Sickle Cell Anemia News and Research

Latest Sickle Cell Anemia News and Research

Sangamo BioSciences starts Phase 2 clinical studies to develop functional cure for HIV/AIDS

Sangamo BioSciences, Inc. announced today the initiation of two new Phase 2 clinical studies (SB-728-1101 and SB-728-902, Cohort 5) in its program to develop a "functional cure" for HIV/AIDS.

9 Jan 2012

Research assesses safety and efficacy of pre-operative transfusions, hydroxyurea therapy for SCD

Research assessing the safety and efficacy of hydroxyurea therapy in pediatric patients with sickle cell disease (SCD) and the use of pre-operative transfusions for patients with SCD who undergo low- and moderate-risk elective surgery will be presented today at the 53rd Annual Meeting of the American Society of Hematology.

12 Dec 2011

New gene editing technique can heal sickle cell patients with their own cells

Researchers at the Salk Institute for Biological Studies have developed a way to use patients' own cells to potentially cure sickle cell disease and many other disorders caused by mutations in a gene that helps produce blood hemoglobin.

8 Dec 2011

GE Healthcare, UCSF collaborate for cord blood project

UCSF and the Cell Technologies business of GE Healthcare Life Sciences have begun a unique collaboration aimed at overcoming the lack of blood-forming stem cells available to patients suffering from life-threatening diseases such as lymphoma, myeloma, leukemia or sickle cell anemia.

6 Dec 2011

Scientists solve mystery behind why people with defective hemoglobin do not contract malaria

Why do people with a hereditary mutation of the red blood pigment hemoglobin not contract severe malaria? Scientists in the group headed by Prof. Michael Lanzer of the Department of Infectious Diseases at Heidelberg University Hospital have now solved this mystery.

19 Nov 2011

Hemoglobin levels, blood pressure and male gender linked to higher risk of silent strokes in SCA children

Factors such as low hemoglobin levels, increased systolic blood pressure, and male gender are linked to a higher risk of silent cerebral infarcts (SCIs), or silent strokes, in children with sickle cell anemia (SCA), according to results from a large, first-of-its-kind study published online today in Blood, the Journal of the American Society of Hematology (ASH).

17 Nov 2011

Light-cell interaction and Born approximation rule can help detect misshapen red blood cells

Misshapen red blood cells are a sign of serious illnesses, such as malaria and sickle cell anemia. Until recently, the only way to assess whether a person's RBCs were the correct shape was to look at them individually under a microscope - a time-consuming process for pathologists.

1 Nov 2011

BCL11A protein might serve as potential target for sickle cell disease

Flipping a single molecular switch can reverse illness in a model of sickle cell disease, according to a study by researchers at Children's Hospital Boston and Dana-Farber Cancer Institute. When turned off, the switch, a protein called BCL11A, allows the body to manufacture red blood cells with an alternate form of hemoglobin unaffected by the mutation that causes the disease.

14 Oct 2011

Potential new protein target for sickle cell disease

National Institutes of Health-funded scientists have corrected sickle cell disease in adult laboratory mice by activating production of a special blood component normally produced before, but not after, birth.

14 Oct 2011

Researchers use patient's own stem cells to correct genetic alteration that causes SCD

Using a patient's own stem cells, researchers at Johns Hopkins have corrected the genetic alteration that causes sickle cell disease (SCD), a painful, disabling inherited blood disorder that affects mostly African-Americans. The corrected stem cells were coaxed into immature red blood cells in a test tube that then turned on a normal version of the gene.

29 Sep 2011

Jefferson's two-step bone marrow transplant procedure holds promise for cancer patients

Half-matched bone marrow or stem cell transplants for blood cancer patients have typically been associated with disappointing clinical outcomes. However, a clinical trial conducted at the Kimmel Cancer Center at Jefferson testing its unique, two-step half-match procedure has produced some promising results: the probability of overall survival was 45 percent in all patients after three years and 75 percent in patients who were in remission at the time of the transplant.

2 Sep 2011

EGT transfers clinical grade lentiviral vector to MSKCC

Errant Gene Therapeutics, LLC, a pioneering boutique drug development firm specializing in Rare Diseases, announced the transfer of its clinical grade lentiviral vector, TNS 9.55.3, to Memorial Sloan Kettering Cancer Center.

