Gene News and Research

Latest Gene News and Research

Discovery of new cell targets for preventing growth of breast and other tumors

Researchers at the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill have discovered new targets for cancer treatment aimed at blocking a key step in tumor progression.

23 Apr 2008

Functional magnetic resonance imaging reveals brain circuitry associated with social status

Human imaging studies have for the first time identified brain circuitry associated with social status, according to researchers at the National Institute of Mental Health (NIMH) of the National Institutes of Health.

23 Apr 2008

Pin1 is beneficial in Alzheimer's disease, detrimental to some forms of dementia

The most common form of dementia, Alzheimer's disease, and a relatively rare hereditary form of dementia, frontotemporal dementia with parkinsonism-17, share a common pathology: Both are the result of an overaccumulation of tau proteins, which form tangled lesions in the brain's neurons and eventually lead to the collapse of the brain cells responsible for memory.

22 Apr 2008

Environmental factors weigh heavily in modulating gene expression in humans

Score one for the nurture side of the nature vs. nurture debate, as North Carolina State University geneticists have shown that environmental factors such as lifestyle and geography play a large role in whether certain genes are turned on or off.

22 Apr 2008

Scientists solve mystery about critical mechanism of gene expression

Although letters representing the three billion pairs of molecules that form the "rungs" of the helical DNA "ladder" are routinely called the human "genetic code," the DNA they comprise transmits traits across generations in a variety of ways, not all of which depend on the sequence of letters in the code.

22 Apr 2008

Mechanism discovered that can send cells on the road to cancer

Using a common virus as a tool for investigating abnormal cell proliferation, a team led by scientists at Cold Spring Harbor Laboratory (CSHL) has succeeded in clarifying an intricate series of biochemical steps that shed light on a way that cancer can begin.

22 Apr 2008

New advance in use of oncolytic viruses as novel cancer treatments

Combining a herpes virus genetically altered to express a drug-enhancing enzyme with a chemotherapy drug effectively and safely reduced the size of highly malignant human sarcoma grafted into mice.

22 Apr 2008

Discovery of gene that may influence metastasis risk in breast cancer

Researchers have identified a pattern of gene activity in mice that may help to predict individual risk for breast cancer metastasis and survival in humans. A single gene, called bromodomain 4 (Brd4), regulates the expression of this pattern, also called a signature.

22 Apr 2008

Gene mutation helps protect against malaria

New research suggests that not everyone who is bitten by a malaria-infected mosquito develops life threatening health problems according to scientists at the University of Toronto.

21 Apr 2008

Researchers describe key molecule responsible for the immature state of the tumor vasculature

Immune therapies are considered very promising in cancer medicine: Tumor-fighting immune cells are supposed to invade tumor tissue and eliminate cancer cells right there. Although this works well in the test tube, clinical application often fails because immune cells are unable to get into the tumor tissue from the bloodstream in sufficient numbers.

21 Apr 2008

Can IT fuel the race to the $1,000 human genome?

Ever wonder if you have a genetic disposition to a certain disease, or why a medicine works for your friend, but not for you?

21 Apr 2008

Genentech updates on phase III study of Avastin plus chemo in first-line, advanced, non-squamous, non-small cell lung cancer

Genentech, Inc. has announced an update for the previously reported Roche-sponsored international Phase III clinical study (AVAiL) of Avastin (bevacizumab) in combination with gemcitabine and cisplatin chemotherapy, in patients with advanced, non-squamous, non-small cell lung cancer (NSCLC).

21 Apr 2008

Chronic inflammation triggers cell fusions that could protect neurons

Chronic inflammation triggers bone marrow-derived blood cells to travel to the brain and fuse with a certain type of neuron up to 100 times more frequently than previously believed, according to a new study from the Stanford University School of Medicine.

20 Apr 2008

GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure

About 40 percent of African-Americans have a genetic variant that can protect them after heart failure and prolong their lives, according to research conducted at Washington University School of Medicine in St. Louis and collaborating institutions.

20 Apr 2008

A genetic variation mimics effect of heart failure medications - may explain why beta-blockers do not work for all patients

A genetic variation, found predominantly in African Americans, protects some people with heart failure, enabling them to live longer than expected. That's the conclusion of a research team led by investigators at the University of Maryland School of Medicine in Baltimore and the Washington University School of Medicine in St. Louis.

20 Apr 2008

Drinking and smoking brings dementia on earlier

The latest research from the U.S. suggests that people who are heavy drinkers and smokers develop Alzheimer's disease six to seven years earlier than those who do not smoke or drink.

20 Apr 2008

Discovery of method for clamping down on a cancer-promoting enzyme

There are many pathways that allow an errant gene to turn a cell cancerous, and a number of these pathways go through a single enzyme called the p21-activated kinase 1, or PAK1.

18 Apr 2008

Vitamin D and the risk of developing breast cancer

A connection between vitamin D level and the risk of developing breast cancer has been implicated for a long time, but its clinical relevance had not yet been proven.

18 Apr 2008

Cutting-edge surgical training facility to open at the University of Sydney

A new facility for the training of the next generation of microsurgeons in both molecular biology and advanced surgical techniques will be officially opened by the Governor of NSW, Her Excellency Professor Marie Bashir AC CVO, at the University of Sydney on Tuesday 22 April.

17 Apr 2008

Inherited cancer gene mutation more common than formerly believed

A gene mutation responsible for the most common form of inherited colon cancer is older and more common than formerly believed, according to a recent study.

17 Apr 2008