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Lung problems:
Problems with your lungs such as breathing difficulties, shortness of breath, or cough.
These may be signs of inflammation of the lungs (pneumonitis or interstitial lung
disease)
Stomach and Intestinal problems:
Inflammation of the intestines (colitis), stomach (gastritis) and duodenum (duodenitis)
which can worsen to bleeding or bowel perforation
Symptoms may include diarrhoea (watery, loose or soft stools), an increased number
of bowel movements (an increase by two or more per day), constipation, vomiting, nausea,
mucus and blood in your stools, or darker-coloured stools, stomach pain or tenderness
in your stomach area
Liver problems:
Inflammation of the liver (hepatitis)
Symptoms may include yellowing of the eye or skin (jaundice), pain on the right side
of your stomach area or tiredness
Kidney problems:
Inflammation in the kidney (nephritis)
Signs and symptoms may include abnormal kidney function tests, decreased volume of
urine and kidney failure (including abrupt loss of kidney function)
Hormone gland problems:
Damage or inflammation of hormone producing glands. Symptoms may include headaches,
blurry or double vision, fatigue, decreased sexual drive, behavioural changes.
Underactive function of the pituitary gland
Underactive function of the thyroid gland which can cause tiredness or weight gain
Overactive function of the thyroid which can cause rapid heart rate, sweating and
weight loss
Decreased function of the adrenal glands caused by an underactive hypothalamus part
of the brain) or an overactive pituitary gland (a small gland at the base of the brain)
Defect in gland producing sex hormones
Acid in the blood produced by diabetes (diabetic ketoacidosis)
Excessive thirst, the passing of a greatly increased amount of urine, increase in
appetite with a loss of weight, feeling tired, drowsy, weak, depressed, irritable
and generally unwell (diabetes)
Skin problems:
Severe and possibly fatal peeling of the skin (toxic epidermal necrolysis, Steven-Johnson
syndrome) and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Signs and symptoms of severe skin reaction may include skin rash with or without itching,
peeling of the skin, dry skin, fever, fatigue, swelling of the face or lymph glands,
increase of eosinophils (type of white blood cells) and effects on liver, kidneys
or lungs
Severe condition of the skin that causes red, often itchy spots, similar to rash of
measles, which starts on the limbs and sometimes on the face and the rest of the body
(erythema multiforme), skin disease with thickened patches of red skin, often silvery
scales (psoriasis), hives (itchy, bumpy rash)
Brain and nervous system problems:
Damage to nerves causing numbness and weakness (polyneuropathy)
Inflammation of the brain (encephalitis)
A condition in which the muscles become weak and tire easily (myasthenic syndrome)
Inflammation of the nerves caused by the body attacking itself, causing numbness,
weakness, tingling or burning pain (autoimmune neuropathy)
A temporary inflammation of the nerves that causes pain, weakness and paralysis in
the extremities (Guillain Barre syndrome)
Dizziness
Excessive accumulation of fluid on the brain,
Difficulty in speaking
Damage to the nerves (causing pain, weakness and cramps)
Difficulty in coordinating movements (ataxia), shaking, twitching, brief involuntary
muscle contraction
Inflammation of the nerves, foot drop (peroneal nerve palsy)
Triad of symptoms (meningism): neck stiffness, intolerance of bright light and headache
Inflammation of the spinal cord (myelitis) causing back and neck pain, weakness in
the arms or legs, loss of bladder or bowel control
Complications of allogeneic Haematopoietic Stem Cell Transplant (HSCT):
Complications of stem cell transplant that uses donor cells (allogeneic) may occur
after treatment with YERVOY.
These complications can be severe and can lead to death. Your healthcare provider
will monitor you for signs of complications if you have an allogeneic stem cell transplant.
Problems in other organs:
Inflammation of the heart (myocarditis). Symptoms may include shortness of breath,
fatigue, palpitations or chest pain.
Changes in the rhythm or rate of the heart, abnormal heart rhythm
Disease of blood vessels, low blood pressure, feeling intense heat with sweating and
rapid heartbeat, weakness of the heart muscle, fluid around the heart
Inflammation of muscles (myositis). Symptoms may include muscle pain, stiffness, weakness,
chest pain or severe fatigue
Muscle breakdown/injury (rhabdomyolysis). Symptoms may include muscle pain, weakness,
nausea or vomiting
Eye inflammation and vision changes. Symptoms may include redness in the eye, pain
in the eye, flashes of lights or tiny specs in your vision, blurry vision and short-term
vision loss.
Solid organ transplant rejection
A condition where the immune system mistakenly destroys red blood cells (oxygen carrying
cells) and results in decreased number of red blood cells (autoimmune haemolytic anaemia).
a condition where the immune system makes too many infection-fighting cells called
histiocytes and lymphocytes that may cause various symptoms (called haemophagocytic
lymphohistiocytosis). Symptoms may include enlarged liver and/or spleen, skin rash,
lymph node enlargement, breathing problems, easy bruising, kidney abnormalities, and
heart problems.
Infusion reactions:
Allergic reaction, reaction related to the infusion of the medicine
Life threatening allergic reaction
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