Depression

Depression is a serious medical illness that involves the brain. It's more than just a feeling of being "down in the dumps" or "blue" for a few days. If you are one of the more than 20 million people in the United States who have depression, the feelings do not go away. They persist and interfere with your everyday life.

Clinical Depression: Diagnosis, Causes & Treatment

Depression is a clinical condition that, contrary to popular opinion, cannot simply be overcome with time and it needs to be treated.

Intrusive Thoughts and Depression

5 Facts You May Not Know About Depression

Supporting Children with Mental Health Disorders

Causes of Depression

How is Depression in Children Diagnosed?

How Can I Tell if My Child is Depressed?

Situational Depression: Symptoms, Causes, Treatments

Depression in children

The Science Behind the Winter Blues: Understanding Seasonal Affective Disorder

Depression Diagnosis

Prisoner Depression and Low Mood

See more featured articles »

Link Between Chronic Illness and Depression

Can Depression and Anxiety Occur Together?

How Does Your Diet Affect Depression?

Treatment Options for Children with Depression

Depression and Sleep Length

Symptoms of Depression

Ghrelin and Depression

Contributing Factors to Post-Adoption Depression

Genes and Depression

Food Insecurity and Depression

Treatment of Depression

Antidepressants and Weight Changes

Latest Depression News and Research

Genetic overlap links psychiatric disorders with many physical ailments

For centuries, mental illness and physical disease have been viewed as two distinct categories, each with its own field of study, its own doctors, and its own menu of treatments.

8 Apr 2026

Study identifies a common brain activity pattern across psychedelics

Scientists have demonstrated, for the first time, that several psychedelic drugs – including psilocybin, LSD, mescaline, DMT and ayahuasca – produce a common pattern of brain activity despite their distinct chemistries.

8 Apr 2026

Duloxetine fails to prevent nerve damage caused by chemotherapy

A randomized trial conducted by the Alliance for Clinical Trials in Oncology with support from the National Cancer Institute has found that duloxetine, a medication commonly used to treat chronic pain and psychiatric conditions, does not prevent nerve damage caused by chemotherapy in patients with colorectal cancer.

8 Apr 2026

Higher optimism linked to lower dementia risk

Higher optimism is associated with a lower risk of developing dementia, according to a new study in the Journal of the American Geriatrics Society.

8 Apr 2026

New guidelines and follow-up standards improve pulmonary embolism outcomes

Pulmonary embolism, or PE, is a serious and sometimes life-threatening condition that occurs when a blood clot travels to the lungs and blocks blood flow.

8 Apr 2026

Hearing loss and sex shape dual-task outcomes in older adults with mild cognitive impairment

Cognitive and physical training can help older adults with mild cognitive impairment (MCI) maintain or improve their ability to move and think simultaneously, but hearing ability and sex influence outcomes, according to a new Concordia-led study.

7 Apr 2026

What happens in the brain on psychedelics? Scientists identify a common circuit pattern

Researchers combined 11 international resting-state fMRI datasets to map how psychedelic drugs reshape brain connectivity across cortical and subcortical circuits. The mega-analysis found a shared signature of stronger coupling between transmodal association networks and unimodal or sensorimotor systems, alongside selective and variable reductions in within-network connectivity.

7 Apr 2026

Navigated TMS significantly boosts combat PTSD recovery rates

An advanced version of a procedure using magnetic fields to stimulate brain nerve cells in treating depression was significantly effective for 85% of active military and veterans suffering from combat post-traumatic stress disorder enrolled in a recent study, when added to psychotherapy.

7 Apr 2026

New guidelines aim to improve concussion care for first responders

Management of sports-related concussions has come a long way in the past 25 years: Once considered a minor problem involving minimal time out of the game, a severe knock to the head is now assessed as a potential traumatic brain injury and, if confirmed, requires a structured recovery and an average wait of 13 days before play resumes.

6 Apr 2026

Estonian study reveals varied stress responses during first pandemic year

Karel Kulbin, a well-being researcher at Tallinn University, focuses in his doctoral thesis on how perceived stress levels and depressive symptoms among Estonian residents changed during the first year of the pandemic and what role active leisure activities played in this.

6 Apr 2026

Study shows masculine depression is not just a male mental health pattern

Researchers found that depressed inpatients with high masculine depression scores had a substantially greater acute mental health burden across multiple symptom domains, even after accounting for overall depression severity. The paper also found this pattern was not specific to men, supporting “masculine depression” as a descriptive, sex-independent behavioral profile rather than a male-only condition.

6 Apr 2026

Irregular bedtimes double heart risk for those getting below 8 hours

Irregular sleep timing significantly impacts heart health, with inconsistent bedtimes linked to a higher risk of major cardiovascular events over a decade.

6 Apr 2026

Smartphone app HabitWorks improves anxiety and depression symptoms

In an effort to increase access to evidence-based interventions to help manage anxiety and depression, Mass General Brigham investigators have developed and tested a novel digital intervention called HabitWorks.

2 Apr 2026

Sleep apnea raises risk of cardiovascular events and death

New research to be presented at this year's European Congress on Obesity (ECO 2026, Istanbul, Turkey, 12-15 May) shows that those living with obstructive sleep apnea (OSA) have a 71% higher risk of cardiovascular events (CVEs) or death from any cause (all-cause mortality) compared with those not living with OSA.

2 Apr 2026

Finnish study reveals how parental immigration status impacts child mental health

A new nationwide Finnish register study shows that children with two immigrant parents are significantly less likely to receive mental health services for anxiety and depression than children of Finnish parents.

2 Apr 2026

Trial tests fast-acting brain stimulation for postpartum depression treatment

The Icahn School of Medicine at Mount Sinai today announced the enrollment of its first patient in a U.S. Department of Defense-funded pivotal clinical trial to evaluate whether a fast-acting, drug-free brain stimulation therapy can safely and quickly relieve symptoms of postpartum depression.

1 Apr 2026

Vitamin D levels in midlife tied to lower dementia risk marker

Having higher levels of vitamin D in the blood in middle age is associated with lower levels of tau protein in the brain, which is a sign of dementia, years later, according to a study published April 1, 2026, in Neurology Open Access, an official journal of the American Academy of Neurology.

1 Apr 2026

Mono infection associated with threefold higher multiple sclerosis risk

Having the disease infectious mononucleosis, often called mono, caused by the Epstein-Barr virus is associated with an increased risk of developing multiple sclerosis (MS), according to a study published on April 1, 2026, in Neurology® Open Access, an official journal of the American Academy of Neurology.

1 Apr 2026

Highly potent opioid shows potential as therapy for pain and opioid use disorder

Researchers at the National Institutes of Health (NIH) have identified a novel, highly potent opioid that shows potential as a therapy for both pain and opioid use disorder.

1 Apr 2026

Antibiotic use before and during pregnancy linked to psychological distress

Perinatal depression, which occurs during pregnancy or in the period after childbirth, is one of the most common mental health conditions experienced by women.

1 Apr 2026