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Signs and symptoms of lung problems:
shortness of breath
chest pain
coughing
Signs and symptoms of problems with your intestines:
diarrhoea or more bowel movements than usual
your stools are black, tarry, sticky or have blood or mucus
severe stomach pain or tenderness
Signs and symptoms of liver problems:
nausea or vomiting
feeling less hungry
pain on the right side of your stomach
your skin looks yellow
the whites of your eyes look yellow
dark urine
you bleed or bruise more easily than normal
Signs and symptoms of kidney problems:
changes in the amount or colour of your urine
Signs and symptoms of hormone gland problems (especially the thyroid, pituitary, and
adrenal glands):
rapid heartbeat
weight loss
increased sweating
weight gain
hair loss
feeling cold
constipation
your voice gets deeper
muscle aches
dizziness or fainting
headaches that will not go away or unusual headache
Signs and symptoms of blood sugar problems:
feeling more hungry or thirsty
needing to urinate more often
weight loss
Signs and symptoms of skin problems:
rash
itching
skin blistering, peeling or sores
ulcers in mouth or in lining of nose, throat, or genital area
Signs and symptoms of problems in other organs:
muscle pain or weakness
changes in eyesight
stomach area pain with nausea and vomiting (pancreatitis)
confusion, fever, memory problems, or seizures (encephalitis)
swollen lymph nodes, rash or tender lumps on skin, cough, or eye pain (sarcoidosis)
shortness of breath, irregular heartbeat, feeling tired, or chest pain (myocarditis)
inflammation of the heart muscle, which may present as shortness of breath, irregular
heartbeat, feeling tired, or chest pain (pericarditis)
inflammation of the covering of the heart and accumulation of fluid around the heart
(pericardial effusion)
inflammation of the nerves that may cause pain, weakness, and paralysis in the arms
and legs (peripheral neuropathy)
pain, numbness, tingling, or weakness in the arms or legs; bladder or bowel problems
including needing to urinate more frequently, urinary incontinence, difficulty urinating
and constipation (myelitis)
inflammation of the blood vessels (vasculitis)
decreased function of the parathyroid gland, which may include muscle cramps or spasms,
fatigue and weakness (hypoparathyroidism)
inflammation of the stomach lining, which may include severe stomach pain or tenderness,
nausea or vomiting (gastritis)
destruction of red blood cells, which may include dark urine, pale or yellow skin/eyes,
lightheadedness, feeling tired, rapid heartbeat, or shortness of breath (haemolytic
anaemia)
pain in the upper right part of the stomach, swelling of the liver or spleen, fatigue,
itching or yellowing of the skin or the whites of the eyes (sclerosing cholangitis)
decreased ability of the pancreas to make digestive enzymes, which may include diarrhoea
with loose and oily stools, weight loss, metabolic bone disease, and vitamin or mineral
deficiencies (exocrine pancreatic insufficiency)
Signs and symptoms of infusion (IV) reactions:
shortness of breath
itching or rash
dizziness
fever
There are possible side effects of treatment with KEYTRUDA in people who have received
a transplant:
Rejection of a transplanted organ.
People who have had an organ transplant may have an increased risk of organ transplant
rejection. Your doctor should tell you what signs and symptoms you should report and
monitor you, depending on the type of organ transplant that you have had.
Complications, including graft-versus-host-disease (GVHD), in people with bone marrow
(stem cell) transplant that uses donor stem cells (allogeneic).
These complications can be severe and can lead to death. They may occur if you had
this kind of transplant in the past or if you get it in the future. Your doctor will
monitor you for the following signs and symptoms: skin rash, liver inflammation, abdominal
pain, and diarrhoea.
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