Gastrointestinal Health News and Research

Latest Gastrointestinal Health News and Research

Gastrointestinal symptoms may interfere with nutritional management of ED patients

Eating disorders (ED) patients display a high prevalence of gastrointestinal symptoms and functional gastrointestinal disorders such as irritable bowel syndrome. These symptoms may interfere with their nutritional management. Ingestion of fructose-sorbitol (F-S) is an established means of gastrointestinal symptom provocation in irritable bowel syndrome patients.

20 Nov 2009

Embryonic stem cells raise hope of cellular replacement therapy for liver failure

Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure. There have been several protocols available for hepatic fate specification from ES cells, however, most of the protocols currently used result in low yield or purity of functional hepatocytes. Valproic acid (VPA), a histone deacetylase inhibitor, has been demonstrated to facilitate the hepatic differentiation of mesenchymal stem cells. However, little is know about whether VPA could induce the hepatic differentiation of ES cells.

19 Nov 2009

Book on pediatric IBD launched

Chronic inflammatory bowel disease (IBD) encompasses Crohn's disease, ulcerative colitis and indeterminate colitis. The distinct phenotype in pediatric and adolescent patients and the difference from adult IBD make early-onset IBD a unique subgroup requiring specific therapeutic considerations. In this book, leading experts from the USA, Europe and Israel present new data on the genetics, epidemiology, pathology and pathogenesis of pediatric IBD. Imaging and endoscopy in the diagnosis of IBD are also discussed.

19 Nov 2009

Report on unexplained liver haemorrhage after metastasis radiofrequency ablation published

Colorectal carcinoma is one of the most common cancers in the world. Approximately one in four of these patients have metastases at diagnosis, liver being the most common site involved. Although historically it was considered that liver metastases meant a very poor prognosis, today, due to improved systemic therapy, many patients will be candidates for local hepatic treatments such as surgery or less aggressive radiofrequency ablation.

19 Nov 2009

Reduction of serum bilirubin, the hallmark of successful biliary drainage

Biliary drainage is performed as a palliative treatment of hilar cholangiocarcinoma. The reduction of serum bilirubin is usually the hallmark of successful biliary drainage. However, some patients may have persistent jaundice or scanty bile output after biliary drainage.

19 Nov 2009

Study: EP4 agonist may reduce gastric bleeding and inflammation

Over 300 million patients use non-steroidal anti-inflammatory drugs (NSAIDs) in the world to treat pain, arthritis, fever and other diseases. Nearly 30% of the users suffer from gastric lesions and bleeding.

19 Nov 2009

Experimental study shows beneficial effects of Vardenafil on NSAID-induced gastric ulcer

Indomethacin has been proved by epidemiological and experimental studies to be closely associated with peptic ulcer development. Vardenafil is a potent phosphodiesterase 5 inhibitor and its effects on the gastric mucosa havenot been reported.

19 Nov 2009

Green tea prevents the development of hepatic fibrosis in rat model of DMN-induced liver fibrosis

Several studies have shown that lipid peroxidation stimulates collagen production in fibroblasts and hepatic stellate cells (HSC), and plays an important role in the development of liver fibrosis. Hepatoprotective effects of green tea against carbon tetrachloride, cholestasis and alcohol induced liver fibrosis were reported in many studies. However, the hepatoprotective effect of green tea in dimethylnitrosamine (DMN)-induced models has not been studied.

18 Nov 2009

Albireo completes A3309 phase 1b study in patients with chronic idiopathic constipation

Albireo today announced the completion of a phase 1b study showing a favorable tolerability and safety profile of A3309 in patients with chronic idiopathic constipation. In addition, the data revealed appropriate efficacy signals in this patient population. A3309 is a first in class compound developed for the treatment of chronic idiopathic constipation and constipation-predominant Irritable Bowel Syndrome (IBS-C).

18 Nov 2009

CONMED Linvatec produces the smallest Biocomposite Interference screw for fixation of ACL and PCL grafts

CONMED Corporation's CONMED Linvatec arthroscopy unit today announced the release of new sizes of its Matryx™ Biocomposite Interference Screw. These new screws represent the latest advance in biocomposite material technology that allows CONMED Linvatec to produce the smallest Biocomposite Interference screw available on the market today for primary fixation of ACL and PCL grafts.

17 Nov 2009

First phase of new electronic health record system launched at Trinity Center

NYU Langone Medical Center launched the first phase of its new electronic health record system last week at their multi-disciplinary faculty group practice at Trinity Center in lower Manhattan. The integrated system, powered by software from Epic Systems Corporation, provides a single platform from which physicians, staff and patients themselves can access and manage medical information.

17 Nov 2009

Scientists solve 50-year-old thalidomide puzzle

Research into the controversial drug thalidomide reveals that the mechanism through which the drug causes limb defects is the same process which causes it to damage internal organs and other tissues. The article, published in Bio-Essays, outlines the challenges surrounding thalidomide research and claims that confirmation of a 'common mechanism' could lead to new treatments for Leprosy, Crohn's Disease, AIDS and some forms of cancer..

