CRISPR

In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

Understanding CRISPR Therapy

CRISPR technology revolutionizes gene therapy, offering potential treatments for genetic disorders and cancers through precise gene editing techniques.

CRISPR: Ethical and Safety Concerns

What is CRISPR/Cas9?

CPISPR Applications

CRISPR: The End for Zinc Fingers?

How Does CRISPR Compare to Other Gene-Editing Techniques?

Could CRISPR Repair CFTR in Cystic Fibrosis Patients?

Manipulating RNA sequences using CRISPR-Cas13

CRISPR-Cpf1

CRISPR Interference (CRISPRi) for Gene Suppression

Electroporation and the Production of Knockout Mice

CRISPR-Cas14: Discovery, Function, Advantages

See more featured articles »

Uses of CRISPR/Cas Biosensing Systems

Editing Sperm DNA using CRISPR

Unlocking the Potential: CRISPR-Cas9 Gene Editing in Liver Diseases

Latest CRISPR News and Research

New rabbit model provides insights into CF-related pancreatic endocrine pathology

Cystic fibrosis (CF) is a life-threatening genetic disease affecting multiple organ systems, with pancreatic dysfunction representing a critical and often overlooked complication.

17 Jan 2025

New approach shows promise in fighting multiple cancers

The tissue adjacent to a tumor behaves differently than areas farther away: The tumor's cancerous cells influence their surroundings, blocking the body's immune defenses and creating a sort of haven in which the tumor can grow. Treatments that target some of these pro-tumor actions are effective in a number of cancers, but only for some patients; in others, these treatments have little effect.

17 Jan 2025

Study unveils role of TLE6 in male sperm development

Infertility is a major global challenge associated with physiological and psychological impact. Genetic mutations that affect early embryonic development, oocyte (egg cell) maturation, and fertilization have recently been studied as causes of infertility.

16 Jan 2025

New gene-editing treatment extends lifespan in mice with prion disease

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition.

15 Jan 2025

The X factor: Decoding brain aging differences between men and women

Researchers unveil how biological sex influences brain aging, revealing genetic, hormonal, and molecular mechanisms behind cognitive resilience and decline.

9 Jan 2025

Functional characterization of variants improves cancer risk assessment and treatment

Findings from a multi-institutional, international study led by researchers from the Mayo Clinic Comprehensive Cancer Center have significantly advanced the understanding of genetic alterations in the BRCA2 gene, a key player in hereditary cancer risk.

9 Jan 2025

Investigating the impact of CircRNAs on cancer progression and drug resistance

The researcher has given an overview on the regulatory network of extracellular circRNAs in cancer and their impact on cancer drug resistance.

6 Jan 2025

Fruit flies steal bacterial defense to survive parasitic wasps

In the continual arms race between parasites and their hosts, innovation was thought to be the key to a successful attack or defense that one-ups the competition.

24 Dec 2024

SPLICER shows promise in Alzheimer's and other diseases

A new gene editing tool that helps cellular machinery skip parts of genes responsible for diseases has been applied to reduce the formation of amyloid-beta plaque precursors in a mouse model of Alzheimer's disease, researchers at the University of Illinois Urbana-Champaign report.

23 Dec 2024

Study unveils NAD's link to aging and disease development

UiB researchers are behind a new discovery that tells us how associated neurodegenerative diseases might develop.

23 Dec 2024

New approach in fighting leukemia with double-modified natural killer cells

Various forms of blood cancer exist – all of which are grouped together under the term leukemia. One common form of leukemia is acute myeloid leukemia (AML), characterized by a degradation of early blood cell precursors, i.e. stem cells and the precursor cells that develop from them.

18 Dec 2024

Nutrient metabolism regulates T cell exhaustion and therapy potential

Findings reveal that metabolic enzymes ACSS2 and ACLY regulate T cell exhaustion, linking nutrient metabolism to epigenetic changes in immunity.

17 Dec 2024

Researchers use innovative approach to uncover hidden bioactive compounds in bacteria

In contrast to humans, bacteria have the remarkable ability to exchange genetic material with each other.

14 Dec 2024

Study pinpoints how a network of different proteins controls rest and activation

Cells in the immune system don't always fight; they often rest and wait for threats, like viruses or bacteria.

11 Dec 2024

Extracellular vesicle DNA regulates immune responses and suppresses liver metastasis

The study highlights how EV-DNA packaging influences immune responses and its promise as a biomarker for assessing colorectal cancer metastasis risk.

6 Dec 2024

Study uncovers dangerous side effects of AZD7648 in gene editing

Genome editing with various CRISPR-Cas molecule complexes has progressed rapidly in recent years.

5 Dec 2024

Discovery of leptin-responsive neurons offers new hope for obesity treatment

Obesity affects a staggering 40 percent of adults and 20 percent of children in the United States. While some new popular therapies are helping to tackle the epidemic of obesity, there is still so much that researchers do not understand about the brain-body connection that regulates appetite.

5 Dec 2024