Endocrinology News and Research

Latest Endocrinology News and Research

Acute kidney injury predisposes elderly to serious kidney disease

Acute kidney injury (AKI) - which is often caused by trauma, illness, or surgery - predisposes elderly individuals to the most serious form of chronic kidney disease (CKD), known as end stage renal disease (ESRD), according to a study appearing in the January 2009 issue of the Journal of the American Society Nephrology (JASN).

19 Nov 2008

Genetic screening no better than traditional risk factors for predicting type 2 diabetes

Screening for a panel of gene variants associated with the risk for type 2 diabetes can identify adults at risk for the disorder but is not significantly better than assessment based on traditional risk factors such as weight, blood pressure and blood sugar levels.

19 Nov 2008

Household budget cutbacks in health care could have serious consequences

Household budget cutbacks are becoming commonplace as most Americans struggle to make ends meet, but experts warn that health care needs should not be among the forfeited services.

19 Nov 2008

Garlic drug treats diabetes

A drug based on a chemical found in garlic can treat diabetes types I and II when taken as a tablet, a study in the new Royal Society of Chemistry journal Metallomics says.

19 Nov 2008

Systems biology brings hope of speeding up drug development

Almost every day brings news of an apparent breakthrough against cancer, infectious diseases, or metabolic conditions like diabetes, but these rarely translate into effective therapies or drugs, and even if they do clinical development usually takes well over a decade.

19 Nov 2008

Obese women who undergo bariatric surgery decrease pregnancy-related health complications

Obese women who have weight loss surgery before becoming pregnant have a lower risk of pregnancy-related health problems and their children are less likely to be born with complications, according to a new RAND Corporation study.

18 Nov 2008

Pros and cons of gastric bypass surgery

Severely obese patients who underwent two different gastric bypass techniques had lost up to 31 per cent of their Body Mass Index (BMI) after four years, with no deaths reported among the 50 study subjects, according to the November issue of the British Journal of Surgery.

18 Nov 2008

Diabetes cost U.S. estimated $217.5 billion in 2007

According to findings from a National Diabetes Economic Barometer study, undiagnosed, pre-diabetes and diabetes cost the United States an estimated $217.5 billion in 2007 due to higher medical expenditures and lost productivity.

18 Nov 2008

Risk of maternal and newborn complications may be lower after bariatric surgery

A review of previously published studies suggests that rates of adverse outcomes for mothers or pregnant women and newborn babies, such as gestational diabetes and low birth weight, may be lower after bariatric surgery compared with pregnant women who are obese, according to an article in the November 19 issue of JAMA.

18 Nov 2008

New imaging technique tracks cancer-killing cells over prolonged period

Coaxing a patient's own cells to hunt down and tackle infected or diseased cells is a promising therapeutic approach for many disorders.

18 Nov 2008

Kinase inhibitors may offer new therapeutic approach for treatment of type 1 diabetes

Researchers at the University of California, San Francisco have reported that two common cancer drugs have been used to block and reverse type 1 diabetes in mice.

18 Nov 2008

Two common cancer drugs prevent, reverse type 1 diabetes

Two common cancer drugs have been shown to both prevent and reverse type 1 diabetes in a mouse model of the disease, according to research conducted at the University of California, San Francisco.

18 Nov 2008

$99 million medical education and research facility opened

NSW Minister for Health John Della Bosca and Vice-Chancellor and Principal Dr Michael Spence have officially opened the University of Sydney's new $99 million Kolling Building at Royal North Shore Hospital, providing a new purpose-built facility for medical researchers and clinical educators.

18 Nov 2008

Why HIV treatment makes people more susceptible to metabolic complications

Clinicians have known for some time that people treated for HIV also become much more susceptible to diabetes and heart disease.

17 Nov 2008

Breakthrough reveals first ever complete structure of a nuclear hormone receptor on human DNA

For decades, scientists have been studying nuclear hormone receptors to gain a better understanding of how they turn genes on and off throughout the body and how they function as key drug targets for a number of diseases, such as diabetes, breast cancer, osteoporosis and high cholesterol. A new UVA Health System study, led by Fraydoon Rastinejad, Ph.D., professor of pharmacology and director of the UVA Center for Molecular Design and published in the October 29 issue of Nature, reveals the first ever complete structure of a nuclear hormone receptor on human DNA – a discovery that now clears a new path for scientists to design more effective drugs with fewer associated health risks. “Dr. Rastinejad’s findings fundamentally change the way people all over the world will study how nuclear hormone receptors work and introduces a new platform for designing better drugs,” says Jim Garrison, Ph.D., professor of pharmacology at UVA Health System. Nuclear hormone receptors, including the peroxisome proliferator-activated receptors (PPARs), are proteins that sit on the surface of cells and bind to specific hormones such as estrogen, progesterone and thyroid hormone. Once the receptor binds to its hormone and its DNA regulatory element, it can cause a number of alterations in the cell, switching genes on and off. These switches control the continual regulation of the metabolic system and reproductive tissues, as well as the development and differentiation of skin, bone and behavioral centers in the brain. “PPARs are widely studied because they regulate the genes that produce fat cells, glucose, insulin, lipids and metabolism,” says Dr. Rastinejad. “That’s what makes them such good drug targets for diseases like diabetes. We can design drugs more rationally to bind to the PPAR nuclear receptor complex to help regulate these functions in the body.” A number of diabetes drugs, called insulin sensitizers, have been developed based on that knowledge, but now that scientists have a clear view into how these receptors bind and what shape they take the door is wide open for the development of better drugs. "After 40 years of nuclear receptor research, we finally can view the first full and complete structure of a nuclear receptor, thanks to Dr. Rastinejad’s break-though achievement,” says Bert W. O’Malley, Ph.D., professor and chairman, Department of Molecular and Cellular Biology at Baylor College of Medicine who is widely considered a top expert in the field.

17 Nov 2008

Study looks at investigational compound MK-677 in Alzheimer's disease

A new study shows that a drug that increases the release of growth hormone failed to slow the rate of progression of Alzheimer's disease in humans.

17 Nov 2008

Behavioral risk factors influence cancer risk among the elderly

Behavioral risk factors have a significant effect on cancer risk in the U.S. elderly population, according to research presented at the American Association for Cancer Research's Seventh Annual International Conference on Frontiers in Cancer Prevention Research.

17 Nov 2008

Sports fans may engage in riskier health related behaviors than non-sports fans

Ball park hot dogs may be putting sports fans at elevated health risk, researchers at UALR -- the University of Arkansas at Little Rock -- said in research presented last week.

16 Nov 2008

Pelvic girdle syndrome linked to diabetes

Diabetes appears to be linked with an increased risk of pelvic girdle syndrome. This is shown in a new study from the Norwegian Institute of Public Health and Akershus University Hospital.

16 Nov 2008

Community-based physical activity interventions found to be cost-effective

Community-based physical activity interventions designed to promote more active lifestyles among adults are cost-effective in reducing heart disease, stroke, colorectal and breast cancers, and type 2 diabetes, according to a study by the Centers for Disease Control and Prevention, with support from the Robert Wood Johnson Foundation.

16 Nov 2008