Metabolism News and Research

Latest Metabolism News and Research

Scientists imitate the Human Blood-retinal barrier on a microfluidic chip

For years scientists have sought to minimise Animal testing and speed up clinical trials. One alternative is the use of in vitro assays using live cells, but its effectiveness is limited, since it is difficult to reproduce interaction and interconnection between cells.

24 Jan 2018

Enzyme inhibitor and chemotherapy combination regresses glioblastoma

In animal experiments, a human-derived glioblastoma significantly regressed when treated with the combination of an experimental enzyme inhibitor and the standard glioblastoma chemotherapy drug, temozolomide.

24 Jan 2018

Scientists elucidate surprising dual function of ceramide synthase

Scientists at the University of Bonn have clarified a surprising dual function of ceramide synthase. The enzyme not only catalyzes a central step of the production of vital lipids. It also has the ability to turn genes involved in lipid metabolism on or off. The study is being published in the renowned journal Cell Reports.

24 Jan 2018

Women with PCOS likely to have less diverse gut bacteria, study reveals

Women who have a common hormone condition that contributes to infertility and metabolic problems tend to have less diverse gut bacteria than women who do not have the condition, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

23 Jan 2018

Metabolic shift can result in congestive heart failure

The heart derives its energy primarily from fatty acids. However, if a metabolic shift to other energy sources takes place, this can result in congestive heart failure, scientists from the German Cancer Research Center and Heidelberg University Hospital have now discovered.

23 Jan 2018

Powerful anti-oxidant can stop progression of fatty liver disease in young mice

As obesity continues to rise in the U.S., non-alcoholic fatty liver disease (NAFLD) has become a major public health issue, increasingly leading to cancer and liver transplants.

22 Jan 2018

Enzyme discovery provides new horizon of therapeutic opportunities across disease spectrum

Doctors have long treated heart attacks, improved asthma symptoms, and cured impotence by increasing levels of a single molecule in the body: nitric oxide.

19 Jan 2018

Performance enhancing benefits of caffeine more apparent for infrequent tea, coffee drinkers

A study led by sports scientists at Dublin City University has found that the performance enhancing benefits of caffeine are more apparent in athletes who do not drink caffeine-rich drinks such as tea, coffee, and energy drinks on a daily basis.

19 Jan 2018

EXD2 enzyme facilitates protein production in mitochondria

Researchers from the Genomic Instability and Cancer Laboratory at Institute for Research in Biomedicine (IRB Barcelona) have identified a key role for EXD2 in protein production in the mitochondria, the cellular organelles responsible for the majority of energy generation.

17 Jan 2018

Scientists describe groundbreaking training effect on the innate immune system

"Training" of precursors of white blood cells leads to a sustained positive response of the hematopoietic system. This effect could help accelerate the formation of new white blood cells, which are vitally needed during chemotherapy, a process that can slow down hematopoiesis.

15 Jan 2018

Scientists discover new enzyme that could help in the battle against obesity

Scientists have discovered a new enzyme in adipose tissue that helps regulate inflammation. The discovery could help in the battle against obesity.

15 Jan 2018

Scarring of fat tissue in obese people can make weight loss more difficult

The fat of obese people becomes distressed, scarred and inflamed, which can make weight loss more difficult, research at the University of Exeter has found.

12 Jan 2018

Exposure to estrogen-mimicking compounds may reverse effects of breast cancer treatment

Scientists from The Scripps Research Institute have discovered that two estrogen-mimicking compounds found in many foods appear to potently reverse the effects of palbociclib/letrozole, a popular drug combination for treating breast cancer.

12 Jan 2018

Genetic analysis can enhance outcomes of depression treatment

The failure of drugs such as SSRIs, used to treat depression, can be a result of genetic variations in patients.

12 Jan 2018

New study shows how the immune system regulates gut fungal population

Immune cells that process food and bacterial antigens in the intestines control the intestinal population of fungi, according to a new study from Weill Cornell Medicine scientists.

11 Jan 2018

Elevated levels of inflammation marker linked to lower muscle mass

Elevated levels of the inflammation marker CRP in the blood is an underlying cause of the loss of muscle mass in elderly persons, as shown by a new study from örebro University and University of Nottingham.

11 Jan 2018

Clinical study investigates lifestyle biomarkers in prostate cancer survivors

Advanced glycation end products, which have been linked to many chronic diseases, including diabetes, cardiovascular disease and cancer, build up in the body from birth due to normal metabolism but are often higher in those eating the high-fat, high-sugar, highly processed foods characteristic of the Western diet.

11 Jan 2018

Study identifies enzyme that regulates inflammation and metabolism in fat tissue

The human body has two primary kinds of fat--white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means of combating obesity.

11 Jan 2018

Study finds genetic variations linked to BMI and obesity risk

It's not just diet and physical activity; your genes also determine how easily you lose or gain weight. In a study published in the January issue of Nature Genetics, researchers at the Icahn School of Medicine at Mount Sinai and other institutions of the Genetic Investigation of Anthropometric Traits consortium found 13 genes that carry variations associated with body mass index.

10 Jan 2018