Gene News and Research

Latest Gene News and Research

New mechanism may alter principle understandings of molecular interactions within a cell's nucleus

Scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory, with collaborators from Harvard University, the University of Madrid, Princeton University, and the University of Zurich, have discovered a new mechanism that may alter principle understandings of molecular interactions within a cell's nucleus.

11 Oct 2012

Six-gene signature can predict survival in men with aggressive prostate cancer

Researchers from Mount Sinai School of Medicine have identified a six-gene signature that can be used in a test to predict survival in men with aggressive prostate cancer, according to new research published in the October issue of The Lancet Oncology.

11 Oct 2012

TSRI scientists identify new gene variants closely associated with bipolar disorder

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified small variations in a number of genes that are closely linked to an increased risk of bipolar disorder, a mental illness that affects nearly six million Americans, according to the National Institute of Mental Health.

11 Oct 2012

Spanish and British scientists design new blood test to identify aggressive prostate cancer

Scientists from the Spanish National Cancer Research Centre (CNIO) in Madrid, along with British colleagues from the Institute for Cancer Research (ICR) and the Royal Marsden NHS Foundation Trust, have developed a test that studies genetic patterns in blood cells to detect advanced-stage prostate cancer.

10 Oct 2012

Researchers identify two new small 'chaperone' molecules that may treat Schindler/Kanzaki disease

University of Massachusetts Amherst researchers, experts in revealing molecular structure by X-ray crystallography, have identified two new small "chaperone" molecules that may be useful in treating the inherited metabolic disorder known as Schindler/Kanzaki disease.

10 Oct 2012

New screening method may lead to more efficient RNA drug development

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new method of screening more than three million combinations of interactions between RNA and small molecules to identify the best targets on RNA as well as the most promising potential drug compounds.

10 Oct 2012

EHRs enhance quality of patient care in community-based settings

A new study by Weill Cornell Medical College researchers, published in the Journal of General Internal Medicine, provides compelling evidence that electronic health records (EHRs) enhance the quality of patient care in a community-based setting with multiple payers, which is representative of how medicine is generally practiced across the United States.

10 Oct 2012

Modifying factors may be responsible for non-diabetic kidney disease in African-Americans

The high rate of non-diabetic kidney disease in African-Americans is strongly associated with variations in a particular gene. Yet, not everyone who inherits these variations develops the disease.

10 Oct 2012

Salivary-biomarker approach can identify individuals at future risk of PTSD, depression

Each year, more than a million Americans are at-risk of developing serious mental health problems after experiencing a terrifying event or serious physical injury. Once manifested, these psychiatric illnesses, such as post-traumatic stress disorder and depression, can be extremely crippling and difficult to treat and are a leading cause of disability in civilian, military and minority populations.

10 Oct 2012

Study compares gene expression levels in two key hippocampal regions affected by Alzheimer's

Researchers from the Computational Intelligence Group based at the Universidad Politécnica de Madrid's Facultad de Informática have used machine learning and data mining techniques to compare gene expresssion levels in Alzheimer's disease (AD) patients in two key regions of the hippocampus: the dentate gyrus, where the disease appears to have little or no effect, and the entorhinal cortex, where Alzheimer's disease produces major neuronal damage.

10 Oct 2012

Study identifies cellular adhesion molecules key to cancer metastasis

Although tumor metastasis causes about 90 percent of cancer deaths, the exact mechanism that allows cancer cells to spread from one part of the body to another is not well understood. One key question is how tumor cells detach from the structural elements that normally hold tissues in place, then reattach themselves in a new site.

10 Oct 2012

RMND1 gene mutations responsible for severe neurodegenerative disorders

Scientists at the Montreal Neurological Institute and Hospital - The Neuro, McGill University working with a team at Oxford University have uncovered the genetic defect underlying a group of rare genetic disorders.

