Chromosome News and Research

Latest Chromosome News and Research

Inhalable gene therapy may restore function of crucial enzyme to reverse deadly PAH

The deadly condition known as pulmonary arterial hypertension (PAH), which afflicts up to 150,000 Americans each year, may be reversible by using an inhalable gene therapy, report an international team of researchers led by investigators at the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai.

31 Jul 2013

Research shows exposure to BPA may play a role in unexplained infertility

As many as 20 percent of infertile couples in the United States have unexplained reasons for their infertility. Now, new research led by Catherine Racowsky, PhD, director of the Assisted Reproductive Technologies Laboratory at Brigham and Women's Hospital (BWH), shows that exposure to BPA (Bisphenol-A) could be a contributing factor as to why some infertile couples are having difficulty conceiving.

31 Jul 2013

Statins: A class of cholesterol-lowering drugs may help treat Rett Syndrome

Statins, a class of cholesterol-lowering drugs found in millions of medicine cabinets, may help treat Rett Syndrome, according to a study published today in Nature Genetics. The Rett Syndrome Research Trust (RSRT) funded this work with generous support from the Rett Syndrome Research Trust UK and Rett Syndrome Research & Treatment Foundation.

30 Jul 2013

Joints of children with chronic inflammatory arthritis contain premature aging of immune cells

The joints of children with the most common form of chronic inflammatory arthritis contain immune cells that resemble those of 90-year-olds, according to a new study led by researchers at Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine.

30 Jul 2013

Researchers to study knowledge and satisfaction of women who choose DNA prenatal screening test

A recently available DNA-based prenatal blood test used to screen pregnancies for Down syndrome and similar chromosome abnormalities in high-risk women is moving a step closer to use in the general pregnancy population.

From Natera 25 Jul 2013

Study results suggest reexamination of biological, medical importance of X chromosome

Painstaking new analysis of the genetic sequence of the X chromosome—long perceived as the "female" counterpart to the male-associated Y chromosome—reveals that large portions of the X have evolved to play a specialized role in sperm production.

24 Jul 2013

International Consortium receives grant to examine genetic reasons of schizophrenia in deletion syndrome patients

Today, the Royal College of Surgeons in Ireland (RCSI) will host a two day International Brain and Behaviour Consortium meeting on Chromosome 22q11.2 Deletion Syndrome (22q11.2DS).

24 Jul 2013

High arsenic levels in rice pose potential threat to human health: Study

High levels of arsenic in rice have been shown to be associated with elevated genetic damage in humans, a new study has found.

22 Jul 2013

CLAMP: A newly discovered protein that regulates genes

They say a good man is hard to find. Were it not for a newly discovered protein, the X chromosome of a male fruit fly could never be found by a gene-regulating complex that male flies need to develop and survive. And that case is just one example of what the new finding means. More generally, the research provides biologists with a model of how proteins that govern gene transcription find their targets on chromosomes, a process that's essential to healthy cell function and sometimes implicated in disease.

22 Jul 2013

NKX2-8 mutation in dogs may be a risk factor for human neural tube defects, say researchers

A gene related to neural tube defects in dogs has for the first time been identified by researchers at the University of California, Davis, and University of Iowa.

20 Jul 2013

C. difficile bacteriophage provides new weapon to battle against superbugs

IFR microbiologists are reinvigorating a way of battling C. difficile infections that they hope will help overcome the growing problem of antibiotic resistant superbugs in hospitals.

19 Jul 2013

Discovery provides evidence that genetic defect responsible for Down syndrome can be suppressed

Scientists at the University of Massachusetts Medical School are the first to establish that a naturally occurring X chromosome "off switch" can be rerouted to neutralize the extra chromosome responsible for trisomy 21, also known as Down syndrome, a genetic disorder characterized by cognitive impairment.

18 Jul 2013

Study shows CMEs can predict risk of cancer in type 2 diabetes patients

Certain chromosomal abnormalities of the preleukemic type appear to be over-represented in patients with type 2 diabetes (T2D) who are suffering from vascular complications. This finding may provide a partial explanation for the higher rates of cancer-related mortality observed among patients with this type of diabetes.

