Chromosome News and Research

Latest Chromosome News and Research

Whitehead researchers create 3D map to predict how genes are regulated in normal cells

Whitehead Institute researchers have created a map of the DNA loops that comprise the three dimensional (3D) structure of the human genome and regulate gene expression in human embryonic stem (ES) cells and adult cells. The location of genes and regulatory elements within this chromosomal framework could help scientists better navigate their genomic research, establishing relationships between mutations and disease development.

13 Dec 2015

TBK1 protein plays vital role in the process of cell division

Moffitt Cancer Center researchers have found that a protein called TBK1 plays an important role in the process of cell division, especially at a stage called mitosis.

11 Dec 2015

Sex differences in the brain may provide clues to why certain forms of autism more common in males

Many early-onset neurodevelopmental disorders, including autism spectrum disorders, are more common in males than females. The origin of this gender bias is not understood, partially due to a major gap in research on sex differences regarding how the brain typically develops.

11 Dec 2015

Marqibo now available to leukemia patients through myTomorrows' Internet-based platform

myTomorrows (Amsterdam, the Netherlands), announced today that it has started a collaboration with Spectrum Pharmaceuticals, Inc. (Henderson, USA) to provide access to its liposome-encapsulated vincristine for treatment of Philadelphia chromosome negative acute lymphoblastic leukemia.

10 Dec 2015

Textbook view of the human cell cycle needs to be revised, shows new Danish research

Ground-breaking new Danish research has shown that the current scientific description of the human cell cycle needs to be revised. These findings could also lead to the development of new therapeutic approaches to target an Achilles' heel in different types of cancers.

9 Dec 2015

Yale study explores link between body fat, weight loss and telomere length in breast cancer survivors

It is well documented that a healthy diet and exercise are key in cancer prevention and management, but the exact mechanism hasn't been clear. Now, Yale Cancer Center researchers have found an explanation in the tiny protective ends of chromosomes called telomeres. The findings will be presented Dec. 11 at the 2015 San Antonio Breast Cancer Symposium.

9 Dec 2015

Researchers find new significant link between NPM protein and development of AML

A team of researchers from the National University of Singapore has found a new significant correlation between the protein nucleophosmin (NPM) and the development of an aggressive form of blood cancer called acute myeloid leukemia (AML).

8 Dec 2015

Amgen’s Phase 2 data supports safety, efficacy of BLINCYTO in ALL patients with minimal residual disease

Amgen today announced that new data from three Phase 2 trials support the efficacy and safety of BLINCYTO (blinatumomab) in adults with acute lymphoblastic leukemia (ALL).

8 Dec 2015

Faulty gene function responsible for reducing survival times of leukaemia patients

Researchers have identified a genetic fault in some leukaemia patients that could be responsible for halving survival times after diagnosis compared to patients without the fault – an average reduction from 16 years to seven years. T

8 Dec 2015

New approaches to treating leukemia, lymphoma and myeloma

New, highly targeted treatment approaches for leukemia, lymphoma, and myeloma to be presented today at the 57th American Society of Hematology Annual Meeting and Exposition represent a tremendous expansion of oral and intravenous therapy options for patients with blood cancers.

7 Dec 2015

Gene therapy shows promise in children with Wiskott-Aldrich syndrome

Researchers reported promising preliminary outcomes for the first four children enrolled in a U.S. gene therapy trial for Wiskott-Aldrich syndrome (WAS), a life-threatening genetic blood and immune disorder, at the 57th annual meeting of the American Society of Hematology (abstract #260).

7 Dec 2015

Neoadjuvant chemotherapy can stimulate evolution of breast cancer tumor

Russian scientists have found that neoadjuvant chemotherapy in patients with breast cancer can stimulate evolution of the tumor. The results of the research conducted by Nicholay Litvyakov, D.Sc. at Cancer Research Institute, Head of the Tumor Virology Laboratory, and TSU researcher Marina Ibragimova, were published in "Siberian Journal of Oncology."

1 Dec 2015

Second-line bosutinib offers ‘durable’ response for chronic phase CML patients

Four-year results for an ongoing study of second-line bosutinib indicate that the tyrosine kinase inhibitor offers long-term efficacy with manageable side effects for patients with chronic phase chronic myeloid leukaemia.

