Nervous System News and Research

Latest Nervous System News and Research

High insulin levels increase inflammatory markers and beta-amyloids

Moderately elevated levels of insulin increase the levels of inflammatory markers and beta-amyloid in plasma and in cerebrospinal fluid, and these markers may contribute to Alzheimer's disease, according to a new study posted online today from Archives of Neurology, one of the JAMA/Archives journals.

9 Aug 2005

Findings do not support the hypothesis of increased risk of nontargeted infectious disease hospitalization after childhood vaccination

New research does not support a belief that children receiving multiple vaccines increase their risk of hospitalization for a nontargeted infectious disease, according to a study in the August 10 issue of JAMA: The Journal of the American Medical Association.

9 Aug 2005

Customized gene chip offers clues to prognosis in cases of neuroblastoma

Rather than covering the entire genome, the microarray focuses on suspect regions of chromosomes for signs of deleted genetic material known to play a role in the cancer.

2 Aug 2005

Customized gene chip will offer clues to prognosis in cases of neuroblastoma

Genetics researchers have developed a customized gene chip to rapidly scan tumor samples for specific DNA changes that offer clues to prognosis in cases of neuroblastoma, a common form of children's cancer.

2 Aug 2005

MediciNova starts phase II clinical trial of MN-166 for multiple sclerosis

MediciNova today announced the enrollment of patients in a Phase II clinical study with MN-166 for the treatment of multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. MN-166 is an orally administered drug with a novel mechanism of action that includes the inhibition of phosphodiesterase IV.

2 Aug 2005

Researchers reveal secret of key protein in brain and heart function

Brown University biologists have solved the structure of a critical piece of synapse-associated protein 97 (SAP97) found in abundance in the heart and head, where it is believed to play a role in everything from cardiac contractions to memory creation. Results are published in The Journal of Biological Chemistry.

31 Jul 2005

First trial of pramipexole for the treatment of fibromyalgia

The mechanism of fibromyalgia, a chronic illness characterized by muscle pain, fatigue, and sleep disturbances, is unknown and medications used to treat it (such as antidepressants, antiepileptics, muscle relaxants, antiinflammatories, sedative hypnotics, pain relievers and nutriceuticals) have had limited success.

28 Jul 2005

Percutaneous core-needle biopsy, provides samples of tissue suitable for accurate initial diagnosis of a solid tumor

Inserting biopsy needles through the skin appears to be a safe and reliable alternative to surgery for obtaining diagnostic samples of a suspected solid tumor in children, according to results of a study by investigators at St. Jude Children's Research Hospital.

25 Jul 2005

Spectrum Pharmaceuticals receives notice of a U.S. patent allowance for potential drug fo ADHD

Spectrum Pharmaceuticals has announced that it has received from the U.S. Patent and Trademark Office (USPTO) a Notice of Allowance for its patent application for SPI-339 entitled "Methods for Treating Cognitive/Attention Deficit Disorders Using Tetrahydroindolone Analogues and Derivatives."

21 Jul 2005

Older-style antidepressants, as well as anticonvulsant drugs, can help ease the disabling pain caused by nerve tissue damage

For many years antidepressants, which are believed to work by dampening pain signals, have been the first-line drugs for neuropathic pain. "It is usual to start with an antidepressant like amitriptyline, and if this fails then try an anticonvulsant," says Phil Wiffen, a researcher at Churchill Hospital in Oxford, England. "The results of these meta-analyses suggest this is probably still the best approach to take."

19 Jul 2005

Study warns against global use of old asthma medicines for kids' coughs

An asthma medicine widely used around the world to stop children's coughs has no provable benefit for that purpose and may cause harm, a new review of existing studies reports.

19 Jul 2005

Potential use of NH neurotransmitters as novel source for psychiatric drugs

Physiologists and medical researchers have long recognized the important endocrine roles played by the pituitary hormones oxytocin (OT) and vasopressin (VP) on peripheral systems in lactation, uterine contraction and urine concentration.

19 Jul 2005

Nerve cells can also release neurotransmitters outside of synapses

Every neurobiology textbook invariably states that nerve cells communicate with each other through synapses, the specialized cell-cell contacts found at the end of the cells' threadlike extensions. In the journal Science, researchers at the Salk Institute for Biological Sciences and the University of California at San Diego report that nerve cells, or neurons, may not have to rely on traditionally defined synapses to "talk" to each other.

18 Jul 2005

Single mutation in a human sodium channel gene can trigger pain in people with primary erythromelalgia

Yale School of Medicine researchers report the first demonstration that a single mutation in a human sodium channel gene can trigger pain in people with an inherited pain syndrome known as primary erythromelalgia, according to a study published this month in the journal Brain.

13 Jul 2005

Transplanted neural stem cells may serve not only as replacement cells for tissue repair, but in some circumstances may also protect the brain from inflammation

Researchers at the San Raffaele Hospital (Milan, Italy) published unexpected results of studies in which immature nerve cells (adult mouse neural stem cells) injected into the blood of mice with MS-like disease were able to suppress the immune attacks that damage the brain and spinal cord tissues.

13 Jul 2005

"Ipod-like" device to help correct balance disorders

Researchers at Oregon Health & Science University's Neurological Sciences Institute and the University of Bologna have developed a portable "Ipod-like" device that can be used to help correct balance disorders. Scientists believe this new device, based on auditory feedback of balance, can be worn on the belt like a pager to provide regular therapy for patients with balance disorders, improving their day-to-day activities.

13 Jul 2005

Congenital central hypoventilation syndrome (CCHS) offers clues to SIDS, sleep apnea

Imagine raising a child who stops breathing when falling asleep - and has to be reminded to visit the bathroom after drinking a Big Gulp. That's the dilemma faced by parents of children born with congenital central hypoventilation syndrome (CCHS).

11 Jul 2005

Research explains one of the fundamental mysteries of multiple sclerosis

Scientists have pinpointed a chemical messenger that frees some white blood cells from the body's normal constraints, allowing the cells to act like renegades that could damage nerves in the central nervous system. The work, to be published in the July 15 issue of the Journal of Immunology and just published on-line, helps explain one of the fundamental mysteries of multiple sclerosis (MS).

11 Jul 2005

New roles for granulocyte colony-stimulating factor (G-CSF) in treating stroke

In a study appearing online on July 7 in advance of print publication of the August 1 issue of the Journal of Clinical Investigation, Armin Schneider and colleagues from Axaron Biosciences describe new roles for granulocyte colony-stimulating factor (G-CSF) in treating stroke and other central nervous system roles of this protein.

11 Jul 2005

Prescription drug abuse in the USA exceeds 15 million

A recently released report by the National Center on Addiction and Substance Abuse at Columbia University suggests between 1992 and 2003, more Americans were abusing controlled prescription drugs than cocaine, hallucinogens, inhalants and heroin put together.

11 Jul 2005