Immunology News and Research

Latest Immunology News and Research

Xencor begins XmAb5871 Phase 2 trials in patients with IgG4-RD and Systemic Lupus Erythematosus

Xencor, Inc., a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies for the treatment of autoimmune diseases, asthma and allergic diseases and cancer, today announced dosing the first patient in a Phase 2 trial of XmAb5871 in patients with IgG4-Related Disease (IgG4-RD).

8 Mar 2016

Complex biomarker tests for molecularly targeted therapies lack evidentiary standards

Potentially useful biomarker tests for molecularly targeted therapies are not being adopted appropriately into clinical practice because of a lack of common evidentiary standards necessary for regulatory, reimbursement, and treatment decisions.

7 Mar 2016

Teens with emotional disorders more likely to have asthma symptoms

A Henry Ford Hospital study has found that common asthma symptoms like waking up in the middle of the night and shortness of breath are associated with increased levels of stress and anxiety in teens with asthma.

7 Mar 2016

Omalizumab treatment significantly decreases colds in inner-city children with allergic asthma

Treatment with omalizumab significantly decreases the number of colds in inner-city children with allergic asthma, researchers reported at a press conference today at the American Academy of Allergy, Asthma and Immunology 2016 Annual Meeting in Los Angeles. Omalizumab, sold under the brand name Xolair, is an injectable antibody that can be used to treat asthma cases not controlled by inhaled corticosteroids.

7 Mar 2016

RUVICA (ibrutinib) capsules approved for treatment-naïve CLL patients

The U.S. Food and Drug Administration has approved IMBRUVICA (ibrutinib) capsules for treatment-naïve patients with chronic lymphocytic leukemia (CLL).

4 Mar 2016

Routine stress adversely affects women’s heart

While the number of men dying from a heart attack has been constantly decreasing during the past twenty years, the fatal risk particularly in young women has increased significantly. Gender medicine has already demonstrated that women exhibit different symptoms. A new insight shows that stress in the daily routine has particularly adverse effects on the hearts of women. This was emphasised by Alexandra Kautzky-Willer, Professor for Gender Medicine of MedUni Vienna, on the occasion of the impending International Women's Day on 8 March 2016.

4 Mar 2016

Scientists track rare potent antibodies in HIV-infected individual

One of the most crucial and elusive goals of an effective HIV vaccine is to stimulate antibodies that can attack the virus even as it relentlessly mutates.

4 Mar 2016

Researchers uncover new pathway for mitochondrial cell death

Researchers at St. Jude Children's Research Hospital have uncovered a new pathway for mitochondrial cell death that involves the protein BCL-2 ovarian killer, otherwise known as BOK. The discovery, which is described online in the journal Cell, may lead to new ways to trigger cell death in some types of cancer cells.

4 Mar 2016

New method uses MRT with Dixon sequence for accurate measurement of breast density

A high breast density is an independent risk factor for breast cancer. MRT is the safest method for breast cancer diagnosis and is now used for early diagnosis. Medical University Vienna researchers at the University Clinic for Radiology and Nuclear Medicine have now successfully developed a method for the exact measurement of breast density using magnetic resonance tomography (MRT) examinations with the Dixon sequence.

4 Mar 2016

Researchers aim to develop gentler treatment that 'tricks' cancer cells

The most common treatments for cancer are radiation and chemotherapy. However they have side effects and also damage healthy tissues. Moreover, their effectiveness is limited when the cancer has spread through out the body. Researchers at the Niels Bohr Institute are therefore working to develop a gentler treatment that 'tricks' the cancer cells, which would absorb a cytotoxin and therefore be destroyed, while healthy cells would remain unaffected. The results are published in the scientific journal, Scientific Reports.

2 Mar 2016

Air pollution increases risk of preterm birth for asthmatic pregnant women

Pregnant women with asthma may be at greater risk of preterm birth when exposed to high levels of certain traffic-related air pollutants, according to a study by researchers at the National Institutes of Health and other institutions.

2 Mar 2016

Report: One in two Americans affected by musculoskeletal condition

An estimated 126.6 million Americans (one in two adults) are affected by a musculoskeletal condition--comparable to the total percentage of Americans living with a chronic lung or heart condition--costing an estimated $213 billion in annual treatment, care and lost wages, according to a new report issued today by the United States Bone and Joint Initiative.