27 Nov 2015

Specific environmental influences can neutralize effect of genetic variant that increases childhood asthma risk

The effect of a widespread genetic variant that increases the risk for childhood asthma can be neutralized. A new study shows that young infants are particularly responsive to the positive influence of exposure to farm dust.

27 Nov 2015

Researchers reveal causal association between aneuploidy and cancer

Publication in Nature Cell Biology: researchers at the Université libre de Bruxelles - ULB Cancer Research Center, U-CRC - show the causal link between aneuploidy and cancer.

24 Nov 2015

Rutgers research reveals mechanism to prevent benign kidney tumor from becoming cancerous

Research from investigators at Rutgers Cancer Institute of New Jersey examining the inner workings of a rare non-cancerous (benign) kidney tumor has revealed a mechanism to prevent this type of tumor from becoming cancerous (malignant).

22 Nov 2015

FEC recognizes Rachel S. Weinerman for receiving 2015 Scientific Program Prize Paper Award

The Foundation for Embryonic Competence is pleased to recognize Dr. Rachel S. Weinerman, a clinical assistant professor, reproductive endocrinology and infertility at University Hospitals Case Medical in Cleveland, for receiving the 2015 Scientific Program Prize Paper Award at the 71st Annual American Society for Reproductive Medicine conference in Baltimore, Maryland on October 21, 2015.

12 Nov 2015

New method may extend use of noninvasive prenatal testing to detect chromosomal abnormalities

Researchers at the University of California, San Diego School of Medicine developed a method to expand the types of chromosomal abnormalities that noninvasive prenatal testing (NIPT) can detect. The study, published November 9 by Proceedings of the National Academy of Sciences, uses a semiconductor sequencing platform to identify small chromosomal deletions or duplications, such as occur in Cri du Chat Syndrome and DiGeorge Syndrome, with a simple blood test from the expectant mother.

10 Nov 2015

Two studies explore potential new blood tests for Alzheimer's disease

There is increasing evidence that the brain changes of Alzheimer's disease begin decades before memory and thinking problems occur, prompting the need for better methods of early detection for this progressive, fatal brain disease. Consequently, there is a growing school of thought that the most effective future Alzheimer's drug therapies will be administered to those who are at high risk of the disease before cognitive symptoms appear.

10 Nov 2015

Urinary biomarkers for bladder cancer diagnosis fall short of mark

Authors of a meta-analysis question the accuracy of urinary biomarkers for diagnosing the initial incidence or recurrence of bladder cancer.

4 Nov 2015

Chromosome News and Research

Latest Chromosome News and Research

Whitehead researchers create 3D map to predict how genes are regulated in normal cells

TBK1 protein plays vital role in the process of cell division

Sex differences in the brain may provide clues to why certain forms of autism more common in males

Marqibo now available to leukemia patients through myTomorrows' Internet-based platform

Textbook view of the human cell cycle needs to be revised, shows new Danish research

Yale study explores link between body fat, weight loss and telomere length in breast cancer survivors

Researchers find new significant link between NPM protein and development of AML

Amgen’s Phase 2 data supports safety, efficacy of BLINCYTO in ALL patients with minimal residual disease

Faulty gene function responsible for reducing survival times of leukaemia patients

New approaches to treating leukemia, lymphoma and myeloma

Gene therapy shows promise in children with Wiskott-Aldrich syndrome

Neoadjuvant chemotherapy can stimulate evolution of breast cancer tumor

Second-line bosutinib offers ‘durable’ response for chronic phase CML patients

Specific environmental influences can neutralize effect of genetic variant that increases childhood asthma risk

Researchers reveal causal association between aneuploidy and cancer

Rutgers research reveals mechanism to prevent benign kidney tumor from becoming cancerous

FEC recognizes Rachel S. Weinerman for receiving 2015 Scientific Program Prize Paper Award

New method may extend use of noninvasive prenatal testing to detect chromosomal abnormalities

Two studies explore potential new blood tests for Alzheimer's disease

Urinary biomarkers for bladder cancer diagnosis fall short of mark

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Chromosome News and Research

Latest Chromosome News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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