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Unlocking the potential of double negative memory B cells in cancer treatment

University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center scientists have discovered a novel subset of cancer-fighting immune cells that reside outside of their normal neighborhood – known as the tertiary lymphoid structure – where they become frustratingly dysfunctional when in close contact with tumors.

19 Feb 2025

Exploring ketamine's potential in the fight against treatment-resistant depression

Major depressive disorder (MDD) is a leading cause of disability worldwide, with a significant proportion of patients (10-20%) progressing to treatment-resistant depression (TRD).

19 Feb 2025

Mice study offers insight into how the brain balances risk and reward

Every day, our brain makes thousands of decisions, big and small. Any of these decisions - from the least consequential such as picking a restaurant to the more important such as pursuing a different career or moving to a new city - may result in better or worse outcomes.

19 Feb 2025

New therapeutic cocktails show promise for long-lasting asthma relief

Current asthma treatments don't work in all patients, and they don't provide long-term relief from potentially deadly asthma attacks.

19 Feb 2025

Newly discovered antigens could speed the development of potent cancer immunotherapies

Immune therapy has transformed how cancer is treated, but many tumors continue to evade these treatments, thanks to their resemblance to healthy tissue.

19 Feb 2025

Cancer cells cooperate to source nutrients and support tumor growth

Cancer cells work together to source nutrients from their environment-a cooperative process that was previously overlooked by scientists but may be a promising target for treating cancer.

19 Feb 2025

Genetic mutation linked to schizophrenia in both humans and mice

A genetic mutation found in two human patients with schizophrenia also increased schizophrenia-related behaviors in mice with the same mutation, a rare finding of a direct genetic link to psychosis, report researchers at the University of Illinois Urbana-Champaign and colleagues in Massachusetts and Germany.

19 Feb 2025

New HIV therapy lenacapavir shows high efficacy in Ugandan population

A multi-national, multi-institutional study led by Weill Cornell Medicine investigators found little natural resistance to a new HIV therapy called lenacapavir in a population of patients in Uganda.

19 Feb 2025

Simple text-messaging system saves time for cancer patients during treatment visits

Cancer patients spend a lot of time on their care. Meeting with doctors and other members of their health care team, getting labs and other tests, picking up prescriptions, and undergoing treatment all takes time.

19 Feb 2025

Ginger's furanodienone compound may offer new treatment for inflammatory bowel disease

An international team led by researchers at the University of Toronto has found a compound in ginger, called furanodienone (FDN), that selectively binds to and regulates a nuclear receptor involved in inflammatory bowel disease (IBD).

19 Feb 2025

Inflammation and metabolic syndrome contribute to prostate enlargement in aging men

A new research paper was published by Aging (Aging-US) on January 6, 2025, in Volume 17, Issue 1, titled "The profile of oxidative stress markers (arachidonic and linoleic acid derivatives) in patients with benign prostatic hyperplasia in relation to metabolic syndrome."

19 Feb 2025

Infant exposure to herpes virus may cause memory problems later in life

Very early exposure to even a very small dose of herpes simplex virus (HSV) in infant mice can lead to cognitive decline later in life, according to findings from a new Dartmouth-led study, in collaboration with Harvard Medical School and published in the journal PLoS Pathogens.

19 Feb 2025

F446L mutation in Lassa virus offers clues for new therapeutic approaches

Announcing a new article publication for Zoonoses journal. Lassa virus (LASV) glycoprotein complex (GPC) contains retained stable-signal peptide (SSP), glycoprotein 1 (GP1), and glycoprotein 2 (GP2).

19 Feb 2025

Hydrodissection may offer hope for post-amputation pain relief

A reliable method to treat post-amputation pain remains elusive, but a new Northwestern Medicine study conducted in collaboration with Ukrainian physicians suggests that hydrodissection - a simple procedure that injects fluid around nerves - may reduce residual limb pain and opioid dependence.

19 Feb 2025

New insights on cardiac rehabilitation for heart failure patients

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Cardiac rehabilitation (CR) remains an integral part of heart failure (HF) management, yet certain groups of patients with HF, particularly those with implantable devices, and those who are older and/or frail, are often precluded from CR.

19 Feb 2025