Gene News and Research

Latest Gene News and Research

Patients with mutation in gene encoding CX3CR1 at higher risk of candidiasis

Candida albicans is one of the leading causes of hospital-acquired infections in immune compromised patients. The risk of both developing candidiasis and the clinical outcome of infection is variable among patients, and the host-dependent factors that contribute to patient susceptibility to C. albicans infection are poorly understood.

4 Nov 2013

Scientists make seminal breakthrough in understanding molecular basis of bile duct cancer

A team of scientists from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, Fundeni Clinical Institute (Romania) and Koen Kaen University (Thailand), have made a seminal breakthrough in understanding the molecular basis of bile duct cancer or cholangiocarcinoma, a rare but highly lethal form of liver cancer.

4 Nov 2013

Oncology drug development services: an interview with Dr. Jean-Pierre Wery, President of Crown Bioscience, Inc.

Crown serves pharmaceutical companies and biotech companies. We have two areas of focus: oncology and metabolic diseases. In the oncology space we focus on pre-clinical services. Essentially, we have all the tools to help our customers move from target discovery, target validation, to a clinical candidate.

31 Oct 2013

Interaction between fat cells and bacterial toxins can lead to chronic inflammation

Making fat cells immortal might seem like a bad idea to most people, but for a team of University of Iowa scientists it was the ideal way to study how the interaction between bacteria and fat cells might contribute to diabetes.

31 Oct 2013

Scientists uncover new mechanism through which gene expression is regulated

A new study by Weill Cornell Medical College scientists reveals a mechanism through which the expression of genes is controlled -- a finding that highlights genetic mutations that can impair the timing of gene expression.

31 Oct 2013

Scientists explain genetic and molecular basis of diabetes

In two comprehensive studies, scientists from Helmholtz Zentrum München, Ludwig-Maximilians-Universität München and Technische Universität München discovered new associations of two major type 2 diabetes risk genotypes and altered plasma concentrations of metabolic products.

31 Oct 2013

Scientists identify new toxic entity associated with dementia and motor neuron disease

A new toxic entity associated with genetically inherited forms of dementia and motor neuron disease has been identified by scientists at the UCL Institute of Neurology. The toxin is the result of a genetic mutation that leads to the production of RNA molecules which could be responsible for the diseases. The findings are published in the journal Acta Neuropathologica.

31 Oct 2013

Epigenetics may be useful target to stop the growth, spread and relapse of cancer

A review article by researchers at Boston University School of Medicine suggests that epigenetics may be a useful target to stop the growth, spread and relapse of cancer. The findings are published online in Volume 14 of the International Journal of Molecular Science.

31 Oct 2013

Listeria's resistance to disinfectants

Recent years have seen significant outbreaks of listeriosis on both sides of the Atlantic. Although the disease can usually be treated successfully, it is occasionally fatal, most frequently in pregnant women or immunocompromized people.

31 Oct 2013

New finding could help lead to better treatments for eczema

For the millions of people suffering from the intensely red, horribly itchy skin condition known as eczema, the only thing more maddening than their disease is the lack of understanding of what causes it, or makes it flare up from time to time.

31 Oct 2013

Researcher receives prestigious NCI grant to investigate unexplored area of cancer research

The National Cancer Institute's (NCI) new Provocative Questions research funding program has awarded a prestigious grant to a researcher at Roswell Park Cancer Institute (RPCI) to investigate a promising but neglected or unexplored area of cancer research.

31 Oct 2013

Researchers overcome obstacle to using viruses to deliver therapeutic genes

Scientists in The Research Institute at Nationwide Children's Hospital have found a way to overcome one of the biggest obstacles to using viruses to deliver therapeutic genes: how to keep the immune system from neutralizing the virus before it can deliver its genetic payload. In a study published recently in Molecular Therapy, researchers found that giving subjects a treatment to temporarily rid the body of antibodies provides the virus safe passage to targeted cells, allowing it to release a corrective or replacement gene to treat disease.

