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New brain targets for GLP1-based obesity drugs may reduce weight without nausea

Researchers identified distinct hindbrain GLP1R neurons driving satiety and aversion, offering new targets for effective, side-effect-free obesity treatments.

14 Jul 2024

Groundbreaking mRNA vaccine administered to captive elephant to fight EEHV

Colossal, the de-extinction company, announces that the mRNA vaccine it helped to provide research support and acceleration funding for has been administered to the first elephant in captivity.

13 Jul 2024

Almirall's Ebglyss recommended by NICE for NHS atopic dermatitis patients

Almirall S.A., a global biopharmaceutical company dedicated to medical dermatology, announced today that the National Institute for Health and Care Excellence (NICE) has recommended Ebglyss (lebrikizumab) for use in moderate to severe Atopic Dermatitis in the NHS England.

13 Jul 2024

Study reveals potential cognitive benefits of antidiabetic drugs

Investigators analyzing the potential cognitive effects of antidiabetic medications in records of more than 1.5 million patients with type 2 diabetes mellitus (T2DM) found risks of dementia and Alzheimer's disease (AD) were significantly lower in patients treated with metformin and sodium glucose co-transporter-2 inhibitors (SGLT-2i) compared to other antidiabetic drugs.

12 Jul 2024

Light-activated drugs: A revolutionary approach in neuropathic pain treatment

Light can be used to activate drugs in specific parts of the body through photopharmacology.

11 Jul 2024

How Aloe vera's medicinal properties make it essential in medicine, cosmetics, and food products

Comprehensive review highlights Aloe vera's versatile biological activities and its potential applications in medicine and cosmetics while addressing its safety concerns.

11 Jul 2024

Repurposing pemafibrate to treat liver disease associated with metabolic disorders

The University of Barcelona has led a study that suggests using the drug known as pemafibrate to treat liver disease associated with metabolic disorders, the most common liver pathology in the world, which affects one in four people.

10 Jul 2024

Tirzepatide outperforms semaglutide in weight loss for overweight and obese adults

Tirzepatide leads to significantly greater weight loss than semaglutide in overweight or obese adults, with no significant difference in gastrointestinal adverse effects.

10 Jul 2024

60 years in the making: Nanoparticles revolutionize nucleotide delivery

Researchers trace the 60-year evolution of lipid nanoparticles (LNPs) for nucleic acid delivery, highlighting their potential to revolutionize gene therapy with safer and more effective treatments.

10 Jul 2024

Fungal endophytes: A promising frontier for breast cancer treatment

A recent study in Heliyon highlights the potential of fungal endophytes in developing novel anti-cancer agents, specifically targeting breast cancer therapy.

10 Jul 2024

Combined use of popular diabetes drugs likely to offer additional protection against heart and kidney disease

New research shows combined use of sodium glucose co-transporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP1-RAs) is likely to offer additional protection against heart and kidney disease in patients with diabetes.

8 Jul 2024

Semaglutide linked to increased risk of severe eye condition NAION in new study

Research shows semaglutide users face a significantly higher risk of developing non-arteritic anterior ischemic optic neuropathy (NAION) compared to users of other medications for diabetes and obesity.

8 Jul 2024

GLP-1 drugs found to lower cancer risk in diabetes patients

Research finds that GLP-1 receptor agonists significantly reduce the risk of 10 out of 13 obesity-associated cancers in type 2 diabetes patients compared to insulins, but show varied results against metformin.

8 Jul 2024

Semaglutide and very-low calorie diet combo shows superior results in managing type 2 diabetes

A study from the University of Nottingham shows that combining Semaglutide with a very-low calorie diet significantly improves weight loss and glycemic control in type 2 diabetes patients.

8 Jul 2024

Understanding the reach of pharmaceutical promotional events in healthcare

Promotional events sponsored by the pharmaceutical industry which target health professionals responsible for prescribing medications, such as physicians and nurse practitioners, are a key component of promotional campaigns for new drugs and devices.

8 Jul 2024

First-in-class oral drug improves embryo implantation and pregnancy outcomes in IVF

New research has demonstrated the effectiveness of a first-in-class oral, non-hormonal drug in increasing embryo implantation, pregnancy and live birth rates among infertile women who are undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).

8 Jul 2024

COVID-19 vaccination linked to reduced symptomatic child asthma

Researchers found that higher COVID-19 vaccination rates are linked to reduced asthma symptoms in children, highlighting broader health benefits of vaccination during the pandemic.

8 Jul 2024

Novel antiviral protein SAMD9L blocks HIV-1 and other lentiviruses

Researchers discovered that interferon-stimulated SAMD9L restricts HIV-1 and other lentiviruses by inhibiting viral translation and endosomal trafficking, while SAMD9 enhances HIV-1 replication.

7 Jul 2024

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, has successfully delivered the second preclinical candidate compound (PCC) in its collaboration with Fosun Pharma in June 2024, a potential innovative therapeutic using synthetic lethal strategy for the treatment of solid tumors.

5 Jul 2024

Novel compound amplifies naloxone's power to reverse overdoses

In a Stanford Medicine-led study, researchers combed through billions of compounds to find one that could enhance naloxone’s ability to fend off more potent opioids, with promising results in mice.

4 Jul 2024