Crohn's Disease

Crohn’s disease is a chronic inflammatory disease of the bowel affecting at least 115,000 people in the UK. The condition usually develops in teenagers and young adults, but can be diagnosed at any age and is equally common in men and women.

What is Crohn's Disease?

Crohn’s disease is a disease that leads to severe inflammation of the lining of the digestive system.

Crohn's Disease Symptoms

Crohn's Disease Cause

Crohn's Disease Diagnosis

Crohn's Disease Treatment

Crohn's Disease Complications

History of Crohn's Disease

Intestinal Mycoplasma and Crohn's Disease

Latest Crohn's Disease News and Research

Sulfide-producing bacteria may explain lingering symptoms in Crohn's disease

A study from University of Michigan researchers may provide an explanation for why some patients with Crohn's disease continue to experience symptoms, even in the absence of inflammation.

19 Dec 2024

NYU Langone IBD Center celebrates two years of transforming lives

A complex, chronic, and debilitating condition, inflammatory bowel disease (IBD) affects roughly 3 million Americans, including those with Crohn's disease and ulcerative colitis.

16 Dec 2024

Filgotinib offers new promise for managing Crohn’s disease

Filgotinib, a JAK1 preferential inhibitor, shows promise as an effective and well-tolerated maintenance therapy for Crohn's disease, achieving clinical and endoscopic remission in phase 3 trials. The findings highlight its potential as a novel therapeutic option for difficult-to-treat patients.

8 Dec 2024

Specific protein patterns can predict IBD up to 16 years before diagnosis

Scientists at örebro University have identified specific protein patterns in blood that can predict inflammatory bowel disease (IBD) up to 16 years before diagnosis.

26 Nov 2024

More than 100,000 young people in the US live with inflammatory bowel disease

The prevalence of inflammatory bowel disease in U.S. children under 20 is increasing, with over 100,000 affected, revealing critical public health concerns.

22 Nov 2024

New molecule promotes gut healing and suppresses tumor growth in colorectal cancer

Researchers at Karolinska Institutet have found a molecule that can both help the intestines to heal after damage and suppress tumor growth in colorectal cancer.

21 Nov 2024

New atlas maps 1.6 million human gut cells in unprecedented detail

The most comprehensive cell map of the human gut to date has been created by combining spatial and single-cell data from 1.6 million cells.

21 Nov 2024

Electrical stimulation of vagus nerve could combat inflammatory bowel disease

Researchers at Duke University School of Medicine have found that tapping into the nervous system could help reduce the gut inflammation that drives inflammatory bowel disease (IBD).

20 Nov 2024

Landmark study highlights growing pediatric IBD rates across the U.S.

A groundbreaking study published today in Gastroenterology provides the most comprehensive assessment to date of pediatric inflammatory bowel disease (IBD) prevalence in the United States.

20 Nov 2024

Microbial density in our gut shapes how diseases are linked to gut health

The study in Cell highlights microbial load's role in gut microbiome variation, suggesting it as a confounder in disease research and a key health determinant.

15 Nov 2024

Link between COVID-19 and long-term risk of autoimmune and autoinflammatory connective tissue disorders

COVID-19 survivors may develop autoimmune conditions long-term, with risks varying by severity and vaccination status, necessitating continued health vigilance.

8 Nov 2024

New biomarker could predict response to IBD treatment

Not everyone responds equally well to treatments for inflammatory bowel disease (IBD). What will work for individual patients involves trial and error during the treatment process.

7 Nov 2024

Binghamton University joins groundbreaking $42.8 million inflammatory disease treatment project

Binghamton University will play a key role in a federal grant of up to $42.8 million to develop an implantable device that acts as a living pharmacy to treat inflammatory diseases.

5 Nov 2024

Link between inflammatory bowel disease and spondyloarthritis revealed

There is a strong connection between inflammatory bowel disease (IBD) and spondyloarthritis - a condition that causes pain and stiffness in the joints.

28 Oct 2024

Helene and CVS land double whammy for 25,000 patients who survive on IV nutrition

The CVS representative popped into Lisa Trumble's third-floor Berkshire Medical Center hospital room in Pittsfield, Massachusetts, to announce that everything was arranged for Trumble to return home, where she relies on IV nutrition because of severe intestinal problems that leave her unable to eat.

18 Oct 2024

Early signs of inflammatory bowel disease detected in newborns

Across the Western world, the prevalence of these chronic and serious conditions, which have no cure, is rising. In Denmark alone, 50,000 people suffer from either Crohn's disease or ulcerative colitis, which represents a doubling in cases over the past 20 years.

12 Oct 2024

Scientists uncover two Crohn’s disease subtypes using lab-grown intestines, offering hope for personalized therapies

Researchers used stem-cell derived organoids from Crohn's disease patients to identify two molecular subtypes, paving the way for personalized treatments targeting specific disease characteristics.

2 Oct 2024

Patient-derived gut organoids reveal new insights into Crohn's disease subtypes

Crohn's disease -; an autoimmune disorder -; is characterized by chronic inflammation of the digestive tract, resulting in a slew of debilitating gastrointestinal symptoms that vary from patient to patient.

26 Sep 2024

Targeted drug therapy shows promise for ulcerative colitis remission

An international placebo-controlled study led by Cedars-Sinai suggests that a targeted drug therapy that was developed by researchers at Cedars-Sinai is safe and effective at helping people with moderate to severe ulcerative colitis reach clinical remission.

26 Sep 2024

Researchers gain new understanding of how immune cells respond to heat during fever

The study reveals that moderate fever enhances CD4 T cell activity while reducing regulatory T cell suppression, highlighting temperature's immune effects.

25 Sep 2024