Chromosome News and Research

Latest Chromosome News and Research

Largest "gene deserts" yet discovered in the human genome sequence

A detailed analysis of chromosomes 2 and 4 has detected the largest "gene deserts" known in the human genome and uncovered more evidence that human chromosome 2 arose from the fusion of two ancestral ape chromosomes, researchers supported by the National Human Genome Research Institute (NHGRI).

6 Apr 2005

Method of gene therapy accurately corrects mutations in disease-causing genes

Harnessing the strength of a natural process that repairs damage to the human genome, a researcher from UT Southwestern Medical Center has helped establish a method of gene therapy that can accurately and permanently correct mutations in disease-causing genes.

5 Apr 2005

DNA repair kit announced by scientists

A study by scientists at Sangamo BioSciences, Inc. has demonstrated the use of the Company's zinc finger DNA-binding protein (ZFP) technology to achieve highly efficient, permanent correction of a disease-causing gene in primary human cells.

5 Apr 2005

Method of gene therapy that can accurately and permanently correct mutations in disease-causing genes

4 Apr 2005

Mutations in the HFE gene directly associated with chronic joint disease

Mutations in the HFE gene, which is involved in iron regulation, seem to be directly associated with chronic joint disease (or haemophilic arthropathy) among haemophilic patients, claim a team of Portuguese scientists in the April issue of the journal Blood.

4 Apr 2005

Scientists identify novel regulator of telomere homeostasis

Each of our 46 chromosomes is capped by a telomere – a long stretch of repeated DNA (TTAGG). Telomeres play a key protective function in our cells, and now Dr. In Kwon Chung and colleagues at Yonsei University (Seoul, Korea) and the University of Central Florida reveal a novel mechanism to modulate telomere length.

3 Apr 2005

Location on chromosome 2 that may contain one or more genes that contribute to dyslexia

Researchers trying to tease out the genetic basis of dyslexia have discovered a location on chromosome 2 that may contain one or more genes that contribute to the reading disorder and make it difficult for people to rapidly pronounce pseudowords.

3 Apr 2005

Dozens of new genes identified in X chromosome

By intensely and systematically comparing the human X chromosome to genetic information from chimpanzees, rats and mice, a team of scientists from the United States and India has uncovered dozens of new genes, many of which are located in regions of the chromosome already tied to disease.

3 Apr 2005

SERPINE2 identified as novel candidate gene for COPD susceptibility

Using a combination of genetic linkage, microarray gene expression and genetic association studies, a group of Brigham and Women’s Hospital/ Harvard Medical School researchers have identified a serine protease inhibitor clade E, member 2, or SERPINE2, “as a novel candidate susceptibility gene for COPD,” according to Sorachai Srisuma

3 Apr 2005

Urine actually helps a particular yeast stick to cells along the urinary tract

The finding might offer a new way to prevent or treat certain yeast and fungal infections, and the researchers' work also provides an unexpected new role for some proteins already known to help hungry yeast live longer.

30 Mar 2005

Protein Mnd2 protects chromosome bonds

The protein Mnd2 inhibits premature separation of chromosomes during the formation of gametes. The now published discovery of this regulatory function may help to understand the origin of some common congenital chromosome defects.

30 Mar 2005

Gene named ATBF1 may contribute to the development of prostate cancer

A gene named ATBF1 may contribute to the development of prostate cancer through acquired mutations and/or loss of expression, according to research at Emory University School of Medicine and its Winship Cancer Institute.

23 Mar 2005

X-Chromosome has the big story!!

The human genome is said by some to be the "book of life," and the X-chromosome a large part of the the plot. A team of genome researchers have described the nature of this mysterious "chapter" in the DNA story.

17 Mar 2005

Neuronal death and processing of Tau protein in Alzheimer’s Disease (AD)

In a research report recently published in the Journal of Alzheimer's Disease, published by IOS Press, a research group from the International School for Advanced Studies (ISAS\SISSA) in Trieste (Luisa Fasulo, Gabriele Ugolini e Antonino Cattaneo) showed that a processed form of tau protein induces neuronal death by apoptosis (programmed cell death) when expressed in cultured rat hippocampal neurons.

15 Mar 2005

Gene identified that confers susceptibility to age-related macular degeneration

By combining the tools of high-throughput biology and statistical genetics, scientists at Rockefeller University, Yale University School of Public Health and the National Eye Institute have identified a gene that confers susceptibility to age-related macular degeneration (AMD), the most common cause of vision loss in the United Sates for those over 60.

14 Mar 2005

DNA weak links may provide clues to cancer biology

The chromosomes of mammals, including humans, contain regions that are particularly prone to breaking under conditions of stress and in cancer. Now, new research by geneticists at Duke University Medical Center finds that yeast cells also contain such weak links in DNA and begins to reveal the molecular characteristics of these links that might help to explain them.

13 Mar 2005

Gene for AMD has now been identified by researchers

Age-related macular degeneration (AMD) is a debilitating eye disease affecting about 15 million people in the United States.

13 Mar 2005

Mouse gene shows new mechanism behind cardiac infarction in man

A gene that, in different variants, increases or decreases the level of atherosclerosis has been identified in mice. The corresponding human gene has been shown to play a role in the development of myocardial infarction.

9 Mar 2005

Telomerase finding has major implications for cancer

UCLA biochemists have determined the three-dimensional structure of a major domain of telomerase, the enzyme that helps maintain telomeres - small pieces of DNA on the ends of chromosomes that act as protective caps - allowing DNA ends to be copied completely when cells are replicated.

9 Mar 2005

Discovery gives clinicians new targets for making existing therapies more effective and developing drugs to inhibit the growth of cancers

A team of researchers at the University of Alberta in Edmonton and the Samuel Lunenfeld Research Institute in Toronto have discovered how a key enzyme involved in repairing DNA is put together and how it works--a development that opens up new therapies for making cancer cells more vulnerable to attack.

3 Mar 2005