Pharmacology News and Research

Latest Pharmacology News and Research

Histones steadily replaced in brain cells throughout life, find Mount Sinai researchers

For decades, researchers in the genetics field have theorized that the protein spools around which DNA is wound, histones, remain constant in the brain, never changing after development in the womb.

2 Jul 2015

Concert Pharmaceuticals’ precision deuteration platform can enhance metabolic properties of drugs

Substituting deuterium for certain hydrogen atoms in molecules has been shown to enhance the metabolic properties of a number of drugs and provides a promising approach to the discovery and development of innovative drug products.

2 Jul 2015

Sialic acid may play significant role in certain brain disorders

A new report published in the July 2015 issue of The FASEB Journal suggests that a common molecule found in higher animals, including humans, affects brain structure. This molecule may play a significant role in how brain cells communicate, possibly shedding light on the underlying causes of certain brain disorders.

1 Jul 2015

Researchers map physical properties of live breast cancer cells using advanced AFM technology

Researchers who developed a high-speed form of atomic force microscopy have shown how to image the physical properties of live breast cancer cells, for the first time revealing details about how deactivation of a key protein may lead to metastasis.

30 Jun 2015

University of Cambridge, AstraZeneca announce new joint schemes to support PhD scholarships, clinical lectureships

AstraZeneca and the University of Cambridge today announced three new joint schemes to support more than 80 PhD scholarshipsand eight clinical lectureships over the next five years spanning translational science, basic and clinical research.

30 Jun 2015

Spinifex Pharmaceuticals enters into agreement to be acquired by Novartis

Spinifex Pharmaceuticals, Inc., a company focused on the development of new drugs for the treatment of chronic pain, today announces that it has agreed to the sale of Spinifex to Novartis International AG, for an upfront cash consideration of US$200 million plus undisclosed clinical development and regulatory milestone payments.

29 Jun 2015

Discovery sheds light on how the Hippo pathway maintains cellular balance

Researchers at University of California, San Diego School of Medicine have discovered a self-regulating loop in the Hippo pathway, a signaling channel garnering increased attention from cancer researchers due to its role in controlling organ size, cell proliferation and cell death.

27 Jun 2015

SLU researchers find way to stop growth of cancer cells by targeting the Warburg Effect

In research published in Cancer Cell, Thomas Burris, Ph.D., chair of pharmacology and physiology at Saint Louis University, has, for the first time, found a way to stop cancer cell growth by targeting the Warburg Effect, a trait of cancer cell metabolism that scientists have been eager to exploit.

26 Jun 2015

Scientists develop small molecule drug that prevents autophagy from starting in cancer cells

As a tumor grows, its cancerous cells ramp up an energy-harvesting process to support its hasty development. This process, called autophagy, is normally used by a cell to recycle damaged organelles and proteins, but is also co-opted by cancer cells to meet their increased energy and metabolic demands.

26 Jun 2015

E2F4 biomarker can help predict prognosis and response to BCG therapy in bladder cancer

Investigators from Dartmouth's Norris Cotton Cancer Center harnessed genomic data to discover that the previously identified E2F4 signature in breast cancer can be utilized to predict prognosis and response to therapy in bladder cancer.

25 Jun 2015

UIC researchers identify molecular mechanism that directs embryonic stem cells to turn into endothelial cells

Researchers at the University of Illinois at Chicago have identified a molecular mechanism that directs embryonic stem cells to mature into endothelial cells -- the specialized cells that form blood vessels. Understanding the processes initiated by this mechanism could help scientists more efficiently convert stem cells into endothelial cells for use in tissue repair, or for engineering blood vessels to bypass blockages in the heart.

25 Jun 2015

Purdue University-led study could lead to better treatments for people infected with MERS virus

A Purdue University-led team of researchers studying the Middle East Respiratory Syndrome, or MERS, have found molecules that shut down the activity of an essential enzyme in the virus and could lead the way to better treatments for those infected.

23 Jun 2015

Researchers explore the science of exosomes in heart repair

A little more than a decade ago, researchers discovered that all cells secrete tiny communications modules jammed with an entire work crew of messages for other cells. Today, a team of researchers, led by stem cell researcher Raj Kishore, PhD, Director of the Stem Cell Therapy Program at the Center for Translational Medicine at Temple University School of Medicine, is harnessing the communications vesicles excreted by stem cells and using them to induce the damaged heart to repair itself.

