Gene News and Research

Latest Gene News and Research

Exome sequencing refines 46,XY DSD diagnosis

Exome sequencing can identify a likely genetic cause of 46,XY disorders of sex development in about a third of cases, report researchers.

1 Dec 2014

Promising new therapeutic strategy for chronic kidney disease

Chronic kidney disease (CKD) affects at least one in four Americans who are older than 60 and can significantly shorten lifespan. Yet the few available drugs for CKD can only modestly delay the disease's progress towards kidney failure. Now, however, a team led by researchers at the Perelman School of Medicine at the University of Pennsylvania, has found an aspect of CKD's development that points to a promising new therapeutic strategy.

1 Dec 2014

Baxter seeks FDA approval of BAX 855 for treatment of people with hemophilia A

Nektar Therapeutics reported that partner Baxter International Inc. today announced that the company has submitted a biologics license application (BLA) to the United States Food and Drug Administration for the approval of BAX 855, an investigational, extended half-life recombinant factor VIII (rFVIII) treatment for hemophilia A based on ADVATE [Antihemophilic Factor (Recombinant)].

From Baxter International Inc. 1 Dec 2014

Philips introduces new lung screening solution at RSNA 2014

Royal Philips today introduced a new lung screening solution designed to offer health care providers a faster and more definitive pathway to lung cancer detection and treatment. Making its debut at the 2014 Radiological Society of North America Annual Meeting in Chicago this week, this total solution is comprised of products and services that enable health care providers to implement and manage a comprehensive computed tomography (CT) lung screening program which tracks and guides patients across the health continuum.

1 Dec 2014

Different forms of ASIC1a gene associated with panic disorder

Panic disorder is a severe form of anxiety in which the affected individual feels an abrupt onset of fear, often accompanied by profound physical symptoms of discomfort.

1 Dec 2014

CCR5 receptor plays key role in driving prostate cancer metastases

Although prostate cancer can be successfully treated in many men, when the disease metastasizes to the bone, it is eventually lethal. In a study published online December 1st in the journal Cancer Research, researchers show that the receptor CCR5 best known for its role in HIV therapy, may also be involved in driving the spread of prostate cancer to the bone.

1 Dec 2014

Phenotyping human diseases in mice: an interview with Professor Carola Vinuesa

One of the main obstacles to finding effective therapies for human diseases has been our limited understanding of disease pathogenesis: we lack detailed knowledge of the cellular and molecular mechanisms that lead to the development of disease.

30 Nov 2014

DFG to establish new Collaborative Research Centres

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) will establish eight new Collaborative Research Centres (CRCs).

29 Nov 2014

Philips launches Ambient Experience patient in-bore solution to reduce patient anxiety during MRI scans

Royal Philips announced the launch of the Ambient Experience patient in-bore solution designed to reduce patient anxiety and movement during magnetic resonance imaging (MRI) examinations.

29 Nov 2014

New active substance effectively combats Philadelphia chromosome-positive leukaemia

Haematologists from Goethe University Frankfurt, working with a Russian pharmaceutical company, have developed a new active substance that effectively combats the most aggressive forms of Philadelphia chromosome-positive leukaemia.

29 Nov 2014

Finding could upend scientific consensus about when embryonic cells begin separating into cell types

Bioengineers at the University of California, San Diego have discovered that mouse embryos are contemplating their cellular fates in the earliest stages after fertilization when the embryo has only two to four cells, a discovery that could upend the scientific consensus about when embryonic cells begin differentiating into cell types.

28 Nov 2014

TET1 enzyme may be important target for cancer diagnostics, treatment

Mutations in the KRAS gene have long been known to cause cancer, and about one third of solid tumors have KRAS mutations or mutations in the KRAS pathway. KRAS promotes cancer formation not only by driving cell growth and division, but also by turning off protective tumor suppressor genes, which normally limit uncontrolled cell growth and cause damaged cells to self-destruct.