10 Oct 2012

T2R38 taste receptor regulates immune defense of the human upper airway

The immune system protects the upper respiratory tract from bacterial infections, but the cues that alert the immune system to the presence of bacteria are not known. In this issue of the Journal of Clinical Investigation, researchers led by Noam Cohen at the University of Pennsylvania demonstrated that the bitter taste receptor T2R38 regulates the immune defense of the human upper airway.

9 Oct 2012

Study sheds light on fundamental cellular process

Scientists at the Gladstone Institutes have mapped the precise frequency by which genes get turned on across the human genome, providing new insight into the most fundamental of cellular processes-and revealing new clues as to what happens when this process goes awry.

9 Oct 2012

New blood test can read genetic changes in prostate cancer

Scientists have designed a blood test that reads genetic changes like a barcode - and can pick out aggressive prostate cancers by their particular pattern of gene activity.

9 Oct 2012

Genetic basis of uterine fibroids uncovered

A mutation located near the fatty acid synthase gene is associated with an increased predisposition for uterine leiomyomata or fibroids, suggest US study findings.

8 Oct 2012

Morphine inhibits BDNF protein, whereas cocaine enhances BDNF

Chronic morphine exposure has the opposite effect on the brain compared to cocaine in mice, providing new insight into the basis of opiate addiction, according to Mount Sinai School of Medicine researchers. They found that a protein called brain-derived neurotrophic factor (BDNF), which is increased in cocaine addiction, is inhibited in opioid addiction. The research is published in the October 5 issue of Science.

8 Oct 2012

Functional profiling using EVA/PCD doubles response rate and improves survival in NSCLC patients

Functional profiling using ex-vivo analysis of programmed cell death (EVA/PCD) doubles the response rate and improves time-to-progression and survival in patients with advanced lung cancer, according to a Phase II clinical trial conducted by investigators at Rational Therapeutics and the MemorialCare Todd Cancer Institute and published in the October issue of Anticancer Research.

8 Oct 2012

Researchers discover smallest and fastest-known RNA switches

A University of Michigan biophysical chemist and his colleagues have discovered the smallest and fastest-known molecular switches made of RNA, the chemical cousin of DNA. The researchers say these rare, fleeting structures are prime targets for the development of new antiviral and antibiotic drugs.

8 Oct 2012

NFKB1 gene variant may reduce risk of lung cancer

A variant in a gene involved with inflammation and the immune response is linked with a decreased risk of lung cancer. That is the finding of an analysis published early online in CANCER, a peer-reviewed journal of the American Cancer Society. The results add to the growing body of literature implicating these processes in the development of lung cancer.

8 Oct 2012

Gene News and Research

Latest Gene News and Research

New mechanism may alter principle understandings of molecular interactions within a cell's nucleus

Six-gene signature can predict survival in men with aggressive prostate cancer

TSRI scientists identify new gene variants closely associated with bipolar disorder

Spanish and British scientists design new blood test to identify aggressive prostate cancer

Researchers identify two new small 'chaperone' molecules that may treat Schindler/Kanzaki disease

New screening method may lead to more efficient RNA drug development

EHRs enhance quality of patient care in community-based settings

Modifying factors may be responsible for non-diabetic kidney disease in African-Americans

Salivary-biomarker approach can identify individuals at future risk of PTSD, depression

Study compares gene expression levels in two key hippocampal regions affected by Alzheimer's

Study identifies cellular adhesion molecules key to cancer metastasis

RMND1 gene mutations responsible for severe neurodegenerative disorders

T2R38 taste receptor regulates immune defense of the human upper airway

Study sheds light on fundamental cellular process

New blood test can read genetic changes in prostate cancer

Genetic basis of uterine fibroids uncovered

Morphine inhibits BDNF protein, whereas cocaine enhances BDNF

Functional profiling using EVA/PCD doubles response rate and improves survival in NSCLC patients

Researchers discover smallest and fastest-known RNA switches

NFKB1 gene variant may reduce risk of lung cancer

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