29 Jul 2011

genOway acquires worldwide exclusive license for RMCE technology from bluebird bio for genetically modified rodents

genOway and bluebird bio report today genOway acquisition of an exclusive worldwide license for the RMCE technology (developed at the Massachusetts Institute of Technology) in the field of genetically modified rodents.

12 Jul 2011

Transplants with half-matched bone marrow or cord blood are comparable to fully matched tissue

Identifying a suitable donor for leukemia and lymphoma patients who need bone marrow transplants may be far easier now that results of two clinical trials show transplant results with half-matched bone marrow or umbilical cord blood are comparable to fully matched tissue, thanks in large part to the availability of effective antirejection drugs and special post-transplant chemotherapy.

8 Jul 2011

Half-matched transplants widen donor pool for leukemia and lymphoma

7 Jul 2011

Los Alamos National Lab scientists win three R&D Magazine's 2011 awards

Los Alamos National Laboratory scientists have won three of R&D Magazine's 2011 R&D100 Awards. Recognized as the "Oscars of Invention" by the Chicago Tribune, these awards honor the top 100 proven technological advances of the past year.

23 Jun 2011

Research provides better understanding of interplay between genomes of malaria parasites, humans

For tens of thousands of years, the genomes of malaria parasites and humans have been at war with one another. Now, University of Pennsylvania geneticists, in collaboration with an international team of scientists, have developed a new picture of one way that the human genome has fought back.

10 Jun 2011

Hydroxyurea safe and effective for infants, toddlers with sickle-cell disease

In what is being hailed as a significant advance in the treatment of children with sickle cell anemia, a drug commonly used to treat adults has been shown to be safe and effective in children.

13 May 2011

UH chemist receives prestigious Sloan award for next-generation computer memory

Investigating the building blocks for next-generation computer memory has earned a University of Houston chemist his third Tier One research award.

10 May 2011

Researchers unravel mechanism behind sickle hemoglobin protection against malaria

The latest issue of the journal Cell carries an article that is likely to help solve one of the long-standing mysteries of biomedicine. In a study that challenges currently held views, researchers at the Instituto Gulbenkian de Ci-ncia, in Portugal, unravel the molecular mechanism whereby sickle cell hemoglobin confers a survival advantage against malaria, the disease caused by Plasmodium infection.

29 Apr 2011

Sickle Cell Anemia News and Research

Latest Sickle Cell Anemia News and Research

Sangamo BioSciences starts Phase 2 clinical studies to develop functional cure for HIV/AIDS

Research assesses safety and efficacy of pre-operative transfusions, hydroxyurea therapy for SCD

New gene editing technique can heal sickle cell patients with their own cells

GE Healthcare, UCSF collaborate for cord blood project

Scientists solve mystery behind why people with defective hemoglobin do not contract malaria

Hemoglobin levels, blood pressure and male gender linked to higher risk of silent strokes in SCA children

Light-cell interaction and Born approximation rule can help detect misshapen red blood cells

BCL11A protein might serve as potential target for sickle cell disease

Potential new protein target for sickle cell disease

Researchers use patient's own stem cells to correct genetic alteration that causes SCD

Jefferson's two-step bone marrow transplant procedure holds promise for cancer patients

EGT transfers clinical grade lentiviral vector to MSKCC

genOway acquires worldwide exclusive license for RMCE technology from bluebird bio for genetically modified rodents

Transplants with half-matched bone marrow or cord blood are comparable to fully matched tissue

Half-matched transplants widen donor pool for leukemia and lymphoma

Los Alamos National Lab scientists win three R&D Magazine's 2011 awards

Research provides better understanding of interplay between genomes of malaria parasites, humans

Hydroxyurea safe and effective for infants, toddlers with sickle-cell disease

UH chemist receives prestigious Sloan award for next-generation computer memory

Researchers unravel mechanism behind sickle hemoglobin protection against malaria

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Sickle Cell Anemia News and Research

Latest Sickle Cell Anemia News and Research

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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