Metabolism News and Research

Latest Metabolism News and Research

Tapentadol ER improves average intensity of chronic osteoarthritis knee pain: Study

Phase 3 safety and efficacy data comparing tapentadol extended release (ER) tablets, an investigational pain medication, to placebo in patients with moderate to severe chronic osteoarthritis knee pain have been published by Clinical Drug Investigation.

31 Aug 2010

New high throughput sequencing technology to identify genetic defects in rare diseases

The majority of rare diseases are hereditary. But despite significant progress in genome research, in most cases their exact cause remains unclear. The discovery of the underlying genetic defect is, however, a prerequisite for their definitive diagnosis and the development of innovative approaches to their treatment. Scientists at the Max Planck Institute for Molecular Genetics and the Institute of Medical Genetics at the Charit- Universit-tsmedizin - Berlin have succeeded in using a new process with which all of the genes in the human genome can be analysed simultaneously.

30 Aug 2010

Light signaling pathways, circadian rhythms affect biological functions: Research

A new study of the genetic basis of circadian rhythms - the biological responses related to daily light exposure - has found that a few minutes of light exposure in a fungus directly affects a huge range of its biological functions, everything from reproduction to coloring and DNA repair.

27 Aug 2010

Disulfiram drug effective in treating cocaine addiction: Research

Doctors have used the drug disulfiram to help patients stay sober for several decades. It interferes with the body's ability to metabolize alcohol, giving a fierce hangover to someone who consumes even a small amount of alcohol.More recently, disulfiram was shown to be effective in treating cocaine addiction as well, even though alcohol and cocaine affect the nervous system in different ways.

27 Aug 2010

New vibration technology to reduce stubborn stomach fat

For millions of dieters it seems impossible to lose belly fat no matter however carefully they watch what they eat or how many sit-ups they do. Some people give up and blame it on genetics, metabolism or body type and simply accept it as a fact of life. For whatever the reason, many Americans discover that stubborn fat around the stomach and love handles will not melt away despite their best efforts. Now a fitness research company says there is an effective way to win the battle of the bulge without special diets, drinks or difficult exercises.

27 Aug 2010

Naringenin from grape fruits initiates increased fatty acid oxidation, inhibits vLDL production

Naringenin, an antioxidant derived from the bitter flavor of grapefruits and other citrus fruits, may cause the liver to break down fat while increasing insulin sensitivity, a process that naturally occurs during long periods of fasting.

26 Aug 2010

Study examines correlation between point-of-care monitors, lactate flux during CEA procedure

CAS Medical Systems, Inc. today announced a new study to be published in the Canadian Journal of Anesthesia. The study from researchers in the Departments of Anesthesia and Surgery, at the University of Manitoba, Winnipeg, MB, Canada examined the correlation between a variety of point-of-care monitors and lactate flux, an indicator of metabolic stress during carotid endarterectomy.

25 Aug 2010

MRI and MR spectroscopy determine internal fat distribution: Study

Why is it that some people lose weight and body fat when they exercise and eat less and others don't. German researchers say MRI and magnetic resonance (MR) spectroscopy can provide the answer and help predict who will benefit from lifestyle changes.

25 Aug 2010

Mayo researchers develop new laboratory cell lines to study anaplastic thyroid cancer

To their deep dismay, researchers at Mayo Clinic discovered several years ago that laboratory samples of anaplastic thyroid cancer (ATC) they were using to help them find new treatments for this lethal disease were probably some other kind of cancer. It quickly became evident that the situation in their lab was common throughout the world. Up to half of the cell lines that were supposed to originate from patients with this rare thyroid cancer were either colon or melanoma cancer.

25 Aug 2010

Short period of excessive eating can have prolonged effects on health

A short period of excess food consumption can have long term effects on your body weight and fat storage even after the initial weight is lost. A study published in BioMed Central's open access journal Nutrition & Metabolism has found that a four-week episode of increased energy intake and decreased exercise can cause increased weight and fat mass more than two years later when compared to control individuals.

24 Aug 2010

Aileron Therapeutics, Roche partner to develop, commercialise Stapled Peptide Therapeutics

Aileron Therapeutics and Roche announced today that they have entered into a collaboration to discover, develop and commercialise a new class of drugs called Stapled Peptide Therapeutics. As part of this agreement, Roche will work with Aileron to develop drug candidates against up to five undisclosed targets selected from Roche's key therapeutic areas, which include oncology, virology, inflammation, metabolism and CNS.

24 Aug 2010

MIT symposium at ACS National Meeting to familiarize future scientists with unfamiliar public policy

With laws, government regulations, and funding priorities continuing to exert a broad impact on science, a group of graduate students at the Massachusetts Institute of Technology (MIT) is holding a special symposium Aug. 23 during the American Chemical Society (ACS) 240th National Meeting and Exhibition here to familiarize future scientists with the unfamiliar realm of public policy.