17 Nov 2009

PPD, Janssen Pharmaceutica to develop therapeutic compounds for IBS and bacterial infections

PPD, Inc. today announced it has entered an agreement with Janssen Pharmaceutica N.V. to develop and commercialize two Phase II-ready therapeutic compounds, one to treat diarrhea-predominant irritable bowel syndrome (IBS-d) and the other to treat complicated skin and skin structure and respiratory infections.

17 Nov 2009

Bullseye Anatomic Cruciate Reconstruction System released

CONMED Corporation's CONMED Linvatec arthroscopy unit today announced the release of the Bullseye™ Anatomic Cruciate Reconstruction System, a novel guide system for anatomic cruciate ligament (ACL and PCL) reconstructions of the knee.

16 Nov 2009

Research team identifies five new gene regions that raise the risk of childhood-onset IBD

In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease (IBD), an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease.

16 Nov 2009

Ore Pharmaceutical Holdings reports financial results and provides operational updates for third quarter 2009

Ore Pharmaceutical Holdings Inc. today reported financial results and provided an operational update for the third quarter ended September 30, 2009.

13 Nov 2009

Warner Chilcott to offer 20,000,000 shares in secondary offering

Warner Chilcott plc today announced a 20,000,000 share secondary offering of its ordinary shares by certain selling shareholders. The selling shareholders include funds affiliated with Bain Capital Partners, DLJ Merchant Banking, J.P. Morgan Partners (advised by CCMP Capital) and Thomas H. Lee Partners, L.P., certain other institutional investors and members of the Company's senior management. The offering is being conducted as a public offering pursuant to an effective shelf registration statement under the Securities Act of 1933. The Company will not receive any proceeds from the sale of the shares but will pay the expenses of the offering.

13 Nov 2009

Medtronic launches an educational campaign to raise awareness of overactive bladder

Medtronic, Inc. today announced the kick-off of an educational campaign aimed at raising awareness among women of overactive bladder (OAB), a serious condition that can severely impact patients’ lives. This new campaign, conducted in partnership with leading patient advocacy groups focused on women’s health will help to raise awareness of the prevalence of bladder control problems and encourage patients to find effective treatment options – including and beyond medications.

13 Nov 2009

Clinical Care Options to provide online continuing medical education in "The Oncology Portal"

Clinical Care Options (CCO), a leader in the development of innovative interactive online, print, and live medical education for healthcare professionals, today announced its exclusive collaboration with Oncology Today(TM), a wholly owned subsidiary of US Oncology, Inc., to be the provider of online continuing medical education (CME) for the newly formed US Oncology's online clinician community, "The Oncology Portal."

13 Nov 2009

Positive results from Lexicon Pharmaceuticals' LX1031 Phase 2 study for IBS

Lexicon Pharmaceuticals, Inc. announced today that the company's investigational new drug, LX1031, a tryptophan hydroxylase (TPH) inhibitor, demonstrated positive results in clinically important parameters for the treatment of non-constipating irritable bowel syndrome (IBS).

13 Nov 2009

Gastrointestinal Health News and Research

Latest Gastrointestinal Health News and Research

Gastrointestinal symptoms may interfere with nutritional management of ED patients

Embryonic stem cells raise hope of cellular replacement therapy for liver failure

Book on pediatric IBD launched

Report on unexplained liver haemorrhage after metastasis radiofrequency ablation published

Reduction of serum bilirubin, the hallmark of successful biliary drainage

Study: EP4 agonist may reduce gastric bleeding and inflammation

Experimental study shows beneficial effects of Vardenafil on NSAID-induced gastric ulcer

Green tea prevents the development of hepatic fibrosis in rat model of DMN-induced liver fibrosis

Albireo completes A3309 phase 1b study in patients with chronic idiopathic constipation

CONMED Linvatec produces the smallest Biocomposite Interference screw for fixation of ACL and PCL grafts

First phase of new electronic health record system launched at Trinity Center

Scientists solve 50-year-old thalidomide puzzle

PPD, Janssen Pharmaceutica to develop therapeutic compounds for IBS and bacterial infections

Bullseye Anatomic Cruciate Reconstruction System released

Research team identifies five new gene regions that raise the risk of childhood-onset IBD

Ore Pharmaceutical Holdings reports financial results and provides operational updates for third quarter 2009

Warner Chilcott to offer 20,000,000 shares in secondary offering

Medtronic launches an educational campaign to raise awareness of overactive bladder

Clinical Care Options to provide online continuing medical education in "The Oncology Portal"

Positive results from Lexicon Pharmaceuticals' LX1031 Phase 2 study for IBS

Microbiology eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

Gastrointestinal Health News and Research

Latest Gastrointestinal Health News and Research

Microbiology eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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