Barrett's Esophagus

Barrett's Esophagus (BE) is a condition in which the normal lining of the lower part of the esophagus is replaced over time by another type of lining, normally present in the stomach.

What is Barrett's Esophagus?

Barrett's esophagus is a condition in which the flat, squamous cells lining the esophagus (food pipe) are replaced by columnar shaped cells resembling those present in the lining of the intestines. This change in the cellular lining is called metaplasia and is not usually associated with any signs or symptoms.

What Causes Barrett's Esophagus?

Barrett's Esophagus Symptoms

Barrett's Esophagus Pathology

Barrett's Esophagus Treatments

Barrett's Esophagus Genetics

Barrett's Esophagus with Dysplasia

Barrett's Esophagus Research

Non-Dysplastic Barrett's Esophagus

Barrett's Esophagus Preventing Progression

Latest Barrett's Esophagus News and Research

New hope for GI cancers: Review analyzes molecular targets and treatment advancements

Gastrointestinal (GI) cancers, encompassing esophageal, gastric, small bowel, and colorectal carcinomas, represent a significant global health burden due to their high incidence and mortality rates.

18 Jun 2024

AGA releases new evidence-based guideline on managing Barrett's esophagus and related neoplasia

The American Gastroenterological Association's (AGA) new evidence-based Clinical Practice Guideline on Endoscopic Eradication Therapy of Barrett's Esophagus and Related Neoplasia, published today in Gastroenterology, establishes updated guidance for Barrett's esophagus patients.

17 May 2024

Unraveling the mysteries of gastro-esophageal junction development

The transition from the esophagus to the stomach is a delicate region from a medical point of view, often associated with pathological disorders leading to cancer.

13 Apr 2024

EHR-embedded AI tool can identify patients at risk for esophageal and stomach cancer

In the United States and other western countries, a form of esophageal and stomach cancer has risen dramatically over the last five decades. Rates of esophageal adenocarcinoma, or EAC, and gastric cardia adenocarcinoma, or GCA, are both highly fatal.

22 Aug 2023

Study highlights need to improve screening and surveillance for Barrett's esophagus

A new study published in Gastroenterology aims to improve the effectiveness of screening and surveillance practices for early cancer detection in Barrett's esophagus (BE).

20 Jul 2023

Study traces the natural evolution of earliest stages of human cancers

Cancer cells-to-be accumulate a series of specific genetic changes in a predictable and sequential way years before they are identifiable as pre-malignancies, researchers at Stanford Medicine have found.

7 Jul 2023

Hackensack Meridian JFK University Medical Center launches new Gastroesophageal Reflux and Motility Program

Hackensack Meridian JFK University Medical Center today announced the opening of its new Gastroesophageal Reflux and Motility Program to provide expert diagnosis and treatment of gastroesophageal reflux disease, commonly known as GERD, and other, related motility disorders that affect the muscles in the gastrointestinal tract.

20 Mar 2023

Protein adduction and p53 tumor suppressor inhibition

Researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition.

27 Jan 2023

Researchers discover cell signaling pathway responsible for the development of esophageal cancers

Of the roughly 20,000 people in the U.S. diagnosed with esophageal cancer this year, just 4,000 are likely to still be alive in 2027.

28 Jul 2022

Scientists provide crucial insights into the roles of inflammation and oxidative stress in certain cancers

Rampant inflammation has long been linked to cancer but exactly how it pushes healthy cells to transform into malignant ones has remained a mystery.

7 Jun 2022

Analysis reveals increasing prevalence of esophageal cancer and Barrett’s esophagus in middle-aged adults

Adults aged 45 to 64 experienced a nearly doubled rate of esophageal cancer and a 50 percent increase in the precancerous condition Barrett's esophagus between 2012 and 2019, according to a database analysis of roughly five million patients to be presented at Digestive Disease Week 2022.

13 May 2022

Study shows how DNA changes in Barrett's esophagus cells may predict esophageal cancer

More and more mutations clutter up our DNA as we age. Mostly, these don't cause problems. But sometimes, a switch will flip, and a mutated cell turns cancerous. Can we see this shift in time to prevent or treat cancer before it starts?

28 Apr 2022

Novel diagnostic platform offers hope for early detection of cancer in patients with Barrett’s esophagus

On a mission to increase early detection of esophageal cancer, University of Colorado (CU) Cancer Center member Sachin Wani, MD, is leading a study to see if a novel diagnostic platform can help endoscopists better identify the disease in patients with a condition called Barrett's esophagus.

