Pharmacology News and Research

Latest Pharmacology News and Research

Researchers reveal how melanoma develops resistance to Zelboraf

Cancer is tough to kill and has many ways of evading the drugs used by oncologists to try and eliminate it. Now, researchers at UCLA's Jonsson Comprehensive Cancer Center have uncovered how an advanced form of melanoma gets around an inhibitor, Zelboraf, which targets the mutated BRAF gene.

7 Mar 2012

Scientists to investigate biochemical switch: P2X1 receptor

Scientists investigating a 'biochemical switch' linked to strokes and heart disease claim to have made an advance in understanding how it is 'turned on'.

6 Mar 2012

Arrowhead, Axolabs enter into RNAi therapeutics strategic agreement

Arrowhead Research Corporation, a nanomedicine company with development programs in RNAi therapeutics and obesity, and Axolabs GmbH, a custom research organization offering preclinical solutions and consultancy in the field of oligonucleotide therapeutics, today announced that they have entered into a Strategic Alliance and Master Services Agreement.

5 Mar 2012

Researchers confirm how food poisoning bacteria hijack cell's sense of direction

Working in the emerging field of systems biology, UT Southwestern Medical Center researchers mathematically predicted how bacteria that cause food poisoning hijack a cell's sense of direction and then confirmed those predictions in living cells.

2 Mar 2012

F-DOPA PET/CT imaging alters management plans for patients with brain cancer

Imaging amino acid transporters with positron emission tomography/computed tomography (PET/CT) has been shown to significantly alter intended management plans for patients with brain tumors, according to research in the March issue of The Journal of Nuclear Medicine.

2 Mar 2012

Conference on follow-on versions of complex drugs

On March 9, the New York Academy of Sciences will present "Scientific Considerations for Complex Drugs in Light of Established Regulatory Guidance." This full-day conference will explore current definitions, global scientific and regulatory hurdles, and future challenges for follow-on versions of complex drugs.

2 Mar 2012

Induced hyperammonaemia increases daytime sleepiness in patients with cirrhosis

Italian and Swiss researchers confirm that induced hyperammonaemia significantly increases daytime sleepiness in patients with cirrhosis. The findings available in the March issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases, show that higher blood levels of ammonia reduced the ability of cirrhotic patients to produce restorative sleep.

2 Mar 2012

Patients worried about statin use after label warnings from FDA

The U.S. Food and Drug Administration's announcement Tuesday stated that it would require additional safety warnings on the labels of the cholesterol-lowering drugs. Doctors have said that while the benefits of statins outweigh their potential harm, some patients are alarmed by the new announcement.

1 Mar 2012

IOM report identifies options that could further improve information obtained from pediatric studies

Federal laws that motivate or require drug and biologic developers to conduct pediatric studies have yielded beneficial information to guide the use of medications in children, says a new report by the Institute of Medicine. Still, studies involving children continue to be limited, especially in certain areas such as medications' use in newborns and long-term safety and effectiveness in children.

1 Mar 2012

'Call to action' on wrong-route injections in anesthesia

Worldwide changes in catheter system design are urgently needed to prevent serious complications caused by accidental injection of drugs into the wrong location, according to a special editoral in the March issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

1 Mar 2012

Cyclotides discovery may open up new possibilities for immune suppression

A team of researchers at the MedUni Vienna, together with scientists from the University Hospital of Freiburg, has decoded a mechanism in cyclic plant peptides, known as cyclotides, from the family of coffee plants (Rubiaceae) that could open up new possibilities for immune suppression.

1 Mar 2012

Loss of STAT1 transcription factor causes breast cancer development

Breast cancer represents about a fifth of all cancers diagnosed in women. The reasons for the rapid progression of the disease remain relatively poorly understood but recent work in the group of Veronika Sexl at the University of Veterinary Medicine, Vienna has pointed the finger strongly at loss or inactivation of the transcription factor STAT1.

1 Mar 2012

More than 80% of anesthesiologists have been involved in surgical catastrophes

More than 80 percent of anesthesiologists have been involved in a catastrophic event involving death or injury to a patient during surgery, suggests a survey study in the March issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society.

1 Mar 2012

Springer adds 6 new quarterly clinical review journals to medicine portfolio

Springer is adding six new quarterly clinical review journals to its existing medicine portfolio in March 2012. These new journals will expand the publisher's medical specialty coverage, focusing on dermatology, geriatrics/gerontology, nutrition, obesity, obstetrics/gynecology and respiratory care.

29 Feb 2012

Ipsen total revenues increase 5.5% to €1,234.9M for the full year 2011

The Board of Directors of Ipsen, chaired by Marc de Garidel, met on 28 February 2012 to review the Group's results for 2011, published today.

29 Feb 2012

KCC's geriatric oncology symposium to take place on March 9

Approaches to treating elderly cancer patients are evolving as more of the population ages and the need for specialized care becomes more evident. To address these issues and others, national thought leaders in geriatric oncology will gather at a unique symposium at the Kimmel Cancer Center at Jefferson (KCC) in Philadelphia on Friday, March 9, 2012, where they will present an overview of the latest advances in the understanding and treatment of cancer in older adults in an effort to impact patient care.

29 Feb 2012

UT Southwestern's chairman of pharmacology wins 2012 Rolf Luft Award

Dr. David Mangelsdorf, chairman of pharmacology at UT Southwestern Medical Center, has been awarded the 2012 Rolf Luft Award for research that has advanced understanding of nuclear receptor pathways.

28 Feb 2012

People with depression have increased connections among most brain areas

Most of us know what it means when it's said that someone is depressed. But commonly, true clinical depression brings with it a number of other symptoms. These can include anxiety, poor attention and concentration, memory issues, and sleep disturbances.

27 Feb 2012

Translational research in addiction conference to take place in Texas

Young people starting out in addiction research will get a turbo-boost to their careers March 3-4 at an annual conference that puts them face to face with internationally recognized addiction researchers and clinicians.

27 Feb 2012

Rosemary aroma may improve cognitive performance

Hailed since ancient times for its medicinal properties, we still have a lot to learn about the effects of rosemary. Now researchers writing in Therapeutic Advances in Psychopharmacology, published by SAGE, have shown for the first time that blood levels of a rosemary oil component correlate with improved cognitive performance.

26 Feb 2012