Chromosome News and Research

Latest Chromosome News and Research

Sex chromosome genes influence aggression

It has been well documented that, across human cultures and in most mammals, males are usually more aggressive and less nurturing than females.

9 Mar 2006

Cell-death mechanism linked to developmental and degenerative brain disorders

Conclusive evidence that neurodevelopmental disorders such as mental retardation and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and ataxias can be caused, at least in part, by specific gene defects that interfere with the electrical impulses of rapid-firing brain nerve cells called bursting neurons.

1 Mar 2006

SRY protein explains why men more likely to develop Parkinson's

Scientists at Prince Henry's Institute, Melbourne, and the University of California, Los Angeles, have discovered that SRY, the male protein that forms the testes is also produced in the brain region affected in Parkinson's disease.

24 Feb 2006

Surname prediction from DNA alone may be feasible

By comparing the DNA of 150 pairs of men who share British surnames, researchers have shown that about a quarter of pairs are linked genetically.

23 Feb 2006

SRY gene directly controls neuronal function in the brain

Shaped by much previous research, the prevailing view regarding sex-specific differences in the brain is that they are caused by circulating sex hormones, which are generated outside the brain and influence certain aspects of brain development, as well as brain function in adults.

23 Feb 2006

X chromosome dosage compensation occurs in germ cells

X chromosome dosage compensation does occur in germ cells. A study published today in the open access journal Journal of Biology reveals that expression of the genes on the X chromosome is doubled in Drosophila germ cells to compensate for the missing second X chromosome.

17 Feb 2006

GeneDesign speeds design of artificial pieces of DNA

Johns Hopkins researchers have announced the development of a Web-based, automated computer program that they say greatly simplifies the time-consuming and error-prone process of manually designing artificial pieces of DNA.

17 Feb 2006

Inactivating Rad9 protien could make cancer cells easier to kill with ionizing radiation

The researchers found that Rad9, previously considered a "watchman" that checks for DNA damage, is actually a "repairman" that fixes dangerous breaks in the DNA double helix. They found Rad9 is especially active in telomeres, the protective ends of chromosomes.

17 Feb 2006

New insight into pathogenic mechanisms underlying basal-like breast cancers

Basal-like breast cancers (BLC) are highly aggressive tumors with a relatively poor prognosis that account for approximately 15% of sporadic human breast cancer.

16 Feb 2006

X chromosome dosage compensation proven in germ cells

16 Feb 2006

Aging cells help make old bodies

Brown University biologists have uncovered intriguing evidence to support the theory that old cells help make old bodies. In a study of baboons, scientists showed that as these animals age, the number of aging cells in their skin significantly increases.

12 Feb 2006

DNA end caps may lead to cancer treatments

The two ends of human DNA have different structures that are treated differently as a cell divides, UT Southwestern Medical Center researchers have found in a study that could help lead to cancer therapies.

7 Feb 2006

Scientists have determined the detailed structure of an essential piece of the telomerase enzyme

Scientists have determined the detailed structure of an essential piece of the telomerase enzyme, an important contributor to the vast majority of human cancers. Understanding the physical shape of the protein has led to a better understanding of how it acts to immortalize cells - and should help scientists design broadly effective cancer drugs.

5 Feb 2006

Chinese medicine shows promise as treatment for sperm genetic abnormalities

Bioscientists from the University of Kent have called for clinical trials to further investigate how traditional Chinese medicine (TCM) may have a positive effect on sperm genetic abnormalities, and thereby influence the success rate of male infertility treatment.

2 Feb 2006

Counting cells that ensure gene balance

Two are one too many - this is the motto used by cells of a female organism: These contain two X chromosomes, one of which always becomes inactivated.

2 Feb 2006

Identity Swap: Finding the variants that human history has favoured

Sequence differences in less than 0.2% of the 3-billion-base human genome play a vital role in a bewildering variety of human disease. Researchers from the Wellcome Trust Sanger Institute and the Cambridge University’s Cambridge Institute for Medical Research, together with international colleagues report in PLoS Genetics their detailed maps of differences implicated in disease as well as genes that are unchanged in recent human history.

26 Jan 2006

Treatment of down syndrome in mice restores nerve growth in cerebellum

Researchers at Johns Hopkins restored the normal growth of specific nerve cells in the cerebellum of mouse models of Down syndrome (DS) that were stunted by this genetic condition. The cerebellum is the rear, lower part of the brain that controls signals from the muscles to coordinate balance and motor learning.

25 Jan 2006

New method to find new metabolites

Ever since penicillin, a byproduct of a fungal mold, was discovered in 1929, scientists have scrutinized fungi for other breakthrough drugs. As reported Jan. 20 in the Journal of Chemistry and Biology, a team led by a University of Wisconsin-Madison researcher has developed a new method that may speed the ongoing quest for medically useful compounds in fungi.

23 Jan 2006

Protein amplifies DNA injury signals - cues genetic repair mechanism to prevent tumors

A Mayo Clinic-led research collaboration has discovered that the protein MDC1 amplifies weak DNA injury signals so genetic repair can begin.

23 Jan 2006

TCF21 gene shown to be a tumor suppressor

Researchers have identified a new and unusual tumor suppressor gene that may be important in cancers of the lung and head and neck. The study shows that restoring the inactivated gene can slow the growth of tumor cells.

18 Jan 2006