8 Feb 2022

Researchers develop a digital tool to better monitor Barrett's esophagus

A team including researchers from the Department of Energy's Oak Ridge National Laboratory has developed a digital tool to better monitor a condition known as Barrett's esophagus, which affects more than 3 million people in the United States.

12 Nov 2021

Acid pH enhances SARS-CoV-2 infection by up-regulating ACE2 receptor

A new study published in the journal Frontiers of Medicine indicated that Barrett's esophagus (BE) and gastroesophageal reflux disease (GERD) may represent novel comorbidities associated with SARS-CoV-2 disease. A previous study had estimated that in the United States, 5.6% of adults have BE, a disease where esophageal squamous mucosa gets damaged by GERD.

12 Sep 2021

Clinical discussions on diet-associated NAFLD and COVID-19 mortality risk among PPI users

The August issue of The American Journal of Gastroenterology includes clinical discussions of diet-associated NAFLD risk and increased risk of mortality from COVID-19 among PPI users.

16 Aug 2021

Study highlights the significance of screening for pre-cancerous Barrett’s esophagus

Abnormal cells that go on develop into oesophageal cancer – cancer that affects the tube connecting the mouth and stomach – start life as cells of the stomach, according to scientists at the University of Cambridge.

13 Aug 2021

Study discovers mechanism involved in the development of metaplasia in the esophagus

Metaplasia is defined as the replacement of a fully differentiated cell type by another. There are several classical examples of metaplasia, one of the most frequent is called Barrett's esophagus.

21 Apr 2021

New approach can help identify patients at risk for esophageal cancer

A combination of esophageal brushing and extensive genetic sequencing of the sample collected can detect chromosome alterations in people with Barrett's Esophagus, identifying patients at risk for progressing to esophageal cancer, according to a new study by researchers at the Johns Hopkins Kimmel Cancer Center and Case Western Reserve University.

29 Mar 2021

New technique may result in earlier and easier identification of patients with Barrett's esophagus

A new technique for sampling and testing cells from Barrett's esophagus (BE) patients could result in earlier and easier identification of patients whose disease has progressed toward cancer or whose disease is at high risk of progressing toward cancer, according to a collaborative study by investigators at Case Western Reserve University and Johns Hopkins Kimmel Cancer Center (JHKCC).

23 Mar 2021

Barrett's Esophagus

Overview

What Causes Barrett's Esophagus?

Barrett's Esophagus Symptoms

Barrett's Esophagus Pathology

Feature Articles

Barrett's Esophagus Treatments

Barrett's Esophagus Genetics

Barrett's Esophagus with Dysplasia

Barrett's Esophagus Research

Non-Dysplastic Barrett's Esophagus

Barrett's Esophagus Preventing Progression

Latest Barrett's Esophagus News and Research

New hope for GI cancers: Review analyzes molecular targets and treatment advancements

AGA releases new evidence-based guideline on managing Barrett's esophagus and related neoplasia

Unraveling the mysteries of gastro-esophageal junction development

EHR-embedded AI tool can identify patients at risk for esophageal and stomach cancer

Study highlights need to improve screening and surveillance for Barrett's esophagus

Study traces the natural evolution of earliest stages of human cancers

Hackensack Meridian JFK University Medical Center launches new Gastroesophageal Reflux and Motility Program

Protein adduction and p53 tumor suppressor inhibition

Researchers discover cell signaling pathway responsible for the development of esophageal cancers

Scientists provide crucial insights into the roles of inflammation and oxidative stress in certain cancers

Analysis reveals increasing prevalence of esophageal cancer and Barrett’s esophagus in middle-aged adults

Study shows how DNA changes in Barrett's esophagus cells may predict esophageal cancer

Novel diagnostic platform offers hope for early detection of cancer in patients with Barrett’s esophagus

Researchers develop a digital tool to better monitor Barrett's esophagus

Acid pH enhances SARS-CoV-2 infection by up-regulating ACE2 receptor

Clinical discussions on diet-associated NAFLD and COVID-19 mortality risk among PPI users

Study highlights the significance of screening for pre-cancerous Barrett’s esophagus

Study discovers mechanism involved in the development of metaplasia in the esophagus

New approach can help identify patients at risk for esophageal cancer

New technique may result in earlier and easier identification of patients with Barrett's esophagus

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Barrett's Esophagus

Overview

Feature Articles

Barrett's Esophagus Treatments

Barrett's Esophagus Genetics

Barrett's Esophagus with Dysplasia

Barrett's Esophagus Research

Non-Dysplastic Barrett's Esophagus

Barrett's Esophagus Preventing Progression

Latest Barrett's Esophagus News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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