Depression

Depression is a serious medical illness that involves the brain. It's more than just a feeling of being "down in the dumps" or "blue" for a few days. If you are one of the more than 20 million people in the United States who have depression, the feelings do not go away. They persist and interfere with your everyday life.

Clinical Depression: Diagnosis, Causes & Treatment

Depression is a clinical condition that, contrary to popular opinion, cannot simply be overcome with time and it needs to be treated.

Can Depression and Anxiety Occur Together?

Depression in children

Antidepressants and Weight Changes

Causes of Depression

Depression Diagnosis

Treatment Options for Children with Depression

Prisoner Depression and Low Mood

Situational Depression: Symptoms, Causes, Treatments

Intrusive Thoughts and Depression

The Science Behind the Winter Blues: Understanding Seasonal Affective Disorder

Genes and Depression

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Contributing Factors to Post-Adoption Depression

5 Facts You May Not Know About Depression

Ghrelin and Depression

How Does Your Diet Affect Depression?

Food Insecurity and Depression

Supporting Children with Mental Health Disorders

How Can I Tell if My Child is Depressed?

Treatment of Depression

Link Between Chronic Illness and Depression

Depression and Sleep Length

Symptoms of Depression

How is Depression in Children Diagnosed?

Latest Depression News and Research

People with traumatic spinal cord injuries at higher risk of developing chronic health problems

A new study by investigators from Mass General Brigham shows that patients with traumatic spinal cord injuries (TSCI) are at a higher risk of developing a myriad of chronic health problems, regardless of age, location of the injury and prior health status.

4 Nov 2025

New review illuminates the intricate connections between gut microbiota and sleep regulation

A comprehensive review published today in Brain Medicine illuminates the intricate connections between gut microbiota and sleep regulation, establishing the microbiota-gut-brain axis as a critical pathway in understanding and potentially treating sleep disorders.

4 Nov 2025

Stress hormones may silence crucial neuronal genes through specific RNA molecules

What if the brain's response to stress could be read not in fleeting neurotransmitter bursts, but in the quieting of genes deep inside chromatin? Researchers at the University of Alabama at Birmingham have now shown that stress hormones may silence crucial neuronal genes through an unexpected class of RNA molecules that operate not by encoding proteins, but by reshaping the genome's architecture.

4 Nov 2025

Gut bacteria in toddlers may influence anxiety and depression years later

This study links childhood gut microbiome to brain connectivity, highlighting its role in internalizing symptoms like anxiety and depression later in life.

4 Nov 2025

Indoor hydroponic gardening boosts wellbeing for cancer patients

Indoor hydroponic gardening - a method of growing plants using nutrient-rich water instead of soil - could help cancer patients develop better mental health, eat a healthier diet and enjoy a better overall quality of life.

4 Nov 2025

International experts urge the reclassification of postpartum psychosis to improve treatment

An international panel of leading women's mental health experts – including UVA Health's Jennifer Payne, MD – is calling to reclassify postpartum psychosis as its own category of mental illness to improve the care new mothers receive.

3 Nov 2025

Fewer women participate in cardiac rehabilitation, despite a slew of benefits

For someone who has heart surgery or experiences a major cardiovascular event, cardiac rehabilitation can significantly improve their short and long term recovery.

3 Nov 2025

Long-term use of melatonin supplements linked to higher risk of heart failure and death

Long-term use of melatonin supplements, often used to promote sleep and address insomnia, was associated with a higher risk of heart failure diagnosis, heart failure hospitalization and death from any cause in chronic insomnia, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2025.

3 Nov 2025

Mental and physical health conditions can be traced back to a shared risk factor

Mental and physical health conditions in children and adolescents are often linked and can be traced back to a shared risk factor. According to new research from örebro University.

3 Nov 2025

The nation’s largest food aid program is about to see cuts. Here’s what you should know.

The Trump administration's overhaul of the nation's largest food assistance program will cause millions of people to lose benefits, strain state budgets, and pressure the nation's food supply chain, all while likely hindering the goals of the administration's "Make America Healthy Again" platform, according to researchers and former federal officials.

31 Oct 2025

New $4.4 million grant funds first study of prefrontal cortical stimulation in severe bipolar disorder

A University of Minnesota Medical School research team, led by Ziad Nahas, MD, has been awarded a $4.4 million grant for a first-in-the-world study of prefrontal cortical stimulation in severe bipolar disorder.

31 Oct 2025

GeneSight test-guided treatment leads to faster remission and response in patients with depression

Myriad Genetics, Inc., a leader in molecular diagnostic testing and precision medicine, today announced a post-hoc analysis of the Precision Medicine in Mental Health Care (PRIME) study showed that treatment informed by the GeneSight® test led to faster initial remission and response in patients with Major Depressive Disorder (MDD).

31 Oct 2025

How early diabetes management influences long-term outcomes

Could slightly elevated blood sugar levels lead to serious health problems in the future? A single patient's question sparked nearly a decade of research leading to the development of a landmark model that could shape how clinicians and researchers understand and manage diabetes across the US.

30 Oct 2025

Dance alleviates perceived symptoms of depression, study finds

Dance as a performative art form alleviates perceived symptoms of depression, helps to understand its root causes and promotes self-actualization, a recent study from the University of Eastern Finland found.

30 Oct 2025

Sertraline contributes to a modest improvement in core depression and anxiety symptoms

One of the most common antidepressants, sertraline, contributes to a modest improvement in core depression and anxiety symptoms, including low mood, within two weeks, finds a new analysis of a major clinical trial led by UCL researchers.

30 Oct 2025

Babies' gut bacteria could play a role in programming brain circuits tied to emotional health

A child's early gut microbiome may influence their risk of developing depression, anxiety or other internalizing symptoms in middle childhood, according to a new UCLA Health study.

30 Oct 2025

Low-cost biosensor identifies altered protein levels associated with psychiatric disorders

Brazilian researchers have developed a low-cost, portable biosensor that can quickly identify a protein whose altered levels are associated with psychiatric disorders, such as depression, schizophrenia, and bipolar disorder.

30 Oct 2025

Study highlights high prevalence of non-coeliac gluten sensitivity lacking clear markers

Around one in ten people worldwide report gastrointestinal and other symptoms such as fatigue and headache after eating foods containing gluten or wheat despite not having a diagnosis of either coeliac disease or wheat allergy, finds a large systematic review and meta-analysis published online in Gut.

29 Oct 2025

Mount Sinai receives $4.5 million grant to investigate neural mechanisms underlying bipolar disorder

The Icahn School of Medicine at Mount Sinai is pleased to announce it has received a three-year, $4.5 million grant from BD2: Breakthrough Discoveries for thriving with Bipolar Disorder to investigate the neural mechanisms underlying bipolar disorder and pioneer novel neuromodulation-based treatment strategies.

28 Oct 2025

Reducing prescriptions of sleep drugs in older adults could provide health and economic benefits

Millions of older Americans suffering from insomnia regularly use prescription sleep medications, despite the risk of serious side effects-such as falls, broken bones

28 Oct 2025