Depression

Depression is a serious medical illness that involves the brain. It's more than just a feeling of being "down in the dumps" or "blue" for a few days. If you are one of the more than 20 million people in the United States who have depression, the feelings do not go away. They persist and interfere with your everyday life.

Clinical Depression: Diagnosis, Causes & Treatment

Depression is a clinical condition that, contrary to popular opinion, cannot simply be overcome with time and it needs to be treated.

5 Facts You May Not Know About Depression

Antidepressants and Weight Changes

Intrusive Thoughts and Depression

Situational Depression: Symptoms, Causes, Treatments

How Does Your Diet Affect Depression?

Food Insecurity and Depression

Causes of Depression

Supporting Children with Mental Health Disorders

Treatment Options for Children with Depression

How Can I Tell if My Child is Depressed?

How is Depression in Children Diagnosed?

See more featured articles »

Depression and Sleep Length

The Science Behind the Winter Blues: Understanding Seasonal Affective Disorder

Can Depression and Anxiety Occur Together?

Depression in children

Treatment of Depression

Link Between Chronic Illness and Depression

Genes and Depression

Ghrelin and Depression

Depression Diagnosis

Prisoner Depression and Low Mood

Contributing Factors to Post-Adoption Depression

Symptoms of Depression

Latest Depression News and Research

GLP-1 medications linked to reduced psychiatric hospital visits

GLP-1 medications used to treat diabetes and obesity were associated with a reduced need for hospital care and sickness absence due to psychiatric reasons, a new study shows.

18 Mar 2026

Precise application of radio waves could help counter neurological conditions

A new study found that precise application of radio waves can change the activity of brain cells in ways that could counter neurological conditions.

18 Mar 2026

Burnout crisis demands science-based strategies beyond self-care solutions

Burnout is at an all-time high, with some studies saying two-thirds of employees now cite job burnout as a major challenge.

18 Mar 2026

More US adolescents are obese but fewer are trying to lose weight

The rising obesity rates in American adolescents, coupled with declining weight-loss efforts, signal urgent needs for targeted public health interventions.

18 Mar 2026

New microbiome therapy improves autism symptoms in children

This study evaluates a new fecal microbiota transplant method, revealing significant symptom improvements in children with autism without invasive procedures.

18 Mar 2026

Study finds common brain mechanism behind different anesthesia drugs

When patients undergo general anesthesia, doctors can choose among several drugs. Although each of these drugs acts on neurons in different ways, they all lead to the same result: a disruption of the brain's balance between stability and excitability, according to a new MIT study.

17 Mar 2026

Physical activity may reshape brain effects of childhood trauma

New research indicates that the long-term neurological impact of childhood trauma is not permanently etched onto the brain.

17 Mar 2026

Continuous Medicaid coverage lowered postpartum uninsurance, but disparities remain

Postpartum uninsurance declined among Black women in non-expansion states during the COVID-19 continuous Medicaid coverage policy, but racial gaps persisted, according to a new study at Columbia University Mailman School of Public Health.

17 Mar 2026

Psychiatrists’ use of biomarkers could open a new window into mental health diagnoses

Amanda Miller was 30 and pregnant with her second child in Hershey, Pennsylvania, when she developed depression.

17 Mar 2026

Study maps gene activity linked to neurotransmission in living brains

Researchers have identified a distinct and reproducible gene expression program associated with neurotransmission in the living human brain, offering unprecedented insight into the molecular mechanisms that support human cognition, emotion, and behavior.

16 Mar 2026

Childhood stress may lead to digestive issues later in life

Early life stress may lead to digestive issues later in life, driven by changes in the gut and sympathetic nervous systems, according to a new study published in the journal Gastroenterology.

16 Mar 2026

Largest review finds no mental health benefits of medicinal cannabis

A landmark Lancet Psychiatry paper published today – the largest-ever review of the safety and efficacy of cannabinoids across a range of mental health conditions – found no evidence that medicinal cannabis is effective in treating anxiety, depression or post-traumatic stress disorder (PTSD).

16 Mar 2026

App-based therapy helps men improve control over premature ejaculation

A smartphone app designed to tackle the underlying psychological causes of premature ejaculation can significantly improve sex life and delay ejaculation, while offering a way to reduce stigma around the condition, say researchers.

13 Mar 2026

Study identifies seven distinct types of hyperarousal across mental disorders

Hyperarousal plays an important role in mental disorders. It influences the severity of insomnia, depression, anxiety, post-traumatic stress disorder (PTSD), and ADHD.

12 Mar 2026

International urology conference showcases advancements in prostate cancer diagnostics

Nearly 300 abstracts on prostate cancer research from around the world will be presented at the European Association of Urology Congress (EAU26), taking place in London from 13–16 March 2026.

12 Mar 2026

Multiple concussions linked to slightly worse health in former college athletes

In former college athletes, having had three or more concussions was associated with slightly worse physical, mental, behavioral and cognitive health five years after graduation, according to an article published March 11, 2026, in Neurology, the medical journal of the American Academy of Neurology.

11 Mar 2026

Clinical trial to assess safety, efficacy of new implant for male stress urinary incontinence

Urologists at Vanderbilt Health are enrolling men with stress urinary incontinence (SUI) in a clinical trial named SOPHIA2 to assess the safety and efficacy of the UroActive implant, following an investigational device exemption clearance from the U.S. Food and Drug Administration and the French National Agency for the Safety of Medicines and Health Products.

11 Mar 2026

ADHD prescriptions surged during the COVID-19 pandemic

A study reveals COVID-19 reshaped stimulant prescribing patterns in Ontario, highlighting increased ADHD diagnoses and concerns over treatment appropriateness.

11 Mar 2026

New review reveals complex polygenic architecture underlying common epilepsies

An insightful mini-review published in Genomic Psychiatry synthesizes the rapidly expanding landscape of molecular genetic research on common epilepsies, assembling evidence from genome-wide association studies, whole-exome sequencing projects, and advanced statistical modeling to illuminate the polygenic architecture that underpins these heterogeneous neurological disorders.

10 Mar 2026

New review calls for biologically grounded approach to psychiatric diagnosis

A comprehensive invited review published today in Brain Medicine confronts one of the most persistent paradoxes in modern medicine: psychiatry remains the only major clinical discipline that diagnoses complex illness primarily through conversation and symptom checklists, while fields such as oncology and cardiology long ago embraced laboratory markers, imaging, and molecular profiling.

10 Mar 2026