Metabolism News and Research

Latest Metabolism News and Research

New gene cut-and-paste methods help correct disease-causing mutation in animal model

For the first time, researchers have treated an animal model of a genetic disorder using a viral vector to deliver genome-editing components in which the disease- causing mutation has been corrected.

3 Feb 2016

Continuing weight loss from midlife predicts MCI risk

Increasing weight loss from middle age through the later stages of life may be an indicator of mild cognitive impairment, suggest study findings.

2 Feb 2016

Maternal diet during pregnancy and lactation leads to epigenetic changes in offspring

As the study shows, a high-fat diet during pregnancy and lactation leads to epigenetic changes in the offspring. These changes affect metabolic pathways regulated by the gut hormone GIP, whereby the adult offspring are more susceptible to obesity and insulin resistance, the precursor to type 2 diabetes. Similar mechanisms cannot be ruled out in humans, according to Pfeiffer.

2 Feb 2016

Irregular sleep schedules linked to adverse metabolic health in midlife women

A new study suggests that frequent shifts in sleep timing may be related to adverse metabolic health among non-shift working, midlife women.

1 Feb 2016

Study provides vital information about mechanisms governing DNA repair

DNA damage can lead to gene inactivation or deregulation and cause various diseases such as cancer; however, many DNA repair mechanisms allow cells to survive against such damage. A study lead by Antoine Simoneau of the laboratory of Dr. Hugo Wurtele, a researcher in immunology-oncology at the Maisonneuve-Rosemont Hospital (CIUSS de l'Est-de-l'Île-de-Montréal) and professor at the Faculty of Medicine, University of Montreal, and recently published in the prestigious journal Nucleic Acids Research, provides valuable information about certain mechanisms governing DNA repair.

31 Jan 2016

FDA-approved blood pressure drug reduces cell damage linked to Alzheimer's disease

In laboratory neuronal cultures, an FDA-approved drug used to treat high blood pressure reduced cell damage often linked to Alzheimer's disease, say researchers at Georgetown University Medical Center and the National Institutes of Health.

30 Jan 2016

New SBP research may lead to novel approach to treat heart failure

More than 5 million people in the United States suffer from heart failure, according to the American Heart Association. Less than half of those with heart failure live five years after diagnosis.

29 Jan 2016

CNIO team uses network theory to build and study first epigenetic communication network

One of the big questions for which there is still no clear answer in biology is how, based on the four universal letters that make up DNA, it is possible to generate such different organisms as a fly or a human, or the different organs and tissues they comprise. In recent years, researchers have discovered that the system is much more complicated than was originally thought.

29 Jan 2016

Research provides new molecular insight into heart failure

More than 5 million people in the United States suffer from heart failure, according to the American Heart Association. Less than half of those with heart failure live five years after diagnosis.

28 Jan 2016

UT Southwestern researchers reveal how CDK4/6-inhibitors alter pancreatic cancer cell metabolism

UT Southwestern Medical Center researchers have found that cancer drugs known as CDK4/6-inhibitors alter the metabolism of pancreatic cancer cells, revealing a biologic vulnerability that could be exploited for therapeutic gain.

22 Jan 2016

IDEAL study holds new hope for children exposed to methamphetamine in the womb

Despite continuing reports that methamphetamine abuse during pregnancy can lead to behavioral and emotional problems in children, pregnant women continue to abuse the illicit drug. Nearly one-fourth of pregnant women seeking treatment at federal facilities were methamphetamine users.

22 Jan 2016

Lilly receives FDA approval for Humulin R U-500 KwikPen

The U.S. Food and Drug Administration has approved Eli Lilly and Company's Humulin R U-500 KwikPen(insulin human injection) 500 units/mL, a pre-filled device containing Humulin R U-500, a highly concentrated formulation of insulin.

21 Jan 2016

Weekend junk food binges bad for your gut health

Yo-yoing between eating well during the week and bingeing on junk food over the weekend is likely to be just as bad for your gut health as a consistent diet of junk, new UNSW research suggests.

