Endocrinology News and Research

Latest Endocrinology News and Research

How cells size up their growth opportunities

The intricate mechanisms that switch cell growth on and off are regulated by mammalian target of rapamycin (mTOR) protein complexes, which sense nutrients within the cell. When amino-acids are abundant, the protein complexes promote cellular growth, and when nutrients are scarce they signal that hard times are ahead to the cell. But just how nutrients regulate mTOR signaling to control size has remained a mystery. Now, scientists in the lab of Whitehead Member David Sabatini have found the first step in the process.

25 May 2008

Anti-rejection drug sirolimus may increase risk of diabetes after kidney transplant

For patients undergoing kidney transplantation, treatment with the anti-rejection drug sirolimus may lead to an increased risk of diabetes, reports a study in the July Journal of the American Society of Nephrology (JASN).

22 May 2008

Reducing blockage fails to improve access to the bloodstream for kidney dialysis

Reducing early blockages in bloodstream access for kidney failure treatment does not increase the likelihood that the access will function adequately for long-term treatments, according to a study funded by the National Institutes of Health. Results were published May 14, 2008, in the Journal of the American Medical Association.

22 May 2008

Scientists reveal the genetic determinants of fat storage in cells

New research by the Gladstone Institutes of Cardiovascular Disease (GICD) and the University of California, San Francisco (UCSF), has revealed the genetic determinants of fat storage in cells, which may lead to a new understanding of and potential treatments for obesity, diabetes, and heart disease. While scientists have long understood that lipid droplets contribute to fat build up in cells, the genes involved in droplet biology have been a focus of extensive research.

21 May 2008

Digital Healthcare appointed to major NHS Framework contract

NHS Connecting for Health, on behalf of the NHS, has appointed Digital Healthcare to the NHS Additional Supply Capability & Capacity (ASCC) Framework following open competition bids to provide additional capacity and capability in the supply of IT products and services to the NHS.

21 May 2008

When it comes to your teeth smoothies are roughies

Dentists are warning about the dangers of the currently popular fruit 'smoothies' and say they could lead to widespread tooth damage.

21 May 2008

New program promises to solve puzzling medical cases

A new research program in the U.S. promises to provide some answers for people suffering from mysterious diseases that have defied diagnosis.

21 May 2008

New clinical research and imaging centre for Bristol

The University and United Bristol Healthcare Trust (UBHT) are joining forces to establish a new state-of-the-art Clinical Research and Imaging Centre (CRIC) at St Michael's Hospital on St Michael's Hill

21 May 2008

Glycemic stability may be important key to recovery from critical illness

Widely varying blood glucose levels may pose as great a threat, or possibly a greater threat, to critically ill patients as high, but steady, glycemic levels, according to researchers in Saudi Arabia, who will present their findings at the American Thoracic Society's 2008 International Conference in Toronto on Tuesday, May 20.

21 May 2008

New blood test reveals risk for metabolic syndrome

University of Minnesota researchers have discovered that people with high oxidation levels of the low-density lipoprotein (LDL) particle that carries cholesterol throughout the blood are much more likely to develop metabolic syndrome - which can lead to a considerably increased risk of developing heart disease.

20 May 2008

Presidential candidates' health care advisers discuss role of Federal Government in providing coverage to U.S. residents

Advisers to the three major presidential candidates on Monday discussed the candidates' health care proposals and the role of government in health care during a forum hosted by Women in Government Relations, CQ HealthBeat reports.

20 May 2008

Erection problems may signal serious heart disease

Erectile dysfunction is always a matter of the heart, but new research shows that more than romance is at stake. Two new studies of men with type 2 diabetes found that erectile dysfunction (ED) was a powerful early warning sign for serious heart disease, including heart attack and death.

19 May 2008

NIH launches undiagnosed diseases program

The National Institutes of Health (NIH) today announced a new clinical research program that will aim to provide answers to patients with mysterious conditions that have long eluded diagnosis. Called the Undiagnosed Diseases Program, the trans-NIH initiative will focus on the most puzzling medical cases referred to the NIH Clinical Center in Bethesda, Md., by physicians across the nation.

19 May 2008

Bypass not to blame for heart patients' mental decline

Heart patients often experience lasting problems with memory, language, and other cognitive skills after bypass surgery. However, these problems aren't caused by the surgery itself or the pump used to replace heart function during surgery, a new study by Johns Hopkins researchers suggests. The findings may lead to better approaches to prevent cognitive decline regardless of which treatment heart disease patients receive.

19 May 2008

Blood pressure confusion for diabetics

For people with diabetes, high blood pressure poses a special threat, multiplying their risk of heart attacks, strokes and kidney problems.

19 May 2008

NYT examines limited options for disabled children who reach age 18

The New York Times on Wednesday examined how as "medical advances have allowed patients who might have died as children to survive into adulthood, the patients are falling into a void in a health care system that has yet to develop institutions for the young and 'medically fragile.'"

19 May 2008

51% of insured U.S. residents regularly take prescription drugs for chronic illnesses

Fifty-one percent of insured U.S. residents last year took one or more prescription drugs for chronic diseases, compared with 50% in the previous four years and 47% in 2001, according to a report released last Tuesday by Medco Health Solutions, the AP/Houston Chronicle reports.

19 May 2008

Obesity and unhealthy lifestyles linked to more complex urinary problems

People who are obese and lead unhealthy lifestyles are more likely to suffer from a larger number of urinary problems, according to a population-based study of more than 5,000 men and women published in the May issue of the UK-based urology journal BJU International.

15 May 2008

Research targets diabetes-related eye conditions

New research projects commissioned by the National Institute for Health Research's Health Technology Assessment (NIHR HTA) programme will evaluate the effectiveness and cost-effectiveness of different screening tests used in diabetic eye care.

15 May 2008

Pediatric obesity program effectively improves outcomes for kids

A multidisciplinary pediatric weight management program can improve the weight status of high-risk patients, according to Joseph Skelton, M.D., a pediatric gastroenterologist and Director of the Pediatric Weight Management program (called Brenner FIT) at Brenner Children's Hospital.

15 May 2008