19 Jun 2015

UB study sheds light on the molecular basis of cocaine addiction

Researchers at the University at Buffalo have discovered a previously unknown neural pathway that can regulate changes made in the brain due to cocaine use, providing new insight into the molecular basis of cocaine addiction.

19 Jun 2015

Montefiore dermatologist debunks myths regarding skin care, offers information to help people enjoy summer days

As many begin to spend long summer days outside, it's crucial to have the right information about skin protection and the dangers of sun exposure. Today, Montefiore dermatologist Dr. Holly Kanavy debunks many widely-shared myths regarding skin care and offers accurate information to help people enjoy the outdoors this summer while preserving their skin.

18 Jun 2015

PAREXEL expands Perceptive MyTrials Data-Driven Monitoring solution

PAREXEL International Corporation, a leading global biopharmaceutical services provider, today launched next generation risk-based monitoring capabilities, expanding its Perceptive MyTrials Data-Driven Monitoring (DDM) solution.

From Parexel 18 Jun 2015

AMRI, PerkinElmer form strategic collaboration to accelerate drug discovery

As further evidence of Governor Andrew M. Cuomo's successful establishment of a dynamic and growing bio-pharma sector in Buffalo, New York, Albany Molecular Research Inc. and PerkinElmer, Inc. today announced the formation of a strategic collaboration in connection with the opening of AMRI's drug discovery center as part of the new Buffalo Medical Innovation and Commercialization Hub.

17 Jun 2015

Rapamycin drug reduces obesity, preserves lean body mass in older rats

Aging can cause many changes to the body, including obesity and a loss of lean mass. Now, a group of University of Florida Health researchers has discovered that an existing drug reduces body fat and appetite in older rats, which has intriguing implications for aging humans.

17 Jun 2015

Mutations in ZnT2 protein reduce amounts of zinc levels in mother's milk

Zinc plays an important role in a woman's ability to successfully breast-feed her child, according to health researchers.

16 Jun 2015

Clinical studies confirm safety, efficacy of opicapone in Parkinson’s disease patients

BIAL is presenting 11 research posters at the 19th International Congress of Parkinson's Disease and Movement Disorders (June 14–15, San Diego, CA). These evaluate the safety and efficacy of opicapone (BIA 9-1067), a novel once-daily catechol-O-methyltransferase (COMT) inhibitor for use as adjunctive therapy in levodopa-treated Parkinson’s disease patients with end of dose motor fluctuations.

15 Jun 2015

Pharmacology News and Research

Latest Pharmacology News and Research

Histones steadily replaced in brain cells throughout life, find Mount Sinai researchers

Concert Pharmaceuticals’ precision deuteration platform can enhance metabolic properties of drugs

Sialic acid may play significant role in certain brain disorders

Researchers map physical properties of live breast cancer cells using advanced AFM technology

University of Cambridge, AstraZeneca announce new joint schemes to support PhD scholarships, clinical lectureships

Spinifex Pharmaceuticals enters into agreement to be acquired by Novartis

Discovery sheds light on how the Hippo pathway maintains cellular balance

SLU researchers find way to stop growth of cancer cells by targeting the Warburg Effect

Scientists develop small molecule drug that prevents autophagy from starting in cancer cells

E2F4 biomarker can help predict prognosis and response to BCG therapy in bladder cancer

UIC researchers identify molecular mechanism that directs embryonic stem cells to turn into endothelial cells

Purdue University-led study could lead to better treatments for people infected with MERS virus

Researchers explore the science of exosomes in heart repair

UB study sheds light on the molecular basis of cocaine addiction

Montefiore dermatologist debunks myths regarding skin care, offers information to help people enjoy summer days

PAREXEL expands Perceptive MyTrials Data-Driven Monitoring solution

AMRI, PerkinElmer form strategic collaboration to accelerate drug discovery

Rapamycin drug reduces obesity, preserves lean body mass in older rats

Mutations in ZnT2 protein reduce amounts of zinc levels in mother's milk

Clinical studies confirm safety, efficacy of opicapone in Parkinson’s disease patients

Pittcon Highlights: Pharmaceutical & Biologic eBook

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Pharmacology News and Research

Latest Pharmacology News and Research

Pittcon Highlights: Pharmaceutical & Biologic eBook

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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