21 Jan 2016

New study shows 92% of measured restaurant meals exceed calorie requirements

Meals consumed at fast-food restaurants are often seen as one of the biggest contributors to the obesity epidemic. But according to a new study in the Journal of the American Academy of Nutrition and Dietetics, 92 percent of 364 measured restaurant meals from both large-chain and non-chain (local) restaurants exceeded recommended calorie requirements for a single meal.

20 Jan 2016

Study findings may help explain why risk of stroke changes after menopause

Risk of stroke in women may come down to a compound the body produces from estrogen known as 2-methoxyestradiol (2-ME). Furthermore, the compound's therapeutic potential may extend beyond treating stroke in women to healing brain injuries in men, a new study in American Journal of Physiology—Endocrinology and Metabolism reports.

20 Jan 2016

Immune killer cells use microptosis pathway to kill intracellular parasites

The immune system's killer cells deliver a tightly controlled, 3-phase knockout punch that kills intracellular parasites through a novel pathway that an international team led by researchers from the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital have named "microptosis."

20 Jan 2016

Simple blood test could help eliminate B12 deficiencies among older adults in long-term care homes

A high proportion of older adults entering long-term care homes in Ontario are B12 deficient, with more developing deficiencies over the course of their first year in residence, according to research from the University of Waterloo. There is a connection between B12 deficiency and several serious health conditions.

20 Jan 2016

Estrogen helps women fight flu virus better than men

Estrogen dramatically reduced the amount of flu virus that replicated in infected cells from women but not from men, a new study by researchers at the Johns Hopkins Bloomberg School of Public Health shows.

20 Jan 2016

Researchers identify protein that could protect against toxic degeneration of cells in ALS

J. Gavin Daigle, a PhD candidate at the LSU Health New Orleans School of Graduate Studies, is the first author of a paper whose findings reveal another piece of the Amyotrophic Lateral Sclerosis (ALS) puzzle.

19 Jan 2016

Phthalate DEHP could lead to weight gain

In cooperation with the Integrated Research and Treatment Center Adiposity Diseases at the University of Leipzig and the University Hospital Leipzig, researchers from the Helmholtz Centre for Environmental Research have now published a study in the PLOS ONE journal showing that the phthalate DEHP leads to weight gain and revealed the metabolic processes involved.

19 Jan 2016

Metabolism News and Research

Latest Metabolism News and Research

New gene cut-and-paste methods help correct disease-causing mutation in animal model

Continuing weight loss from midlife predicts MCI risk

Maternal diet during pregnancy and lactation leads to epigenetic changes in offspring

Irregular sleep schedules linked to adverse metabolic health in midlife women

Study provides vital information about mechanisms governing DNA repair

FDA-approved blood pressure drug reduces cell damage linked to Alzheimer's disease

New SBP research may lead to novel approach to treat heart failure

CNIO team uses network theory to build and study first epigenetic communication network

Research provides new molecular insight into heart failure

UT Southwestern researchers reveal how CDK4/6-inhibitors alter pancreatic cancer cell metabolism

IDEAL study holds new hope for children exposed to methamphetamine in the womb

Lilly receives FDA approval for Humulin R U-500 KwikPen

Weekend junk food binges bad for your gut health

New study shows 92% of measured restaurant meals exceed calorie requirements

Study findings may help explain why risk of stroke changes after menopause

Immune killer cells use microptosis pathway to kill intracellular parasites

Simple blood test could help eliminate B12 deficiencies among older adults in long-term care homes

Estrogen helps women fight flu virus better than men

Researchers identify protein that could protect against toxic degeneration of cells in ALS

Phthalate DEHP could lead to weight gain

Transforming Cardiovascular Care: Insights from Mina Makar at AstraZeneca

Clue's CEO Rhiannon White on the Future of Femtech and PCOS

Freezing Point Osmometry in Life Science Applications