T Cell News and Research

Latest T Cell News and Research

Alternate view for pathology of Alzheimer's disease

A new paper from researchers at the Case Western Reserve University School of Medicine challenges the classic theory that the nerve tangles seen in the brains of Alzheimer's disease (AD) victims are the cause of the disease, but rather proposes that they are a protective response to the disease. Their paper appears in the April issue of the journal Trends in Molecular Medicine.

19 Apr 2005

Gene expression pattern predicts multiple drug resistance

St. Jude Children's Research Hospital discovery of genetic links to multi-drug resistance gives clinicians new insight into the cause of treatment failure and suggests targets for novel anti-leukemic drugs

19 Apr 2005

Researchers determine structure of binding site of colon-cancer drug Erbitux and its protein target

Researchers at the University of Pennsylvania School of Medicine have determined the precise molecular details of how Erbitux, a recently approved colorectal cancer drug, binds to its target on cancer cells. Knowing this chemical configuration will lead to better drug design for this family of cancer medications.

19 Apr 2005

Scientists reveal the shape of a protein that helps retroviruses break into cells

Retroviruses are among the trickier and more malicious disease agents, causing AIDS and cancers such as leukemia. The viruses manage to sneak into cells with the help of special protein assemblies scattered all over their surfaces. These retrovirus surface proteins cause the membrane envelope of the virus to fuse with the membrane of the cell, spilling virus RNA into the cell to wreak damage.

13 Apr 2005

Link between insomnia and obesity

A possible link between lack of sleep (insomnia) and obesity has been traced to hypocretin/orexin cells in the hypothalamus region of the brain that are easily excited and sensitive to stress, Yale School of Medicine researchers report in the April issue of Cell Metabolism.

13 Apr 2005

Researchers show why mutations in a certain few genes, such as the p53 tumor suppressor gene, are found in different cancers

Scientists have identified some of the first genetic triggers for cancer as mutations in specific oncogenes or tumor suppressor genes. Full-blown tumors and metastatic cancers, however, often exhibit many genetic mutations, sometimes dozens in a given tumor. An important scientific question, and one with significant clinical implications, has been what happens after the initial mutation that leads to dangerous later-stage cancers with multiple damaged genes.

13 Apr 2005

Scientists have discovered the mechanism that enables some CD4 T cells - the main target of HIV - to thwart the virus

The discovery, reported on April 13 in the online version of Nature, could open the door to an entirely new strategy for preventing the spread of HIV infection in the body's cells, according to the senior author of the study, Gladstone Institute of Virology and Immunology Director Warner C. Greene, MD, PhD.

13 Apr 2005

Scientists use transcription factors to increase insulin production in diabetic mice

A group of Japanese scientists has used gene therapy to deliver three insulin transcription factors, MafA, PDX-1, and NeuroD, to the livers of diabetic mice. As a result, the mice experienced an increase in insulin gene expression and insulin production, raising the possibility that this could eventually be used to treat diabetes.

13 Apr 2005

Breakthough in stem cell research - three clones of cells from existing human embryonic stem cells

In an Australian first, UNSW researchers have developed three clones of cells from existing human embryonic stem cells. The breakthrough could lead to new treatments for conditions such as diabetes, Parkinson’s disease and spinal cord injury.

13 Apr 2005

New invention can easily spot whether cancer has spread

German researchers have come up with a test that measures how stretchy cells are, which could revolutionise the way doctors spot whether cancers have spread, Inventors at the University of Leipzig have produced a laptop-sized gadget which can give a diagnosis using as few as 50 cells and avoids the need to cut out tissue and say it is 1,000 times more accurate than traditional tests.

12 Apr 2005

Chemical library aids in developing drug system for nerve damage

A researcher studying drug design for nerve damage therapies has gotten her answer to questions by following some old advice: she used the library.

12 Apr 2005

Unconventional wiring of the brain circuits that govern sleep and waking might explain the prevalence of insomnia

Unconventional wiring of the brain circuits that govern sleep and waking might explain the prevalence of insomnia and the condition's association with obesity, according to new work published in the April issue of Cell Metabolism. Characterized by a chronic inability to fall asleep or remain sleeping, insomnia is estimated to affect one in every eight Americans.