27 Nov 2014

Researchers show that iPS cells can be used to edit genetic mutations that cause DMD

Researchers at the Center for iPS Cell Research and Application, Kyoto University, show that induced pluripotent stem (iPS) cells can be used to correct genetic mutations that cause Duchenne muscular dystrophy (DMD).

27 Nov 2014

Pathology specialist publishes invited commentary on breast cancer gene screening

There has been much recent debate on the benefits and risks of screening for breast cancer using BRCA1 and BRCA2 mutations in the general adult population.

27 Nov 2014

Researchers find unusual role of lactate in metabolism of alveolar soft part sarcoma

Researchers from Huntsman Cancer Institute at the University of Utah discovered the unusual role of lactate in the metabolism of alveolar soft part sarcoma (ASPS), a rare, aggressive cancer that primarily affects adolescents and young adults. The study also confirmed that a fusion gene is the cancer-causing agent in this disease.

27 Nov 2014

New microbial analysis has implications for protecting environment, energy recovery and human health

An international team of scientists from the Translational Genomics Research Institute and The Luxembourg Centre for Systems Biomedicine have completed a first-of-its-kind microbial analysis of a biological wastewater treatment plant that has broad implications for protecting the environment, energy recovery and human health.

27 Nov 2014

Tufts University study explores relationship between transcription, expansions of DNA repeats

Researchers in human genetics have known that long nucleotide repeats in DNA lead to instability of the genome and ultimately to human hereditary diseases such Freidreich's ataxia and Huntington's disease.

26 Nov 2014

Leeds researchers identify gene associated with autism symptoms

Researchers at the University of Leeds have shed light on a gene mutation linked to autistic traits. The team already knew that some people with autism were deficient in a gene called neurexin-II.

26 Nov 2014

New Sophia DDM platform offers full BRCA1/2 analysis on a single NGS run

Sophia Genetics, the European leader in Clinical Genomics and Next Generation DNA Sequencing (NGS), has today launched a major upgrade to its Data Driven Medicine Platform (Sophia DDM), offering full BRCA1/2 analysis on a single NGS (Next Generation Sequencing) run, for the first time.

26 Nov 2014

Janssen submits YONDELIS NDA for treatment of advanced soft tissue sarcoma

PharmaMar announces that Janssen Research & Development, LLC has submitted a New Drug Application (NDA) for YONDELIS (trabectedin) to the U.S. Food and Drug Administration for the treatment of patients with advanced soft tissue sarcoma (STS), including liposarcoma and leiomyosarcoma subtypes, who have received prior chemotherapy including an anthracycline.

26 Nov 2014

Gene News and Research

Latest Gene News and Research

Exome sequencing refines 46,XY DSD diagnosis

Promising new therapeutic strategy for chronic kidney disease

Baxter seeks FDA approval of BAX 855 for treatment of people with hemophilia A

Philips introduces new lung screening solution at RSNA 2014

Different forms of ASIC1a gene associated with panic disorder

CCR5 receptor plays key role in driving prostate cancer metastases

Phenotyping human diseases in mice: an interview with Professor Carola Vinuesa

DFG to establish new Collaborative Research Centres

Philips launches Ambient Experience patient in-bore solution to reduce patient anxiety during MRI scans

New active substance effectively combats Philadelphia chromosome-positive leukaemia

Finding could upend scientific consensus about when embryonic cells begin separating into cell types

TET1 enzyme may be important target for cancer diagnostics, treatment

Researchers show that iPS cells can be used to edit genetic mutations that cause DMD

Pathology specialist publishes invited commentary on breast cancer gene screening

Researchers find unusual role of lactate in metabolism of alveolar soft part sarcoma

New microbial analysis has implications for protecting environment, energy recovery and human health

Tufts University study explores relationship between transcription, expansions of DNA repeats

Leeds researchers identify gene associated with autism symptoms

New Sophia DDM platform offers full BRCA1/2 analysis on a single NGS run

Janssen submits YONDELIS NDA for treatment of advanced soft tissue sarcoma

eBook: Using iPSCs models for human disease research and drug discovery eBook

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research