Typhoid Fever

Typhoid fever is a life-threatening illness caused by the bacterium Salmonella Typhi. Typhoid fever is still common in the developing world, where it affects about 21.5 million persons each year.

What is Typhoid?

Typhoid fever is an infection caused by a strain of bacteria called Salmonella typhii, which is related to the bacteria that causes salmonella food poisoning. The infection can affect the whole body and damage multiple organs. Unless treated, this infection can have life threatening consequences.

Typhoid Symptoms

Typhoid Diagnosis

Typhoid Treatment

Typhoid Prevention

Typhoid Fever History

Latest Typhoid Fever News and Research

Researchers uncover mechanism of protein GBP1 in immune defense

The protein GBP1 is a vital component of our body's natural defence against pathogens. This substance fights against bacteria and parasites by enveloping them in a protein coat, but how the substance manages to do this has remained unknown until now.

12 Oct 2024

New study highlights the urgent need for typhoid vaccination in sub-Saharan Africa

There is a high burden of typhoid fever in sub-Saharan African countries, according to a new study published today in The Lancet Global Health.

12 Mar 2024

Global health boost as new vaccine SKYTyphoid gains WHO prequalification

SK bioscience and the International Vaccine Institute (IVI) announced today that the typhoid conjugate vaccine developed by SK bioscience with technology transfer from IVI has achieved the World Health Organization prequalification (PQ), which paves the way for public procurement of the vaccine by UN organizations and gives a boost to the global TCV supply.

23 Feb 2024

Evidence from Malawi: Typhoid conjugate vaccine provides protection for up to four years

Study shows that a single dose of typhoid conjugate vaccine provides over four years of protection against typhoid fever in Malawian children, proving effective across all age groups.

31 Jan 2024

Tomato juice can get rid of enteric bacteria that can harm people's health

Tomato juice can kill Salmonella Typhi and other bacteria that can harm people's digestive and urinary tract health, according to research published this week in Microbiology Spectrum, a journal of the American Society for Microbiology. Salmonella Typhi is a deadly human-specific pathogen that causes typhoid fever.

30 Jan 2024

Clinical study supports the long-lasting impacts of typhoid conjugate vaccine

A single dose of the typhoid conjugate vaccine, Typbar TCV, provides lasting efficacy in preventing typhoid fever in children ages 9 months to 12 years old, according to a new study conducted by researchers at University of Maryland School of Medicine's (UMSOM) Center for Vaccine Development and Global Health (CVD) and led by in-country partners at the Malawi-Liverpool Wellcome Trust (MLW) Clinical Research Programme.

25 Jan 2024

Bio Farma's Bio-TCV typhoid conjugate vaccine licensed in Indonesia following marketing approval

The International Vaccine Institute (IVI), an international organization with a mission to discover, develop, and deliver safe, effective, and affordable vaccines for global health, and Bio Farma, a biotechnology company based in West Java, Indonesia, announced today that Bio Farma's Bio-TCV typhoid conjugate vaccine (TCV) was licensed in Indonesia following marketing approval from Badan Pengawas Obat dan Makanan (BPOM), the national regulatory authority.

9 Nov 2023

Advancing the development of vaccines through recombinant technology

In this interview, News-Medical talks to Dr. Amy Sheng, the head of CRO at Sino Biological, about current developments in the field of vaccine development through recombinant techniques.

From Sino Biological Inc. 4 May 2023

Tissue-resident memory cells are key to immunity to Salmonella in mice

Salmonella infections cause about a million deaths a year worldwide, and there is an urgent need for better vaccines for both typhoid fever and non-typhoidal Salmonella disease.

18 Apr 2023

Study demonstrates safety and efficacy of a three-dose whole-parasite vaccine against malaria

A three-dose regimen of a whole-parasite vaccine against malaria – called Plasmodium falciparum sporozoite (PfSPZ) vaccine – demonstrated safety and efficacy when tested in adults living in Burkina Faso, West Africa, which has endemic malaria.

4 Jan 2023

Antibiotic-resistant strains of typhoid bacteria continue to spread out of South Asia

Antibiotic-resistant strains of Salmonella Typhi, the typhoid bacteria, have spread from South Asia to other countries nearly 200 times since 1990, new research suggests.

29 Jun 2022

Drug-resistant typhoid needs to be treated as a global problem

The bacteria that causes typhoid fever is becoming increasingly resistant to common antibiotics used to treat the disease, with resistant strains spreading to hundreds of countries in the past three decades, new analysis shows.

29 Jun 2022

Bacteria causing typhoid fever are highly developing antibiotic resistance

Bacteria causing Typhoid fever are becoming increasingly resistant to some of the most important antibiotics for human health, according to a study published in The Lancet Microbe journal. The largest genome analysis of Salmonella enterica serovar Typhi (S. Typhi) also reveals that resistant strains - almost all originating in South Asia - have spread to other countries nearly 200 times since 1990.

22 Jun 2022

World Immunization Week 2022: Striving for a Long Life for All with the International Vaccine Institute

As part of World Immunization Week 2022, News Medical speaks to the International Vaccine Institute about their fight against vaccine inequity, as well as what a “Long Life for All” means to them.

25 Apr 2022

Study assesses how vaccination against typhoid fever could help avert antimicrobial resistance

Researchers from Yale University, University of Basel, University of Antwerp, CDDEP and other institutions recently published 'Estimating the effect of vaccination on antimicrobial-resistant typhoid fever in 73 countries supported by Gavi: a mathematical modeling study' in The Lancet Infectious Diseases.

4 Feb 2022

COVID-19 first wave increased the sale of antibiotic formulations in India

The first wave of COVID-19 in 2020 in India saw a substantial increase in the sale of antibiotic formulations used in adults and adolescents, especially azithromycin, says a study.

19 Jul 2021

Role of traditional medicine against SARS-CoV-2

A group of researchers at Kannur University reviewed selected papers and in silico work on potential drug leads that could be used to manage COVID-19.

13 Jun 2021

Covid strikes clergy as they comfort pandemic’s sick and dying

The Rev. Jose Luis Garayoa survived typhoid fever, malaria, a kidnapping and the Ebola crisis as a missionary in Sierra Leone, only to die of Covid-19 after tending to the people of his Texas church who were sick from the virus and the grieving family members of those who died.

23 Feb 2021

Antimicrobial resistance to critical drugs spirals in low- and middle-income countries

As antibiotic use grows in lower-income countries so does antibiotic resistance, says report.

20 Feb 2021

Vi-DT typhoid conjugate vaccine met primary endpoints in phase III study

Vi-DT typhoid conjugate vaccine, developed jointly by the International Vaccine Institute (IVI) and SK bioscience, has met the primary endpoints in a phase III study in Nepal.

17 Dec 2020