30 Oct 2013

Meta-analysis shows that XRCC1 Arg399Gln polymorphism may be a biomarker of glioma susceptibility

DNA damage is an important mechanism of glioma. X-ray cross-complementing group 1 (XRCC1) is a DNA repair gene that participates in the base excision repair pathway. To date, many studies have been performed to investigate the association between the XRCC1 polymorphisms and risk of cancers such as breast cancer, and gastroesophageal cancer, but the number of studies that focused on glioma is relatively small.

30 Oct 2013

New research reveals genetic link that connects family members with autism

Lorenzo Miodus-Santini an 11-year-old sixth-grader from Princeton, who was classified as autistic at only 13 months old, was never a big talker. As an infant he didn't babble or coo. When he was a toddler beginning to speak, he would learn one word but forget another.

30 Oct 2013

Queen's University is lead partner in £6M global research program to develop new ways to treat CF

Queen's University Belfast is a lead partner in a new -6 million (euro) global research programme to develop new ways to treat Cystic Fibrosis.

30 Oct 2013

Blood levels of microRNAs may serve as diagnostic tool for thyroid cancer, but more research needed

A new analysis has found that the presence of short segments of genetic material (known as microRNA) within papillary thyroid cancer tumors suggests a likelihood of recurrence after patients undergo surgery.

29 Oct 2013

Current drugs may harbor small-cell lung cancer promise

Scientists have identified several existing non-oncology drug classes that may have potential as a treatment for small-cell lung cancer, especially for patients with chemoresistant and metastatic disease.

28 Oct 2013

Study confirms the "seed and soil" theory of metastasis

Oncologists have long puzzled over the fact that after cancer treatment, single cancer cells that are dispersed throughout the body - so-called disseminated tumor cells - are quick to grow and form secondary tumors called metastases in certain organs, while in other organs they metastasize more slowly, sometimes decades later. Such is the case with head and neck squamous cell carcinoma cells, which remain dormant when lodged in bone marrow but rapidly form tumors when they make their way into the lungs.

28 Oct 2013

International researchers identify 11 new genes linked to Alzheimer's disease

An international group of researchers has identified 11 new genes that offer important new insights into the disease pathways involved in Alzheimer's disease. The highly collaborative effort involved scanning the DNA of over 74,000 volunteers-the largest genetic analysis yet conducted in Alzheimer's research-to discover new genetic risk factors linked to late-onset Alzheimer's disease, the most common form of the disorder.

28 Oct 2013

Two related genes underlie development of two rare bone tumours in nearly 100% of patients

Scientists have made a rare discovery that allows them to attribute two types of tumour almost entirely to specific mutations that lie in two related genes.

28 Oct 2013

Gene News and Research

Latest Gene News and Research

Patients with mutation in gene encoding CX3CR1 at higher risk of candidiasis

Scientists make seminal breakthrough in understanding molecular basis of bile duct cancer

Oncology drug development services: an interview with Dr. Jean-Pierre Wery, President of Crown Bioscience, Inc.

Interaction between fat cells and bacterial toxins can lead to chronic inflammation

Scientists uncover new mechanism through which gene expression is regulated

Scientists explain genetic and molecular basis of diabetes

Scientists identify new toxic entity associated with dementia and motor neuron disease

Epigenetics may be useful target to stop the growth, spread and relapse of cancer

Listeria's resistance to disinfectants

New finding could help lead to better treatments for eczema

Researcher receives prestigious NCI grant to investigate unexplored area of cancer research

Researchers overcome obstacle to using viruses to deliver therapeutic genes

Meta-analysis shows that XRCC1 Arg399Gln polymorphism may be a biomarker of glioma susceptibility

New research reveals genetic link that connects family members with autism

Queen's University is lead partner in £6M global research program to develop new ways to treat CF

Blood levels of microRNAs may serve as diagnostic tool for thyroid cancer, but more research needed

Current drugs may harbor small-cell lung cancer promise

Study confirms the "seed and soil" theory of metastasis

International researchers identify 11 new genes linked to Alzheimer's disease

Two related genes underlie development of two rare bone tumours in nearly 100% of patients

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