Pharmacology News and Research

Latest Pharmacology News and Research

GRB7 gene drives an aggressive form of breast cancer, researchers find

Oregon Health & Science University Knight Cancer Institute researchers found that the GRB7 gene drives an aggressive form of breast cancer and acts independently of the HER-2 gene, known to be a stimulator of breast cancer growth. Isolating the role of this gene could ultimately help fine-tune a patient's treatment and enable physicians to provide a more accurate prognosis.

23 Jul 2010

Protein parkin essential for hypothalamic neurons recovery in Parkinson's disease patients

A Michigan State University researcher is working to uncover how a protein known as parkin may help nerve cells fight off damage from Parkinson's disease, a strategy that could lead to new therapies for the degenerative ailment.

23 Jul 2010

New research identifies stem cells that generate three critical classes of nerve cells

New research, published in the journal Development, by Dr. Anthony-Samuel LaMantia, professor of Pharmacology & Physiology and director of the newly formed GW Institute for Neuroscience, and his colleagues have identified the stem cells that generate three critical classes of nerve cells - olfactory receptors, vomeronasal and gonadotropin releasing hormone neurons - that are responsible for enabling animals and humans, to eat, interact socially and reproduce.

22 Jul 2010

Gladstone Institutes, H. Lundbeck collaborate to identify therapeutic candidates for neurological diseases

The Gladstone Institutes and the international pharmaceutical company H. Lundbeck A/S have announced a collaborative research agreement to study and identify therapeutic candidates for neurological diseases. The agreement funds research at the Gladstone Center for Translational Research led by Gladstone investigator Katerina Akassoglou, PhD, and establishes the new Lundbeck Center for Neurovascular and Immuno-imaging at the Gladstone Institute of Neurological Disease.

22 Jul 2010

Five new large pharma clients place initial studies with LAB Research

LAB Research Inc., a Canadian-based global non-clinical contract research organization, today announced that five new large pharma clients have placed initial studies with the Company following the successful pre-qualification of its sites. These new clients are expected to represent at least 5-10% of the Company's revenues by 2011.

21 Jul 2010

Major turning point in antiepileptic drug testing, development

New York University researchers revealed that data from previously completed withdrawal to monotherapy studies for antiepileptic drugs provide a valid control for future studies, obviating the need for placebo/pseudo-placebo trials to demonstrate the efficacy of these drugs as monotherapy. Results of this study are now available online in Epilepsia, a journal published by Wiley-Blackwell on behalf of the International League Against Epilepsy.

21 Jul 2010

Researchers reveal findings on restricted lineage of iPS cells

Adult cells that have been reprogrammed into induced pluripotent stem cells (iPS cells) do not completely let go of their past, perhaps limiting their ability to function as a less controversial alternative to embryonic stem cells for basic research and cell replacement therapies, according to researchers at Children's Hospital Boston, John Hopkins University and their colleagues

20 Jul 2010

Cellectis bioresearch introduces new technology to develop cell-based assays for HTS studies

Cellectis bioresearch, a specialist in genome customization and a subsidiary of Cellectis, today announced the publication of a scientific study describing a novel method, based on meganuclease-driven targeted integration, for the generation of stable cell lines compatible with high throughput screening (HTS).The study demonstrated Cellectis bioresearch's technology to be faster, more reliable and efficient in deriving cell-based assays for HTS studies than classical methods.

20 Jul 2010

ZIOPHARM Oncology commences palifosfamide Phase III clinical trial for metastatic soft tissue sarcoma

ZIOPHARM Oncology, Inc. today announced the initiation of the pivotal Phase III clinical trial for palifosfamide in patients with front-line metastatic soft tissue sarcoma. The study, called PICASSO 3, is an international, randomized, double-blinded, placebo-controlled trial designed to enroll approximately 424 patients with metastatic soft tissue sarcoma who have never been treated with chemotherapy for metastatic disease.

20 Jul 2010

Researchers identify a mechanism that explains different phases of CML progression

Researchers at Duke University Medical Center have identified a mechanism that could explain how patients move into the worst phase of chronic myelogenous leukemia.

20 Jul 2010

Researchers to receive $1.2M from Susan G. Komen for the Cure for breast cancer research

Four researchers from Detroit, Michigan's Barbara Ann Karmanos Cancer Institute and Wayne State University will receive a total of $1.2 million from Susan G. Komen for the Cure to help advance research to better detect, prevent and eliminate breast cancer. The $1.2 million awarded to these outstanding scientists is part of the $59 million portfolio of research grants that Susan G. Komen for the Cure has awarded this year alone to scientists across the globe to help accelerate innovative breast cancer research.

17 Jul 2010

ICON opens purpose-built clinical pharmacology unit within CMFT campus

ICON plc,, a global provider of outsourced development services to the pharmaceutical, biotechnology and medical device industries, today announced the official opening of a purpose-built clinical pharmacology unit within the Central Manchester University Hospitals Foundation Trust (CMFT) campus in Manchester, UK. Initial studies in the unit utilising translational medicine methodologies to expedite drug development projects began in June, and already 110 volunteers have participated in studies there.

