Gene News and Research

Latest Gene News and Research

Aspirin use appears to reduce the incidence of colon polyps

The association between regular aspirin use and a reduced risk of precancerous colon polyps may be strongest in those with particular genetic variants.

15 Mar 2005

Discovery of key molecule that controls the growth, spread and survival of pancreatic cancer cells

Pancreatic cancer kills 30,000 Americans every year. Not only is there no cure, but there are no effective treatments. That may change if a new finding by Mayo Clinic researchers continues to show promise.

15 Mar 2005

Selenium, vitamin E and the tomato nutrient lycopene have been shown to reduce prostate cancer

Greater levels of selenium, vitamin E and the tomato nutrient lycopene have been shown to reduce prostate cancer in one out of every four Caucasian males - those who inherit a specific genetic variation that's particularly sensitive to oxidative stress.

15 Mar 2005

Neuronal death and processing of Tau protein in Alzheimer’s Disease (AD)

In a research report recently published in the Journal of Alzheimer's Disease, published by IOS Press, a research group from the International School for Advanced Studies (ISAS\SISSA) in Trieste (Luisa Fasulo, Gabriele Ugolini e Antonino Cattaneo) showed that a processed form of tau protein induces neuronal death by apoptosis (programmed cell death) when expressed in cultured rat hippocampal neurons.

15 Mar 2005

Most comprehensive genome-wide experimental analyses of sense-antisense transcripts to date

A team of scientists led by Dr. Kuniya Abe from the RIKEN BioResource Center in Japan has performed one of the most comprehensive genome-wide experimental analyses of sense-antisense transcripts to date. Their findings are published in the April issue of the journal Genome Research.

15 Mar 2005

Good results in new lung cancer treatment

Interim analysis of a Phase III study of Avastin (bevacizumab) with paclitaxel and carboplatin chemotherapies in first-line non-squamous, non-small cell lung cancer (NSCLC) met its primary goal of improving overall survival, or a reduction in the risk of death, compared to chemotherapy alone.

15 Mar 2005

Gene therapy helps Lou Gehrig's disease

The most common form of motor neurone disease, called amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease, is caused when neurones in the spinal cord die, leading to muscle wasting and total paralysis.

14 Mar 2005

£800,000 to boost research into fighting viruses

A team of University of Glasgow scientists have received a grant of £800,000 from the Wellcome Trust to research a mechanism that blocks a critical step in the replication cycle of retroviruses. In the long term, the research could lead to the design of new therapeutic strategies or drugs against retroviruses, which cause diseases such as AIDS and certain leukemias.

14 Mar 2005

HIV-1 spread through six transmission lines in the UK

Contrary to the prevailing belief that the HIV epidemic in the UK can be traced back to one source, a new study suggests that HIV spread via at least six independent virus introductions and subsequent transmission chains.

14 Mar 2005

New biocentre which will revolutionise the way future medicines are produced

The University of Manchester has been awarded £6m to open a new biocentre which will revolutionise the way future medicines are produced – making them safer and more effective.

From The University of Manchester 14 Mar 2005

Molecule called DJ-1 is likely to be involved in the generation of human tumors

Scientists have discovered that a molecule called DJ-1 is likely to be involved in the generation of human tumors through negative regulation of the well-known tumor suppressor, PTEN. The research, published in the March issue of Cancer Cell, has important implications for determining the prognosis of some human cancers, and may prove to be a suitable target for cancer therapy.

14 Mar 2005

British restrictions on genetic testing and insurance extended

Britain's Health Secretary John Reid today announced that genetic test results used to predict possible future illness will not be used to deny people insurance.

14 Mar 2005

Genetic factors may play a significant role in the racial differences encountered in the epidemiology of breast cancer

A new review finds similarities between the clinical presentation and course of breast cancer in Africans and African-Americans, suggesting that genetic factors may play a significant role in the racial differences encountered in the epidemiology of breast cancer in America.

14 Mar 2005

Gene identified that confers susceptibility to age-related macular degeneration

By combining the tools of high-throughput biology and statistical genetics, scientists at Rockefeller University, Yale University School of Public Health and the National Eye Institute have identified a gene that confers susceptibility to age-related macular degeneration (AMD), the most common cause of vision loss in the United Sates for those over 60.

14 Mar 2005

Tumor-targeted immune cells cure prostate cancer without causing systemic immune suppression

In a major breakthrough in cancer gene therapy, a Northwestern University researcher has endowed immune cells with the ability to specifically target metastatic prostate cancer in mice without causing the toxic immune suppression that has been associated with earlier forms of cancer gene therapy.

14 Mar 2005

DNA weak links may provide clues to cancer biology

The chromosomes of mammals, including humans, contain regions that are particularly prone to breaking under conditions of stress and in cancer. Now, new research by geneticists at Duke University Medical Center finds that yeast cells also contain such weak links in DNA and begins to reveal the molecular characteristics of these links that might help to explain them.

13 Mar 2005

New way of looking at MicroRNA and how it controls gene expression

A group of scientists at The Scripps Research Institute is reporting a discovery that sheds light on an area of research fundamental to everything from the normal processes that govern the everyday life of human cells to the aberrant mechanisms that underlie many diseases, including cancer and septic shock.

13 Mar 2005

RNA interference as promising therapy for ALS

Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland have used RNA interference in transgenic mice to silence a mutated gene that causes inherited cases of amytrophic lateral sclerosis (ALS), substantially delaying both the onset and the progression rate of the fatal motor neuron disease.

13 Mar 2005

Gene for AMD has now been identified by researchers

Age-related macular degeneration (AMD) is a debilitating eye disease affecting about 15 million people in the United States.

13 Mar 2005

Active brains stave off Alzheimer's signs

Mice who keep busy playing with toys also keep their brains and bodies active; more importantly, they also have lower levels of the peptides and brain plaques associated with Alzheimer's disease, compared to mice raised in environments not "enriched" with chew toys, running wheels,and tunnels, according to a new study in the 11 March issue of the journal Cell.

13 Mar 2005