Neurofibromatosis News and Research

Latest Neurofibromatosis News and Research

Transposons create genomic instability and are implicated in cancer and other diseases: Research

Transposons, or "jumping genes," make up roughly half of the human genome. Geneticists previously estimated that they replicate and insert themselves into new locations roughly one in every 20 live births.

28 Jun 2010

Jumping elements in primates may have important consequences for studies of human genetic diseases

The density of transposable (jumping) elements between sex chromosomes in primates may have important consequences for the studies of human genetic diseases, say Penn State University researchers.

30 Apr 2010

Neuroscientists prevent memory loss in fruit flies by blocking activity of PI3 kinase signaling protein

By blocking the cellular signaling activity of a protein, a team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has prevented memory loss in fruit flies caused by brain plaques similar to those thought to cause Alzheimer's disease in humans. The study also resolves a long-standing controversy about the role of this protein, PI3 kinase, which was previously thought to have a protective function against the disease.

30 Mar 2010

Children with neurofibromatosis more likely to have cardiovascular problems

Researchers have discovered how a genetic disease known mainly for its life-threatening tumors also can cause sudden death from cardiovascular disease in children, and are mounting a clinical trial to develop treatments for the problem.

24 Mar 2010

Auditory brainstem implants for adults with damaged cochlear nerves

If a siren sounded but you were deaf, might you still be able to hear the sound?

23 Mar 2010

Key mechanism that makes brain cells become tumorous identified

Researchers from the Peninsula Medical School in Plymouth (UK), the Memorial Sloan-Kettering Cancer Center in New York, Cornell University in New York, Weil Medical College in New York and the Center for Neural Tumour Research in Los Angeles, have for the first time identified a key mechanism that makes certain cells become tumorous in the brain. The resulting tumours occur most often spontaneously but can also occur in numbers as part of the inherited disease Neurofibromatosis type 2.

23 Feb 2010

Head and neck tumors in close proximity to sensitive areas may lead to brain injury, visionary risk or hearing loss

When head and neck tumors - from sinus tumors to acoustic neuromas attached to the hearing and balance nerve at the base of the skull - are located in close proximity to such sensitive areas such as the brain and eyes, they are particularly dangerous due to possible brain injury, visionary risk or hearing loss.

23 Feb 2010

Study may pave way for more refined treatments for brain tumors

Researchers at Washington University School of Medicine in St. Louis have shown once again that "ready, fire, aim," nonsensical though it may sound, can be an essential approach to research.

10 Feb 2010

UT Southwestern Medical Center performs minimally invasive procedures for sinuses and chronic rhinosinusitis

Only about one in 2,000 people in the United States get a sinus tumor, but Johnnie Wilcox was one of the unfortunate few.

15 Dec 2009

Diagnosing patients with syndrome similar to neurofibromatosis type 1 may be difficult

An analysis of patients with a syndrome similar to the genetic disorder, neurofibromatosis type 1, indicates that diagnosis may be difficult because of shared clinical findings, such as certain pigmentary characteristics, according to a study in the November 18 issue of JAMA.

19 Nov 2009

Decreased expression of tumor suppressor gene PTEN transforms neurofibromas into cancer

Researchers at UCLA's Jonsson Comprehensive Cancer Center showed for the first time that the loss or decreased expression of the tumor suppressor gene PTEN plays a central role in the malignant transformation of benign nerve tumors called neurofibromas into a malignant and extremely deadly form of sarcoma.

14 Oct 2009

Plexxikon commences patient dosing in PLX3397 Phase 1 clinical trial

Plexxikon Inc. today announced that dosing of cancer patients with PLX3397 has started in a Phase 1 clinical trial. PLX3397 is a novel, oral investigational drug for treating multiple diseases, including metastatic cancer and rheumatoid arthritis.

9 Oct 2009

NIH awards $2 million grant to fight Neurofibromatosis type 2 disease

University of Central Florida Associate Professor Cristina Fernandez-Valle just landed two federal grants worth $2 million to research a disease that can leave children and young adults deaf, partially paralyzed or brain damaged.

6 Oct 2009

UltraPulse SurgiTouch CO2 laser for the treatment of airway stenosis

Lumenis Ltd., the world's largest medical laser company, announced today that it supplied an UltraPulse SurgiTouch CO2 laser with Digital AcuBlade microsurgery system to the Landspitalinn University Hospital in Reykjavik, Iceland. Lumenis' state of the art laser system, was used by Dr. Paul Castellanos to perform Trans-oral Laser Microsurgery (TLM) for the treatment of airway stenosis with obstructing neurofibromatosis of the laryngopharynx on a 9-year-old girl and four other patients.

