Metabolism News and Research

Latest Metabolism News and Research

Intarcia Therapeutics announces positive top-line results from ITCA 650 Phase 3 FREEDOM-2 clinical trial

Intarcia Therapeutics, Inc. today announced positive top-line results from its 52-week Phase 3 FREEDOM-2 clinical trial to determine the comparative efficacy of the company's late-stage investigational candidate ITCA 650 to Merck's Januvia in reducing HbA1c in patients with type 2 diabetes following a year of treatment.

18 Aug 2015

Muscle mass appears to ward off bad cardiovascular effects of obesity

Even without losing fat, more muscle appears to go a long way in fighting off the bad cardiovascular effects of obesity. That emerging evidence has scientists looking hard for new targets to uncouple the unhealthy relationship between fat and cardiovascular disease.

18 Aug 2015

TKI outcomes ‘unfavourable’ in young CML patients

Adolescent and young adult patients with chronic myeloid leukaemia may have an unfavourable outcome on tyrosine kinase inhibitor therapy compared with their older counterparts, suggests a study of Japanese patients.

17 Aug 2015

FDA accepts Chiasma's NDA filing for octreotide capsules for treatment of adult patients with acromegaly

Chiasma, Inc., a U.S. late-stage biopharmaceutical company, today announced that the U.S. Food and Drug Administration has accepted for filing the Company's New Drug Application (NDA) for the marketing and sale of octreotide capsules, an oral drug proposed for the maintenance therapy of adult patients with acromegaly.

17 Aug 2015

TKI outcomes ‘unfavourable’ in young CML patients

14 Aug 2015

‘Medical foods’ for patients with rare IEMs may cause harm when not carefully managed

Many "medical foods" are designed to help manage patients with rare inborn errors of metabolism (IEMs), and can help prevent serious and life-threatening complications. However, such special foods may cause harm in some patients when their use is not carefully monitored and managed, according to a research team led by scientists at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health.

14 Aug 2015

Low-fat diets better than low-carb diets for weight loss, NIH study finds

In a recent study, restricting dietary fat led to body fat loss at a rate 68 percent higher than cutting the same number of carbohydrate calories when adults with obesity ate strictly controlled diets. Carb restriction lowered production of the fat-regulating hormone insulin and increased fat burning as expected, whereas fat restriction had no observed changes in insulin production or fat burning.

14 Aug 2015

Food ingredient formulators use different ways to enhance absorption, bioavailability of curcumin, turmeric

Few natural products have demonstrated the range of protective and therapeutic promise as have turmeric and its principal bioactive components, the curcuminoids.

13 Aug 2015

Gastric bypass surgery enhances energy expenditure

Gastric bypass surgery often leads to a sustained weight loss. Researchers at Sahlgrenska Academy have found part of the explanation: the operation enhances energy expenditure such that eating actually helps the person lose weight.

12 Aug 2015

TEAAM trial finds that testosterone has no effect on atherosclerosis progression

Testosterone sales have grown rapidly over the last decade, but few studies have examined the long-term effects of taking testosterone on cardiovascular health and other important outcomes. This week, investigators from Brigham and Women's Hospital report the results of the Testosterone's Effects on Atherosclerosis Progression in Aging Men (TEAAM) trial in the Journal of the American Medical Association.

12 Aug 2015

Gastric bypass surgery enhances energy expenditure, leads to sustained weight loss

11 Aug 2015

Sigma 1 receptor appears to play vital role in supporting the retina

A receptor that is already a target for treating neurodegenerative disease also appears to play a key role in supporting the retina, scientists report.

11 Aug 2015

Turing Pharmaceuticals acquires rights to market Daraprim (pyrimethamine) in the U.S.

Turing Pharmaceuticals AG today announced that it has acquired the exclusive rights to market Daraprim (pyrimethamine) in the U.S. from Impax Laboratories, Inc. The acquisition by Turing is part of a strategic effort focused on treatments for toxoplasmosis and other serious infectious diseases. The company also announced plans to invest in the development of new drug candidates for toxoplasmosis.

