Depression

Depression is a serious medical illness that involves the brain. It's more than just a feeling of being "down in the dumps" or "blue" for a few days. If you are one of the more than 20 million people in the United States who have depression, the feelings do not go away. They persist and interfere with your everyday life.

Clinical Depression: Diagnosis, Causes & Treatment

Depression is a clinical condition that, contrary to popular opinion, cannot simply be overcome with time and it needs to be treated.

Supporting Children with Mental Health Disorders

Food Insecurity and Depression

How Can I Tell if My Child is Depressed?

How Does Your Diet Affect Depression?

Can Depression and Anxiety Occur Together?

Causes of Depression

Depression Diagnosis

5 Facts You May Not Know About Depression

The Science Behind the Winter Blues: Understanding Seasonal Affective Disorder

Depression in children

Intrusive Thoughts and Depression

See more featured articles »

Prisoner Depression and Low Mood

Situational Depression: Symptoms, Causes, Treatments

Ghrelin and Depression

Symptoms of Depression

Treatment of Depression

Depression and Sleep Length

Treatment Options for Children with Depression

Genes and Depression

Contributing Factors to Post-Adoption Depression

Link Between Chronic Illness and Depression

Antidepressants and Weight Changes

How is Depression in Children Diagnosed?

Latest Depression News and Research

Feeling lonely impacts memory without accelerating mental decline

Loneliness affects the memory of older adults but does not speed up mental decline over time, suggests data from a major European study tracking more than 10,000 people over seven years.

14 Apr 2026

Study finds when parents are depressed may shape children’s mental health for decades

A long-running UK cohort study found that exposure to parental depression from pregnancy through young adulthood was linked to higher odds of depression and anxiety in adult offspring. Maternal depression in late pregnancy was uniquely associated with later psychotic symptoms, while paternal associations emerged more clearly from mid-childhood onward.

14 Apr 2026

A new model to break the cycle of chronic nightmares in children

The DARC-NESS model targets chronic nightmares in youth, promoting confidence and coping strategies to restore healthy sleep patterns and mental well-being.

14 Apr 2026

Categorization is fundamental and predictive across all brain processing

Challenging the classic view, two cognitive scientists argue in a new review that categorization is not a late, specialized stage of sensory processing.

13 Apr 2026

Study finds higher anxiety and depression in children with brain injuries

A new study, published today in JAMA Network Open, reveals that schoolage children and adolescents with medically diagnosed traumatic brain injury (TBI) have significantly higher rates of anxiety/depression, and strong family support and resilience helps alleviate some of it.

13 Apr 2026

Steroid hormones, BMI and stress influence puberty timing in girls

Higher levels of key steroid hormones-combined with elevated stress and body mass index (BMI)-are associated with earlier onset of puberty in girls, according to a new study at Columbia University Mailman School of Public Health.

13 Apr 2026

Threat-response in the brain's amygdala linked to sex-specific patterns of alcohol use

New research shows that the threat-response in the brain's amygdala (which processes emotions) is linked to different patterns of drinking by sex.

13 Apr 2026

Standard naloxone doses may not reverse newer synthetic opioid overdoses

A new study exposes challenges in reversing opioid overdoses with naloxone when potent synthetic drugs like fentanyl and sufentanil are involved, according to a study in the May 2026 issue of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA).

13 Apr 2026

Researchers map how menstrual cycle phases affect athletic performance

In a repeated-measures study of 18 eumenorrheic female athletes, half-squat strength was highest in the late follicular phase and around ovulation, while handgrip strength peaked in the late luteal phase. Psychological measures also shifted across the cycle, with lower vigor and higher fatigue and depression scores in the late luteal phase, supporting more individualized training monitoring.

12 Apr 2026

Maternal signals help synchronize babies’ circadian rhythms before birth

Humans and most other organisms have internal biological clocks that track the daily cycle of sunrise and sunset. These clocks help time our sleep, metabolism and other essential body functions over the course of a day, creating daily patterns called circadian rhythms.

11 Apr 2026

Brain pathways combine memory and reward to guide behavior

New research from the University of Maryland, Baltimore County (UMBC) reveals how two different parts of the brain's memory center team up in a key reward region to help mice-and likely humans-combine memories of places and contexts with the drive to pursue rewards.

10 Apr 2026

More steps cut chronic disease risk but cannot fully undo long sitting

Research shows higher daily step counts can mitigate risks of chronic diseases linked to prolonged sitting, emphasizing the need to reduce sedentary time.

10 Apr 2026

When omega-3 may help mental health and when they may not

Investigating omega-3 fatty acids, this review highlights their impact on mental health, inflammation, and the potential for therapeutic use in disorders.

10 Apr 2026

For many patients leaving the ICU, the struggle has only just begun

The accident happened in Pittsburgh on Nov. 16. Joseph Masterson, a lawyer who was just days from retiring at age 63, suffered cardiac arrest while driving, plowed into a guardrail, and lost consciousness.

10 Apr 2026

Higher optimism may lower dementia risk in older adults

Higher optimism in adults aged 70 and older was associated with a lower risk of developing dementia over up to 14 years of follow-up in the Health and Retirement Study. The association remained after adjustment for demographic factors, depression, health conditions, smoking, and physical activity, although the study was observational and cannot prove causation.

9 Apr 2026

Swapping passive screen time with mental activity may cut dementia risk

Research shows that mentally active sedentary behavior can reduce dementia risk, emphasizing the importance of daily cognitive engagement for brain health.

9 Apr 2026

Smoking during pregnancy raises children’s mental health risk

Smoking during pregnancy may increase children's mental health issues, with implications for internalizing and externalizing symptoms throughout development.

9 Apr 2026

Genetic overlap links psychiatric disorders with many physical ailments

For centuries, mental illness and physical disease have been viewed as two distinct categories, each with its own field of study, its own doctors, and its own menu of treatments.

8 Apr 2026

Study identifies a common brain activity pattern across psychedelics

Scientists have demonstrated, for the first time, that several psychedelic drugs – including psilocybin, LSD, mescaline, DMT and ayahuasca – produce a common pattern of brain activity despite their distinct chemistries.

8 Apr 2026

Duloxetine fails to prevent nerve damage caused by chemotherapy

A randomized trial conducted by the Alliance for Clinical Trials in Oncology with support from the National Cancer Institute has found that duloxetine, a medication commonly used to treat chronic pain and psychiatric conditions, does not prevent nerve damage caused by chemotherapy in patients with colorectal cancer.

8 Apr 2026