24 Aug 2010

Polyphenols affect nutrient absorption: Study

Health benefits from polyphenol antioxidants - substances found in many fruits and vegetables - may come at a cost to some people. Penn State nutritional scientists found that eating certain polyphenols decreased the amount of iron the body absorbs, which can increase the risk of developing an iron deficiency.

24 Aug 2010

SRI and Taiho collaborate to advance clinical development of TAS-108 breast cancer program

SRI International, an independent nonprofit research and development organization, announced today that it has assumed responsibility for further clinical development of the TAS-108 breast cancer program, in cooperation with Taiho Pharmaceuticals Co., Ltd., a leading Japanese pharmaceutical company. Further clinical development will focus on the lead compound's registration for the treatment of tamoxifen and aromatase inhibitor-resistant breast cancers.

20 Aug 2010

Prenatal pesticide exposure increases susceptibility to ADHD in children

Exposure to organophosphate (OP) pesticides before birth can increase susceptibility to attention disorders such as attention deficit/hyperactivity disorder (ADHD), according to new research published in the journal Environmental Health Perspectives (EHP). The new study is part of a growing body of research indicating that exposure to OP pesticides can adversely affect brain development.

19 Aug 2010

U-M research results show potential for discovering new avenues for anti-aging drugs

A team of University of Michigan scientists has found that suppressing a newly discovered gene lengthens the lifespan of roundworms. Scientists who study aging have long known that significantly restricting food intake makes animals live longer. But the goal is to find less drastic ways to achieve the same effect in humans someday. The U-M results offer promising early evidence that scientists may succeed at finding targets for drugs that someday could allow people to live longer, healthier lives.

19 Aug 2010

Study on differential aspects of cardiac insufficiency due to high blood pressure amongst women and men

Doctor Elena Zubillaga studied 109 women and 120 men admitted to hospital with a cardiac insufficiency solely due to high blood pressure. More concretely, she analysed the clinical, biochemical and ecocardiographical differences between the patients, depending on their sex. She also made reference to the data provided by serum markers for the metabolism of the collagen in the heart and the systolic function or contraction of the latter, as alterations taking place in the metabolism of myocardial collagen are associated with certain clinical situations.

18 Aug 2010

Xcelligence System provides real-time detection of neuronal cell death

Time course analyses of neuronal cell death and its underlying mechanisms require laborious experiments and multiple endpoint assays, often involving labelling with irritating compounds and cell disruption. A recent study used the xCELLigence System of Roche to investigate the response of the neuronal-like cell line HT-22 and cultured primary rat cortical neurons to different cell death stimuli and neuroprotectants.

18 Aug 2010

Genome-wide study identifies key genetic variant associated with nonalcoholic fatty liver disease

Researchers at Massachusetts General Hospital found that patients with nonalcoholic fatty liver disease (NAFLD) who carry an allele of the PNPLA3 gene have an increased risk of developing advanced disease, including nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. A second study supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) validates these findings and further concludes that in pediatric patients, the same allele is associated with earlier disease presentation.

18 Aug 2010

Research confirms genetic link to advanced fatty liver disease

17 Aug 2010

Metabolism News and Research

Latest Metabolism News and Research

Tapentadol ER improves average intensity of chronic osteoarthritis knee pain: Study

New high throughput sequencing technology to identify genetic defects in rare diseases

Light signaling pathways, circadian rhythms affect biological functions: Research

Disulfiram drug effective in treating cocaine addiction: Research

New vibration technology to reduce stubborn stomach fat

Naringenin from grape fruits initiates increased fatty acid oxidation, inhibits vLDL production

Study examines correlation between point-of-care monitors, lactate flux during CEA procedure

MRI and MR spectroscopy determine internal fat distribution: Study

Mayo researchers develop new laboratory cell lines to study anaplastic thyroid cancer

Short period of excessive eating can have prolonged effects on health

Aileron Therapeutics, Roche partner to develop, commercialise Stapled Peptide Therapeutics

MIT symposium at ACS National Meeting to familiarize future scientists with unfamiliar public policy

Polyphenols affect nutrient absorption: Study

SRI and Taiho collaborate to advance clinical development of TAS-108 breast cancer program

Prenatal pesticide exposure increases susceptibility to ADHD in children

U-M research results show potential for discovering new avenues for anti-aging drugs

Study on differential aspects of cardiac insufficiency due to high blood pressure amongst women and men

Xcelligence System provides real-time detection of neuronal cell death

Genome-wide study identifies key genetic variant associated with nonalcoholic fatty liver disease

Research confirms genetic link to advanced fatty liver disease

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