From Lumenis Inc. 21 Sep 2009

Small molecule inhibitors could create new combination therapies

Scientists at Fox Chase Cancer Center have discovered a unique method of attack that may be used to inhibit signaling enzymes called kinases, which often have a role in sustaining drug-resistant cancerous cells. They have confirmed that IPA-3, a small molecular inhibitor of a kinase called PAK1, targets the enzyme's regulatory domain, mimicking how enzymes are naturally regulated within cells.

8 Sep 2009

New approach for understanding how drug resistance occurs in leukemia

UCSF researchers have developed a new approach to identify specific genes that influence how cancer cells respond to drugs and how they become resistant. This strategy, which involves producing diverse genetic mutations that result in leukemia and associating specific mutations with treatment outcomes, will enable researchers to better understand how drug resistance occurs in leukemia and other cancers, and has important long-term implications for the development of more effective therapies.

5 Sep 2009

Light Sciences Oncology announces Phase 2 trial of Aptocine in Benign Prostatic Hyperplasia

Light Sciences Oncology, Inc. (LSO) today announced the treatment of the first patients in a Phase 2 clinical trial of its innovative targeted drug treatment Aptocine(TM) (talaporfin sodium) in Benign Prostatic Hyperplasia (BPH). The Phase 2 trial expands the Aptocine BPH development program on the basis of a Phase 1 study at escalating light doses. In the open-label Phase 2 trial, Aptocine is being tested for safety and efficacy in 40 patients with lower urinary tract symptoms (LUTS) due to BPH. Aptocine is also in two Phase 3 clinical trials for solid tumors in the liver as well as preclinical development for prostate cancer.

19 Aug 2009

Secretary Sebelius announces Senate confirmation of Dr. Francis Collins as Director of NIH

HHS Secretary Kathleen Sebelius announced today that the United States Senate unanimously confirmed Dr. Francis Collins as the next Director of the National Institutes of Health.

10 Aug 2009

Physicians perform rare surgery to restore hearing to a deaf patient

Marisela Leon, 44, has neurofibromatosis type 2 -- a rare genetic condition that causes tumors to grow on nerves in the brain or spinal cord, but most commonly on the auditory nerve. Leon lost her hearing more than four years ago when surgery to remove a tumor damaged her auditory nerve.

22 Dec 2008

Promising clinical trial for Progeria "premature aging" disease

One of the fastest translations of a basic research discovery into a promising clinical trial for an "untreatable" and fatal disorder will be discussed publicly for the first time by the key players in this remarkable research story, on Sunday, Dec. 14, at the American Society for Cell Biology (ASCB)'s annual meeting in San Francisco.

14 Dec 2008

Neurofibromatosis News and Research

Latest Neurofibromatosis News and Research

Transposons create genomic instability and are implicated in cancer and other diseases: Research

Jumping elements in primates may have important consequences for studies of human genetic diseases

Neuroscientists prevent memory loss in fruit flies by blocking activity of PI3 kinase signaling protein

Children with neurofibromatosis more likely to have cardiovascular problems

Auditory brainstem implants for adults with damaged cochlear nerves

Key mechanism that makes brain cells become tumorous identified

Head and neck tumors in close proximity to sensitive areas may lead to brain injury, visionary risk or hearing loss

Study may pave way for more refined treatments for brain tumors

UT Southwestern Medical Center performs minimally invasive procedures for sinuses and chronic rhinosinusitis

Diagnosing patients with syndrome similar to neurofibromatosis type 1 may be difficult

Decreased expression of tumor suppressor gene PTEN transforms neurofibromas into cancer

Plexxikon commences patient dosing in PLX3397 Phase 1 clinical trial

NIH awards $2 million grant to fight Neurofibromatosis type 2 disease

UltraPulse SurgiTouch CO2 laser for the treatment of airway stenosis

Small molecule inhibitors could create new combination therapies

New approach for understanding how drug resistance occurs in leukemia

Light Sciences Oncology announces Phase 2 trial of Aptocine in Benign Prostatic Hyperplasia

Secretary Sebelius announces Senate confirmation of Dr. Francis Collins as Director of NIH

Physicians perform rare surgery to restore hearing to a deaf patient

Promising clinical trial for Progeria "premature aging" disease

Neuroscience - Third Edition eBook

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Neurofibromatosis News and Research

Latest Neurofibromatosis News and Research

Neuroscience - Third Edition eBook

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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