12 Apr 2005

New findings about insulin-signaling in the liver could prove useful in understanding type 2 diabetes

A collaborative effort led by The Burnham Institute's Gen-Sheng Feng has created a mouse with improved glucose tolerance and insulin activity in the liver, and generated new findings about insulin-signaling in the liver that could prove useful in understanding the pathogenesis of type 2 diabetes.

12 Apr 2005

Obesity linked to diabetes

A research team headed by Professor Helena Edlund at Umeå University has achieved a breakthrough in our understanding of how obesity causes increased levels of insulin, sugar, and blood fats leading to diseases like type-2 diabetes and liver degeneration. The findings also indicate a direct way to prevent these diseases.

12 Apr 2005

Eat your fruits and veggies - your body will thank you and your mother will be happy!

Eat your fruits and veggies - your body will thank you and your mother will be happy! And if that's not reason enough, a new study suggests antioxidant-rich fruits and vegetables may limit brain damage from stroke and other neurological disorders.

12 Apr 2005

Protein that regulates cholesterol levels may lead to new drug targets in the fight against obesity

A protein that regulates cholesterol levels in the body also is responsible for maintaining a healthy balance between fat storage and fat burning, according to a UT Southwestern Medical Center study that may lead to new drug targets in the fight against obesity.

12 Apr 2005

New test for cancer, more sensitive than any existing techniques

Speaking at the Institute of Physics conference Physics 2005 in Warwick, scientists will reveal a new test for cancer, more sensitive than any existing technique and capable of predicting for the first time whether a tumour has spread.

12 Apr 2005

Breakdown in brain cell communication may contribute to the most common biochemical cause of mental retardation

The process is akin to a baseball game gone bad. Imagine if a pitcher were joined by six players simultaneously winding up on the mound. Crouched behind home plate, the single catcher would soon be overwhelmed. Even if the coach sent in teammates to catch the extra balls, confusion would reign on the field.

12 Apr 2005

Advance in genetics of cleft lip and palate

Cleft lip and/or palate remains one of the most common birth defects in the world. It occurs when the sides of the face fuse abnormally in a developing baby, resulting in a malformed lip and/or roof of the mouth.

12 Apr 2005

Cardiac stem cells come closer to clinic

The laboratory of MDA grantee Kenneth Chien at the University of California-San Diego announced in a recent issue of Nature that its researchers have discovered in the hearts of mice, rats and humans a new type of stem cell that can become a mature cardiac cell.

12 Apr 2005

T Cell News and Research

Latest T Cell News and Research

Alternate view for pathology of Alzheimer's disease

Gene expression pattern predicts multiple drug resistance

Researchers determine structure of binding site of colon-cancer drug Erbitux and its protein target

Scientists reveal the shape of a protein that helps retroviruses break into cells

Link between insomnia and obesity

Researchers show why mutations in a certain few genes, such as the p53 tumor suppressor gene, are found in different cancers

Scientists have discovered the mechanism that enables some CD4 T cells - the main target of HIV - to thwart the virus

Scientists use transcription factors to increase insulin production in diabetic mice

Breakthough in stem cell research - three clones of cells from existing human embryonic stem cells

New invention can easily spot whether cancer has spread

Chemical library aids in developing drug system for nerve damage

Unconventional wiring of the brain circuits that govern sleep and waking might explain the prevalence of insomnia

New findings about insulin-signaling in the liver could prove useful in understanding type 2 diabetes

Obesity linked to diabetes

Eat your fruits and veggies - your body will thank you and your mother will be happy!

Protein that regulates cholesterol levels may lead to new drug targets in the fight against obesity

New test for cancer, more sensitive than any existing techniques

Breakdown in brain cell communication may contribute to the most common biochemical cause of mental retardation

Advance in genetics of cleft lip and palate

Cardiac stem cells come closer to clinic

Immunology eBook

CellVoyant's AI-Powered Vision for the Future of Cell Therapy

Scalable, Smart, and Accessible: The Future of Lab Automation

Healthy Beginnings, Hopeful Futures: A Conversation with WHO’s Dr. Allotey

T Cell News and Research

Latest T Cell News and Research

Immunology eBook

CellVoyant's AI-Powered Vision for the Future of Cell Therapy

Scalable, Smart, and Accessible: The Future of Lab Automation

Healthy Beginnings, Hopeful Futures: A Conversation with WHO’s Dr. Allotey

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