Metabolism News and Research

Latest Metabolism News and Research

Properties and pharmacokinetics an oral drug candidate for COVID-19 treatment

Researchers studied the preclinical PK) and in vitro ADME properties of GS-441524, a potential oral drug for COVID-19 treatment.

10 Feb 2022

Study tests efficacy of molnupiravir against SARS-CoV-2 VOCs in various animal models

A study published on the bioRxiv* preprint server evaluates molnupiravir against a panel of relevant VOCs using three efficacy models: primary human airway epithelium organoids, a ferret model of upper respiratory disease, and a Roborovski dwarf hamster model for severe COVID-19.

9 Feb 2022

Research may lead to the development of effective fasting-based therapies

Voluntary fasting, for example interval fasting, is beneficial to health for many people, depending on their individual condition. For example, controlled periods of starvation can prevent and improve diseases such as diabetes and obesity.

9 Feb 2022

Reviewing breath biomarkers for inflammatory respiratory diseases

The prevalence of inflammatory airway diseases such as lung cancer, chronic obstructive pulmonary disease (COPD) and asthma is on the rise internationally, placing strain on health systems around the world. Lung cancer is the leading cause of death of all cancers.

From Owlstone Medical Ltd 8 Feb 2022

Mechanical hearts can generate new muscle tissue in the failing human heart

Mechanical hearts spur some regeneration in dormant parts of failing hearts, according to a UT Southwestern pilot study that shows promise for developing regenerative heart therapies.

8 Feb 2022

Toxic goiter affects the brain more than previously thought

Toxic goiter affects the brain more than was previously known, a University of Gothenburg study shows, and involves volume changes occurring in central parts of the brain.

8 Feb 2022

Investigating taraxerol as a protease inhibitor against SARS-CoV-2

In a recent study posted to the Research Square preprint* server, a team of researchers investigated the toxicity and absorption, distribution, metabolism, and excretion (ADME) characteristics of a potent herbal drug, taraxerol, in the management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The paper is under consideration for publication in the Structural Chemistry journal.

7 Feb 2022

Selenium could boost learning and memory in aging brains

Selenium – a mineral found in many foods – could reverse the cognitive impact of stroke and boost learning and memory in aging brains, according to University of Queensland research.

7 Feb 2022

Cerebrovascular impairment persists months after severe acute COVID-19, UK study

Researchers in the United Kingdom have conducted an observational cohort study on hospitalized patients and have found that the degree of severity of acute coronavirus disease 2019 (COVID-19) predicts the occurrence of chronic cerebrovascular impairment. The study further suggests that the levels of cerebrovascular impairment are associated with worse cognitive, mental, and physical well-being.

7 Feb 2022

Study finds higher levels of oxytocin in men with hypersexual disorder

Men with hypersexual disorder may have higher levels of oxytocin in their blood than men without the disorder, according to a small study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

2 Feb 2022

Liver hormone suppresses alcohol consumption in primates, study shows

A hormone produced by the liver called fibroblast growth factor 21 (FGF21) suppresses alcohol consumption in primates, finds a study published February 1 in the journal Cell Metabolism.

1 Feb 2022

Researchers visualize protein machinery of respiration for the first time

Oxygen and sugar are the basis of life for animals, plants, fungi and many bacteria. The metabolic process called respiration makes it possible to convert food into energy for the cells.

31 Jan 2022

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

A University of South Florida Health preclinical study offers molecular insight into how activated protein C (APC) may improve aging patients' tolerance to reperfusion injury – a potentially adverse effect of treatment for ischemic heart disease.

31 Jan 2022

Study reveals potential mechanism for iron accumulation in the aging brain

Breakdowns in regulatory mechanisms cause iron to build up in the brain as organisms grow older, increasing oxidative stress and causing cellular damage, according to a Northwestern Medicine study published in the journal eLife.

31 Jan 2022

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

In a new study, a team of researchers discovered S-217622, a non-covalent SARS-CoV-2 3C-like protease (3CLpro) inhibitor clinical candidate for the treatment of COVID-19.

31 Jan 2022

Study reveals link between muscular dystrophy and sphingolipids

In a new study, the group of Johan Auwerx at EPFL's School of Life Sciences has made the first connection between muscular dystrophy and sphingolipids, a group of bioactive lipids. The study is published in Science Advances.

29 Jan 2022

New study offers valuable information on ocular drug metabolism and pharmacokinetics

Severe visual illnesses are increasing in our society, and effective treatments are missing for diseases as age-related macular degeneration, diabetic retinopathy, and glaucoma. Both industry and academia are highly interested to advance ocular drug discovery and development.

29 Jan 2022

Study identifies genetic link between early maturation and high aerobic performance in juvenile salmon

A study conducted at the University of Helsinki indicates that early sexual maturation and high aerobic performance in salmon have a genetic link that is already evident in juvenile salmon.

28 Jan 2022

Studying the effect of COVID-19 mRNA vaccine on human lung carcinoma epithelial cells using Raman spectroscopy and imaging

Researchers from the Lodz University of Technology have been investigating the effects of the mRNA COVID-19 vaccines on human lung carcinoma cells.

28 Jan 2022

Impact of DNA clearance on mortality in patients with severe COVID-19 infections

In a new study, researchers conducted activity-based proteomic profiling of patients who had severe SARS-CoV-2 infections to understand the impact of DNA clearance on mortality.

28 Jan 2022

Metabolism News and Research

Latest Metabolism News and Research

Properties and pharmacokinetics an oral drug candidate for COVID-19 treatment

Study tests efficacy of molnupiravir against SARS-CoV-2 VOCs in various animal models

Research may lead to the development of effective fasting-based therapies

Reviewing breath biomarkers for inflammatory respiratory diseases

Mechanical hearts can generate new muscle tissue in the failing human heart

Toxic goiter affects the brain more than previously thought

Investigating taraxerol as a protease inhibitor against SARS-CoV-2

Selenium could boost learning and memory in aging brains

Cerebrovascular impairment persists months after severe acute COVID-19, UK study

Study finds higher levels of oxytocin in men with hypersexual disorder

Liver hormone suppresses alcohol consumption in primates, study shows

Researchers visualize protein machinery of respiration for the first time

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

Study reveals potential mechanism for iron accumulation in the aging brain

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

Study reveals link between muscular dystrophy and sphingolipids

New study offers valuable information on ocular drug metabolism and pharmacokinetics

Study identifies genetic link between early maturation and high aerobic performance in juvenile salmon

Studying the effect of COVID-19 mRNA vaccine on human lung carcinoma epithelial cells using Raman spectroscopy and imaging

Impact of DNA clearance on mortality in patients with severe COVID-19 infections

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production