10 Aug 2015

Lexicon Pharmaceuticals' revenues decrease to $0.4 million in second quarter 2015

Lexicon Pharmaceuticals, Inc., today reported financial results for the second quarter ended June 30, 2015 and provided an overview of key milestones for the company's lead drug candidates.

7 Aug 2015

Scientists publish new important clues about marrow fat

While most of us worry about the fat cells building up on the fleshy parts of our bodies, scientists have started to pay serious attention to another kind of fat cell deep inside our bones, in what's called the marrow.

7 Aug 2015

BIDMC scientists discover new vitamin B3 pathway that regulates liver metabolism

Researchers at Beth Israel Deaconess Medical Center have identified a new vitamin B3 pathway that regulates liver metabolism. The discovery provides an opportunity to pursue the development of novel drug therapies to address obesity, type 2 diabetes and related metabolic diseases.

7 Aug 2015

TSRI study shows antioxidants slow aging process, reduce risk of infection

Scientists from the Florida campus of The Scripps Research Institute have shown how aging cripples the production of new immune cells, decreasing the immune system’s response to vaccines and putting the elderly at risk of infection.

7 Aug 2015

Inflammation from diets deficient in nutrients contribute to weight despite intake of macronutrients

If you are watching what you eat, working out, and still not seeing improvements in your cholesterol, blood pressure, blood sugar, etc., here's some hope. A new report appearing in the August 2015 issue of The FASEB Journal suggests that inflammation induced by deficiencies in vitamins and minerals might be the culprit.

6 Aug 2015

Metformin drug has impact on blood fat levels

Besides affecting the blood sugar levels, the substance Metformin, also has an impact on blood fat levels. This was elucidated by an interdisciplinary team of the German Center for Diabetes Research headed by Dr. Rui Wang-Sattler of the Helmholtz Zentrum München. Especially the harmful LDL cholesterol can be reduced.

6 Aug 2015

New research shows gastric bypass surgery lowers alcohol tolerance in women

Women who have gastric bypass surgery to lose weight should keep a close eye on their alcohol consumption, according to new research at Washington University School of Medicine in St. Louis.

6 Aug 2015

Metabolism News and Research

Latest Metabolism News and Research

Intarcia Therapeutics announces positive top-line results from ITCA 650 Phase 3 FREEDOM-2 clinical trial

Muscle mass appears to ward off bad cardiovascular effects of obesity

TKI outcomes ‘unfavourable’ in young CML patients

FDA accepts Chiasma's NDA filing for octreotide capsules for treatment of adult patients with acromegaly

TKI outcomes ‘unfavourable’ in young CML patients

‘Medical foods’ for patients with rare IEMs may cause harm when not carefully managed

Low-fat diets better than low-carb diets for weight loss, NIH study finds

Food ingredient formulators use different ways to enhance absorption, bioavailability of curcumin, turmeric

Gastric bypass surgery enhances energy expenditure

TEAAM trial finds that testosterone has no effect on atherosclerosis progression

Gastric bypass surgery enhances energy expenditure, leads to sustained weight loss

Sigma 1 receptor appears to play vital role in supporting the retina

Turing Pharmaceuticals acquires rights to market Daraprim (pyrimethamine) in the U.S.

Lexicon Pharmaceuticals' revenues decrease to $0.4 million in second quarter 2015

Scientists publish new important clues about marrow fat

BIDMC scientists discover new vitamin B3 pathway that regulates liver metabolism

TSRI study shows antioxidants slow aging process, reduce risk of infection

Inflammation from diets deficient in nutrients contribute to weight despite intake of macronutrients

Metformin drug has impact on blood fat levels

New research shows gastric bypass surgery lowers alcohol tolerance in women

Transforming Cardiovascular Care: Insights from Mina Makar at AstraZeneca

Clue's CEO Rhiannon White on the Future of Femtech and PCOS

Freezing Point Osmometry in Life Science Applications