2 Mar 2016

P. gingivalis could be a novel risk factor for esophageal cancer

University of Louisville School of Dentistry researchers have found a bacterial species responsible for gum disease, Porphyromonas gingivalis, is present in 61 percent of patients with esophageal squamous cell carcinoma (ESCC).

27 Feb 2016

Researchers find way to boost the body's natural cancer-killing cells

The immune cells, called natural killer cells, hunt and destroy foreign cells in the body, including cancer cells that spread and form tumours.

27 Feb 2016

TTR protein causes autoimmune reaction in joints of juvenile idiopathic arthritis patients

Juvenile idiopathic arthritis, or JIA, is the most common form of childhood arthritis. It appears to be an autoimmune disease, caused by antibodies attacking certain proteins in a person's own tissue. But no "autoantigens" -- the proteins triggering an immune attack -- have been linked to JIA.

27 Feb 2016

Baxalta seeks FDA approval for ADYNOVATE to treat children with hemophilia A and for use in surgical settings

Baxalta Incorporated, a global biopharmaceutical leader dedicated to delivering transformative therapies to patients with orphan diseases and underserved conditions, announced today that it has submitted supplemental Biologics License Applications (sBLAs) to the U.S. Food and Drug Administration seeking approval for the use of ADYNOVATE [Antihemophilic Factor (Recombinant), PEGylated] to treat children under the age of 12 with hemophilia A and for use in surgical settings.

26 Feb 2016

Rigel begins fostamatinib Phase 2 trial for treatment of patients with autoimmune hemolytic anemia

Rigel Pharmaceuticals Inc. today announced that it has initiated a Phase 2 clinical trial to evaluate fostamatinib, its oral SYK inhibitor, as a potential treatment for autoimmune hemolytic anemia (AIHA).

25 Feb 2016

Research: Impaired immune response significantly involved in rare autoimmune diseases

In the context of the multicentre EU project "INTRICATE" under the management of Renate Kain of the Clinical Institute for Pathology of MedUni Vienna, the effects of infections on the generation of rare autoimmune diseases such as granulomatous polyangiitis (GPA), a systemic disease of the vascular system, are examined.

25 Feb 2016

Researchers launch clinical trials to test novel cellular-immunotherapy to treat three types of blood cancer

Cancer immunology is based upon boosting the body's own immune system to vanquish malignancies. It is among the fastest growing areas of oncology research. Researchers at UC San Diego Moores Cancer Center have launched three clinical trials to test the safety and efficacy of a novel cellular-immunotherapy that uses modified T cells - one of the immune system's primary weapons - to treat three different types of blood cancer that often defy existing therapies.

24 Feb 2016

Researchers discover new JE virus transmission route

Japanese Encephalitis (JE) virus causes serious inflammation of the brain in people and fertility problems in pigs. Mosquitoes were previously the only known transmission route. However, the virus can also be spread from pig to pig by direct contact, and this could enable it to circulate in pigs during the mosquito-free winter season.

24 Feb 2016

Immunology News and Research

Latest Immunology News and Research

Xencor begins XmAb5871 Phase 2 trials in patients with IgG4-RD and Systemic Lupus Erythematosus

Complex biomarker tests for molecularly targeted therapies lack evidentiary standards

Teens with emotional disorders more likely to have asthma symptoms

Omalizumab treatment significantly decreases colds in inner-city children with allergic asthma

RUVICA (ibrutinib) capsules approved for treatment-naïve CLL patients

Routine stress adversely affects women’s heart

Scientists track rare potent antibodies in HIV-infected individual

Researchers uncover new pathway for mitochondrial cell death

New method uses MRT with Dixon sequence for accurate measurement of breast density

Researchers aim to develop gentler treatment that 'tricks' cancer cells

Air pollution increases risk of preterm birth for asthmatic pregnant women

Report: One in two Americans affected by musculoskeletal condition

P. gingivalis could be a novel risk factor for esophageal cancer

Researchers find way to boost the body's natural cancer-killing cells

TTR protein causes autoimmune reaction in joints of juvenile idiopathic arthritis patients

Baxalta seeks FDA approval for ADYNOVATE to treat children with hemophilia A and for use in surgical settings

Rigel begins fostamatinib Phase 2 trial for treatment of patients with autoimmune hemolytic anemia

Research: Impaired immune response significantly involved in rare autoimmune diseases

Researchers launch clinical trials to test novel cellular-immunotherapy to treat three types of blood cancer

Researchers discover new JE virus transmission route

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