17 Jul 2010

ArmaGen uses BBB molecular Trojan horse platform technology to create brain penetrating form of human EPO

Human erythropoietin (EPO) is a potent neuroprotective agent for multiple brain disorders, including stroke, brain and spinal cord injury, and Parkinson's disease. However, EPO drug development for the brain is limited, because EPO does not cross the blood-brain barrier (BBB). In acute stroke or brain injury, the BBB is intact in the early hours after the insult when neuroprotection is still possible. Therefore, large molecule biopharmaceuticals such as EPO must be re-engineered to enable BBB transport.

17 Jul 2010

Study reveals anti-diabetic properties of cashew seed extract

Cashew seed extract shows promise as an effective anti-diabetic, according to a new study from the University of Montreal (Canada) and the Universit- de Yaound- (Cameroun). Published in the journal Molecular Nutrition & Food Research, the investigation analyzed the reputed health benefits of cashew tree products on diabetes, notably whether cashew extracts could improve the body's response to its own insulin.

15 Jul 2010

NIH awards $38.2M grant to Georgetown-Howard Universities Center for Clinical and Translational Science

In support of a critical partnership between Georgetown University Medical Center and Howard University, the National Institutes of Health (NIH) has awarded a $38.2 million Clinical and Translational Sciences Award to aid the universities' effort to transform health care and preventive practices in communities through medical discoveries made in laboratories and clinical settings.

15 Jul 2010

Evotec to acquire DeveloGen

Evotec AG today announced the signing of a definitive agreement to acquire DeveloGen, a biopharmaceutical company engaged in the discovery of novel therapeutic approaches for the treatment of metabolic and endocrine disorders, for up to €14m in shares plus performance-related deferred payments (earn-out).

15 Jul 2010

Research provides better understanding of drugs used to treat, prevent cardiovascular disease

Using chemical labeling and mass spectrometry-based techniques, Mark Chance, PhD, director of the Case Western Reserve University School of Medicine Center for Proteomics and Bioinformatics and professor of physiology and biophysics; Sayan Gupta, PhD, instructor at the Case Center for Proteomics and Bioinformatics; and a research team from the University of Oxford, for the first time, were able to take a high resolution picture of the open state of a K+ channel, allowing them to comparatively analyze gating mechanisms important to heart function and nerve signaling - in addition these techniques have already permitted Case Western investigators to gain a deeper understanding of G-protein coupled receptors.

14 Jul 2010

Maven Semantic announces updates to database of Toxicology researchers

Maven Semantic announces updates to their Toxicology database.

14 Jul 2010

Exercise can reverse effects of early-life trauma

Athletes have long known about the natural “high” exercise can induce. Now, for the first time, medical researchers have demonstrated that exercise can reverse the effects in the brain of psychological trauma experienced early in life.

13 Jul 2010

Scientists receive $1.6M in new funding to advance healthcare research

University of Montreal scientists have received $1.6 in new funding to advance healthcare research over the next three years, as part of a Government of Canada announcement to support 31 research projects at 12 universities across the nation. Some $13 million in funding, from the Collaborative Health Research Projects program, will be awarded over three years to foster collaborations between scientists from the natural, engineering and health sciences.

13 Jul 2010

Pharmacology News and Research

Latest Pharmacology News and Research

GRB7 gene drives an aggressive form of breast cancer, researchers find

Protein parkin essential for hypothalamic neurons recovery in Parkinson's disease patients

New research identifies stem cells that generate three critical classes of nerve cells

Gladstone Institutes, H. Lundbeck collaborate to identify therapeutic candidates for neurological diseases

Five new large pharma clients place initial studies with LAB Research

Major turning point in antiepileptic drug testing, development

Researchers reveal findings on restricted lineage of iPS cells

Cellectis bioresearch introduces new technology to develop cell-based assays for HTS studies

ZIOPHARM Oncology commences palifosfamide Phase III clinical trial for metastatic soft tissue sarcoma

Researchers identify a mechanism that explains different phases of CML progression

Researchers to receive $1.2M from Susan G. Komen for the Cure for breast cancer research

ICON opens purpose-built clinical pharmacology unit within CMFT campus

ArmaGen uses BBB molecular Trojan horse platform technology to create brain penetrating form of human EPO

Study reveals anti-diabetic properties of cashew seed extract

NIH awards $38.2M grant to Georgetown-Howard Universities Center for Clinical and Translational Science

Evotec to acquire DeveloGen

Research provides better understanding of drugs used to treat, prevent cardiovascular disease

Maven Semantic announces updates to database of Toxicology researchers

Exercise can reverse effects of early-life trauma

Scientists receive $1.6M in new funding to advance healthcare research

Industry Focus - Biopharma eBook

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Pharmacology News and Research

Latest Pharmacology News and Research

Industry Focus - Biopharma eBook

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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