Gene News and Research

Latest Gene News and Research

Positive results from Alnylam’s ALN-TTR02 Phase I trial on TTR-mediated amyloidosis

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today the achievement of positive clinical results from its Phase I trial with ALN-TTR02, an RNAi therapeutic targeting the transthyretin (TTR) gene for the treatment of TTR-mediated amyloidosis.

16 Jul 2012

UMMS scientists identify new genetic mutation that causes familial ALS

A new genetic mutation that causes familial amyotrophic lateral sclerosis (ALS), a fatal neurological disorder also known as Lou Gehrig's Disease, has been identified by a team of scientists led by researchers at the University of Massachusetts Medical School (UMMS).

16 Jul 2012

IDH mutation drives aggressive form of acute myeloid leukemia

Many patients with acute myeloid leukemia (AML) share a mutation in a gene called IDH. A University of Colorado Cancer Center study published this week in the journal Leukemia & Lymphoma shows that this IDH mutation may be the first domino in a chain that leads to a more aggressive form of the disease.

16 Jul 2012

Researchers link newly discovered gene mutations to ALS

Researchers have linked newly discovered gene mutations to some cases of the progressive fatal neurological disease amyotrophic lateral sclerosis - ALS, also known as Lou Gehrig's disease. Shedding light on how ALS destroys the cells and leads to paralysis, the researchers found that mutations in this gene affect the structure and growth of nerve cells.

16 Jul 2012

Five recent Science and Nature papers shed light on elusive 'GPCRs'

Readers of the top-ranked scientific journals Science and Nature might have noticed a recent wave of articles, most recently in the July 13, 2012 issue of Science, with deep importance for biology and medicine.

14 Jul 2012

Scientists clone tannin gene in sorghum

They might be called a blessing or a curse -- tannins, which are present in certain sorghums, contain health-promoting antioxidant properties, but also provide a bitter taste and decreased protein digestibility. To better understand tannins, their role in sorghum and how they can be altered to improve sorghum's use as food and feed, a team of scientists led by Kansas State University and U.S. Department of Agriculture researchers, has cloned the tannin gene in sorghum.

14 Jul 2012

New paper documents discovery of novel lipids, including MC3

Alnylam Pharmaceuticals, a leading RNAi therapeutics company, and collaborators announced today the publication of a scientific paper documenting the discovery of novel lipids used in second generation lipid nanoparticles (LNPs) for systemic delivery of RNAi therapeutics.

14 Jul 2012

Two cellular proteins team up to provide steady supply of RBCs

Two cellular proteins team up to provide a steady supply of red blood cells (RBCs), according to a study by Lizhao Wu, PhD, of the University of Medicine and Dentistry of New Jersey-New Jersey Medical School, and colleagues.

14 Jul 2012

Researchers define interaction between two essential proteins that control inflammation

Researchers at the IRCM, led by geneticist Dr. Jacques Drouin, recently defined the interaction between two essential proteins that control inflammation.

14 Jul 2012

Five rare mutations in single gene increase chances of boys developing ASD

Researchers at Emory University School of Medicine have identified five rare mutations in a single gene that appear to increase the chances that a boy will develop an autism spectrum disorder (ASD).

13 Jul 2012

OncoMed commences dosing in OMP-54F28 Phase I clinical trial for advanced solid tumor cancers

OncoMed Pharmaceuticals, Inc., a clinical-stage company developing novel therapeutics that target cancer stem cells, or tumor-initiating cells, today announced that patient dosing has begun in a Phase I clinical trial of OMP-54F28 in patients with advanced solid tumor cancers.

13 Jul 2012

PGC-1alpha and TFEB provide two new therapeutic targets for Huntington's disease

In a paper published in the July 11 online issue of Science Translational Medicine, researchers at the University of California, San Diego School of Medicine have identified two key regulatory proteins critical to clearing away misfolded proteins that accumulate and cause the progressive, deadly neurodegeneration of Huntington's disease.

12 Jul 2012

Communication between brain and muscle cells is short-lived without LRP4 protein

Communication between the brain and muscle must be strong for us to eat, breathe or walk. Now scientists have found that a protein known to be on the surface of muscle cells must be present in both tissues to ensure the conversation is robust.

12 Jul 2012

BGI, BioMed Central launch GigaScience journal

BGI, the world's largest genome sequencing institute, and their publishing partner BioMed Central, a leader in scientific data sharing, announce the launch of a new journal, GigaScience, which publishes large-scale biological research in a unique format.

12 Jul 2012

Gene News and Research

Latest Gene News and Research

Positive results from Alnylam’s ALN-TTR02 Phase I trial on TTR-mediated amyloidosis

UMMS scientists identify new genetic mutation that causes familial ALS

IDH mutation drives aggressive form of acute myeloid leukemia

Researchers link newly discovered gene mutations to ALS

Five recent Science and Nature papers shed light on elusive 'GPCRs'

Scientists clone tannin gene in sorghum

New paper documents discovery of novel lipids, including MC3

Two cellular proteins team up to provide steady supply of RBCs

Researchers define interaction between two essential proteins that control inflammation

Five rare mutations in single gene increase chances of boys developing ASD

OncoMed commences dosing in OMP-54F28 Phase I clinical trial for advanced solid tumor cancers

PGC-1alpha and TFEB provide two new therapeutic targets for Huntington's disease

Communication between brain and muscle cells is short-lived without LRP4 protein

BGI, BioMed Central launch GigaScience journal

New drug combination could offer hope to children with neuroblastoma

Study details how resistance to targeted drug therapy emerges in colorectal cancers

Novel molecular mechanism responsible for most important symptom of major depression

Genes responsible for immune function are almost different in middle age than in early adulthood

Thrombopoietin mimetic offers aplastic anemia hope

PCR assay ‘superior’ to culture for neonatal sepsis, meningitis

eBook: Using iPSCs models for human disease research and drug discovery eBook

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

Automating research - solutions and best practices