity leave can leave new mothers wrestling with guilt – feeling they can't fully win at work or home.

17 Oct 2025

Researchers achieve proof of concept for generating eggs from somatic cells

Researchers at Oregon Health & Science University have accomplished a unique proof of concept to treat infertility by turning skin cells into eggs capable of producing early human embryos.

17 Oct 2025

Review reveals how paternal lifestyle shapes sperm epigenetics and offspring health

A new review in Clinical Epigenetics synthesises growing evidence that paternal lifestyle and environmental exposures such as diet, obesity, smoking, endocrine-disrupting chemicals, and stress alter sperm epigenetic marks (DNA methylation, histone retention, and small non-coding RNAs).

17 Oct 2025

How task engagement reshapes the brain’s auditory processing

When we are engaged in a task, our brain's auditory system changes how it works. One of the main auditory centers of the brain, auditory cortex, is filled with neural activity that is not sound driven – rather, this activity times the task, each neuron ticking at a different moment during task performance.

17 Oct 2025

Research reveals how immune cells orchestrate the release of toxic granules

When immune cells strike, precision is everything. New research reveals how natural killer and T cells orchestrate the release of toxic granules – microscopic packages that destroy virus-infected or cancerous cells.

17 Oct 2025

Scientists discover why a powerful leukemia drug fails in most patients

Researchers from Rutgers Health and other institutions have discovered why a powerful leukemia drug eventually fails in most patients – and found a potential way to overcome that resistance.

17 Oct 2025

People's heart health unlikely to be affected by some industrially processed hard fats

Two types of industrially processed hard fats, widely used in everyday foods such as bakery products, margarines and spreads, are unlikely to affect heart health when consumed in levels achievable in most people's diets.

17 Oct 2025

Preexisting hyperlipidemia in pregnancy linked to obstetric and early heart risks

Preexisting hyperlipidemia in pregnancy is associated with heightened risks of obstetric complications and early cardiovascular events in the first five-years postpartum, according to a new study being presented at ACC's Cardio-Obstetrics Essentials: Team-Based Management of Cardiovascular Disease and Pregnancy conference.

17 Oct 2025