Serotonin

Serotonin is one of several chemical messengers in the brain, or neurotransmitters, which help brain cells communicate with one another. Among many other functions, serotonin is involved in regulating mood. Problems with making or using the right amount of serotonin have been linked to many mental disorders, including depression, bipolar disorder, anxiety disorder, autism, and schizophrenia.

What is Serotonin?

Serotonin is an example of a neurotransmitter, a chemical messenger that is passed between nerve cells. When a nerve impulse reaches the axon at the end of a nerve, neurotransmitters are released which cross an area called the synapse to be received by a specific receptor on the end of a target nerve. Once received by the target nerve, the neurotransmitter may either excite that nerve to fire its own signal or prevent it from firing the signal.

Serotonin Function

Serotonin Biosynthesis

Drugs Targeting the 5-HT System

Serotonin Pathology

Serotonin in Plants

The Relationship Between Serotonin and 5-HTP

Do Serotonin and Antidepressants Affect the Microbiome?

Serotonin and Aggression

Latest Serotonin News and Research

Study finds 24-hour fasting cycles enhance libido in male mice

Long-term fasting in 24-hour cycles increases the sex drive of male mice by lowering the concentration of the neurotransmitter serotonin in the brain.

28 Mar 2025

Flavonoids help regulate gut hormones and show promise in managing type 2 diabetes

Flavonoids show promise in treating type 2 diabetes mellitus by targeting the enteroendocrine system and regulating key gut hormones. They enhance insulin sensitivity, reduce oxidative stress, and influence appetite, glucose uptake, and hormone secretion.

26 Mar 2025

Women with premenstrual syndrome appear to find relief from symptoms with placebos

Women affected by premenstrual syndrome (PMS) appear to experience less intense and debilitating symptoms after taking placebo pills even when told they do not contain any active medication, suggests a study published in the open-access journal BMJ Evidence-Based Medicine.

25 Mar 2025

Cordycepin helps tired mice run longer and think better, study finds

Researchers show that cordycepin, a compound from Cordyceps militaris, can boost endurance and protect brain function in mice exhausted by excessive exercise.

10 Mar 2025

Does a vegetarian diet help or harm your brain? Here’s what the science reveals

A recent study in Nutrients examines the effects of vegetarian and vegan diets on neurological health, highlighting both benefits and potential nutrient deficiencies that impact cognitive function.

3 Mar 2025

The brain-gut microbiota axis: Impact on mental health & potential treatment avenues

To be decided by the editor

From Atlantia Clinical Trials 28 Feb 2025

Study explores link between antidepressant use and cognitive decline in dementia patients

New research suggests that antidepressants can accelerate cognitive decline in people with dementia. At the same time, some drugs appear to be less harmful than others, which can help doctors make better treatment decisions, according to the study published in BMC Medicine.

25 Feb 2025

Can chili peppers improve ADHD symptoms? Scientists explore their gut-brain connection

Chili peppers may influence ADHD symptoms by modulating the gut microbiome, with capsaicin, vitamin C, and omega-3 fatty acids showing potential effects on neurotransmitters and inflammation. However, clinical trials are needed to confirm their efficacy.

20 Feb 2025

Common antidepressant Fluoxetine protects from sepsis-induced death

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19 Feb 2025

New review maps the impact of reproductive hormones on neurological health

A comprehensive review published today in Brain Medicine by leading neuroendocrinologist Professor Hyman M. Schipper from McGill University's Department of Neurology and Neurosurgery maps out the extensive influence of reproductive hormones on neurological health and disease.

18 Feb 2025

Prozac's surprising immune-boosting effects could lead to new treatments for sepsis

Antidepressants like Prozac are commonly prescribed to treat mental health disorders, but new research suggests they could also protect against serious infections and life-threatening sepsis.

14 Feb 2025

Study finds cerebellar serotonin as a "brake" to alleviate anxiety

Understanding the neural circuits that drive anxiety may help researchers discover circuit-specific targets and therefore increase the precision of treatment strategies.

10 Feb 2025

Study reveals copper may raise fibromyalgia risk, iron could offer relief

A new study using Mendelian randomization suggests that higher copper levels may increase fibromyalgia risk, while iron may have a protective effect.

3 Feb 2025

Anxiety reduction with antidepressants confirmed, long-term effects uncertain

A new Cochrane review confirms that antidepressants effectively reduce symptoms of generalized anxiety disorder (GAD) under trial conditions, although there is limited data on long-term usage.

30 Jan 2025

Antidepressant fluoxetine found ineffective for early COVID-19 treatment

Findings reveal fluoxetine's weak antiviral effects in COVID-19, with no significant benefits in symptom resolution compared to other antiviral treatments.

22 Jan 2025

Exploring the use of genomic classifier tests in prostate cancer risk stratification

A systematic review found that while genomic classifier (GC) tests may influence risk classifications or treatment decisions for patients with localized prostate cancer (PCa), there is a need for better data on their cost-effectiveness, clinical utility, and their impact on racial and ethnic groups, particularly Black men.

20 Jan 2025

Mapping neuronal IL-1R1 expression reveals insights into brain function

Interleukin-1 (IL-1) is a key molecule involved in inflammation and plays an important role in both healthy and diseased states.

17 Jan 2025

Maternal medications linked to changes in protein and fat levels in human milk

The impact of maternal antidepressant and anti-inflammatory use on breast milk composition shows reduced protein and fat levels, affecting infant nutrition.

9 Jan 2025

Monoamine neurotransmitters emerge as architects of brain physiology

A collaborative effort between Mount Sinai and Memorial Sloan Kettering Cancer Center has shed valuable light on how monoamine neurotransmitters such as serotonin, dopamine, and now histamine help regulate brain physiology and behavior through chemical bonding of these monoamines to histone proteins, the core DNA-packaging proteins of our cells.

9 Jan 2025

Study reveals brain circuits and chemical messengers behind the regulation of meal initiation

When you are feeling hungry, the brain takes the necessary steps toward consuming a meal. Many of these steps are not well known, but a new study published in the journal Metabolism by researchers at Baylor College of Medicine and the University of Texas Health Science Center at Houston reveals brain circuits and chemical messengers that contribute to the regulation of meal initiation and food intake.

20 Dec 2024