Metabolism News and Research

Latest Metabolism News and Research

Antibiotics accelerate metastatic bone growth in mice with melanoma by depleting intestinal flora

The use of broad-spectrum antibiotics in mice with malignant melanoma, an aggressive form of skin cancer, accelerated their metastatic bone growth, likely because the drugs depleted the mice's intestinal flora and weakened their immune response, according to a new study by researchers at Emory University in Atlanta.

12 Sep 2022

Blocking FNDC5 prevents cancer-induced cachexia in mice

The severe muscle atrophy and weakness commonly associated with cancer growth (i.e., cachexia) can be prevented simply by being deprived of FNDC5, the precursor of the exercise hormone irisin, researchers from the Indiana University School of Medicine have found.

12 Sep 2022

Study reveals two distinct types of obesity with physiological and molecular differences

A team led by Van Andel Institute scientists has identified two distinct types of obesity with physiological and molecular differences that may have lifelong consequences for health, disease and response to medication.

12 Sep 2022

Morning-loaded and evening-loaded diets produce similar weight loss, with no energy metabolism differences

There's the old saying in dieting that one must "breakfast like a king, lunch like a prince, and dine like a pauper," based on the belief that consuming the bulk of daily calories in the morning optimizes weight loss by burning calories more efficiently and quickly.

12 Sep 2022

Tumor-derived factors stimulate effector trogocytosis and inhibit CAR T cells

The immune system is equipped to respond not just to external invaders-;think viruses, bacteria, and parasites-;but also to internal threats, namely, cancer. Yet, frequently, malignancies overcome the immune system's defenses and evade detection.

12 Sep 2022

Molecular probes can track the progress of protein that misbehaves in neurodegenerative diseases

A team of researchers from the IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) has designed in silico "molecular probes" able to track the progress of a protein that misbehaves in different neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS) and Fronto-Temporal Dementia (FTD).

9 Sep 2022

St. Baldrick's Scholar grant awarded to CU researcher for investigating new drug to treat infant leukemia

As part of its ongoing efforts to eradicate childhood cancers, the St. Baldrick's Foundation has awarded University of Colorado Cancer Center member Kelly Faulk, MD, a St. Baldrick's Scholar grant to investigate a new method for treating infant leukemia.

9 Sep 2022

UT Southwestern scientists identify genetic mutations that contribute to nonalcoholic fatty liver disease

Using a genetic screening platform developed by a UT Southwestern Nobel Laureate, scientists with the Center for the Genetics of Host Defense at UT Southwestern Medical Center have identified genetic mutations that contribute to nonalcoholic fatty liver disease (NAFLD), providing a potential future target for therapeutic interventions.

9 Sep 2022

Early life exposure to antibiotics can have long-lasting effects on adult gut health

Preterm and low birth weight babies are routinely given antibiotics to prevent, not just treat, infections, which they have a high risk of developing.

9 Sep 2022

Understanding the molecular pathways that underly nutrient switch in starving cancer cells

Cancer cells often grow in environments that are low in nutrients, and they cope with this challenge by switching their metabolism to using proteins as alternative "food".

9 Sep 2022

Single amino acid change in TKTL1 protein underlies greater neuron production in modern humans than Neandertals

Researchers from Dresden uncover a greater neuron production in the frontal lobe during brain development in modern humans than Neandertals, due to the change of a single amino acid in the protein TKTL1.

9 Sep 2022

Supplementary folic acid associated with higher risk of COVID-19 diagnosis and mortality

In a recent study published in the journal BMJ Open, researchers investigated the impact of folic acid supplements and methotrexate, in combination or individually, on disease severity and mortality in coronavirus disease 2019 (COVID-19) cases.

8 Sep 2022

Physical activity may help improve outcomes for colon cancer patients after surgery

Physical activity may be associated with improved outcomes for patients undergoing postoperative treatment for Stage III colon cancer.

8 Sep 2022

Children of women with gestational diabetes and obesity more likely to develop ADHD

Children of women with gestational diabetes and obesity may be twice as likely to develop attention-deficit/hyperactivity disorder (ADHD) compared to those whose mothers did not have obesity, according to new research published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

8 Sep 2022

Newly discovered protein could help to improve fertility treatments

Scientists have discovered a new protein which helps sperm fuse to an egg and is fundamental for human fertilization.

8 Sep 2022

Researchers harness stem cells to study how Ebola virus infects and damages the liver

The Ebola virus was first identified in 1976 near the Ebola River in the Democratic Republic of the Congo. Since then, there have been periodic outbreaks of Ebola Virus Disease (EVD), mostly in Africa, resulting in 13,700 deaths worldwide.

8 Sep 2022

Study establishes link between Piezo1 and intracellular cholesterol levels during neural development

A new University of California, Irvine-led study reveals how mechanical forces and tissue mechanics influence the morphology of the developing brain, and establishes a direct link in neural stem cells between Piezo1, a mechanically-activated ion channel, and intracellular cholesterol levels during neural development.

8 Sep 2022

Study shows how feasible reductions in ultra-processed food consumption positively impact the nutritional quality of diets

Researchers assessed the association between consumption of ultra-processed food and dietary nutrient profiles.

8 Sep 2022

Scientists develop a model human gut microbiome

A team of US-based scientists has developed a novel bacterial community comprising 119 microbial species naturally found in the human body. The study is published in the journal Cell.

7 Sep 2022

Insights into molecular structure of protein assembly that plays key role in controlling cristae architecture

Energy supply is a vital component of economic life. And the complex interplay between society and economy is jeopardized whenever core services or key industrial sectors are at risk of failing because of energy supply problems.

7 Sep 2022

Metabolism News and Research

Latest Metabolism News and Research

Antibiotics accelerate metastatic bone growth in mice with melanoma by depleting intestinal flora

Blocking FNDC5 prevents cancer-induced cachexia in mice

Study reveals two distinct types of obesity with physiological and molecular differences

Morning-loaded and evening-loaded diets produce similar weight loss, with no energy metabolism differences

Tumor-derived factors stimulate effector trogocytosis and inhibit CAR T cells

Molecular probes can track the progress of protein that misbehaves in neurodegenerative diseases

St. Baldrick's Scholar grant awarded to CU researcher for investigating new drug to treat infant leukemia

UT Southwestern scientists identify genetic mutations that contribute to nonalcoholic fatty liver disease

Early life exposure to antibiotics can have long-lasting effects on adult gut health

Understanding the molecular pathways that underly nutrient switch in starving cancer cells

Single amino acid change in TKTL1 protein underlies greater neuron production in modern humans than Neandertals

Supplementary folic acid associated with higher risk of COVID-19 diagnosis and mortality

Physical activity may help improve outcomes for colon cancer patients after surgery

Children of women with gestational diabetes and obesity more likely to develop ADHD

Newly discovered protein could help to improve fertility treatments

Researchers harness stem cells to study how Ebola virus infects and damages the liver

Study establishes link between Piezo1 and intracellular cholesterol levels during neural development

Study shows how feasible reductions in ultra-processed food consumption positively impact the nutritional quality of diets

Scientists develop a model human gut microbiome

Insights into molecular structure of protein assembly that plays key role in controlling cristae architecture

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production