18 Jul 2013

Spectrum Pharmaceuticals enters into agreement to acquire Talon Therapeutics

Spectrum Pharmaceuticals, Inc., a biotechnology company with fully-integrated commercial and drug development operations with a primary focus in hematology and oncology, today announced that, through a wholly-owned subsidiary, the company entered into an agreement to acquire Talon Therapeutics, Inc., a biopharmaceutical company based in South San Francisco, California, and expects to complete the acquisition within one day.

17 Jul 2013

Proteins involved in immunity produce cancer-causing DNA mutations, study finds

A set of proteins involved in the body's natural defenses produces a large number of mutations in human DNA, according to a study led by researchers at the National Institutes of Health. The findings suggest that these naturally produced mutations are just as powerful as known cancer-causing agents in producing tumors.

15 Jul 2013

Advanced genetics technologies may help predict patient outcomes in people with ALL

New evidence suggests that using advanced genetics technologies to monitor for remaining cancer cells after treatment may soon become an effective tool to inform treatment decisions and ultimately predict patient outcomes for patients with a particularly aggressive form of acute lymphocytic leukemia (ALL).

10 Jul 2013

Pharmacyclics submits ibrutinib NDA to FDA for two B-cell malignancies

Pharmacyclics, Inc. today announced that it has submitted a New Drug Application to the U.S. Food and Drug Administration for the investigational oral Bruton's tyrosine kinase inhibitor, ibrutinib, for two relapsed/refractory B-cell malignancy indications: mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma.

10 Jul 2013

Study shows disrupted micronuclei may prove to be a valuable tool for detecting cancer

Scientists studying cancer development have known about micronuclei for some time. These erratic, small extra nuclei, which contain fragments or whole chromosomes that were not incorporated into daughter cells after cell division, are associated with specific forms of cancer and are predictive of poorer prognosis.

10 Jul 2013

Disrupted micronuclei might play more active role in carcinogenesis, new study finds

9 Jul 2013

Research shows mouse with greater life expectancy are shy and less active

Risky behavior can lead to premature death - in humans. Anna Lindholm and her doctoral student Yannick Auclair investigated whether this also applies to animals by studying the behavior of 82 house mice.

6 Jul 2013

Chromosome News and Research

Latest Chromosome News and Research

Inhalable gene therapy may restore function of crucial enzyme to reverse deadly PAH

Research shows exposure to BPA may play a role in unexplained infertility

Statins: A class of cholesterol-lowering drugs may help treat Rett Syndrome

Joints of children with chronic inflammatory arthritis contain premature aging of immune cells

Researchers to study knowledge and satisfaction of women who choose DNA prenatal screening test

Study results suggest reexamination of biological, medical importance of X chromosome

International Consortium receives grant to examine genetic reasons of schizophrenia in deletion syndrome patients

High arsenic levels in rice pose potential threat to human health: Study

CLAMP: A newly discovered protein that regulates genes

NKX2-8 mutation in dogs may be a risk factor for human neural tube defects, say researchers

C. difficile bacteriophage provides new weapon to battle against superbugs

Discovery provides evidence that genetic defect responsible for Down syndrome can be suppressed

Study shows CMEs can predict risk of cancer in type 2 diabetes patients

Spectrum Pharmaceuticals enters into agreement to acquire Talon Therapeutics

Proteins involved in immunity produce cancer-causing DNA mutations, study finds

Advanced genetics technologies may help predict patient outcomes in people with ALL

Pharmacyclics submits ibrutinib NDA to FDA for two B-cell malignancies

Study shows disrupted micronuclei may prove to be a valuable tool for detecting cancer

Disrupted micronuclei might play more active role in carcinogenesis, new study finds

Research shows mouse with greater life expectancy are shy and less active

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Chromosome News and Research

Latest Chromosome News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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