Genetic support for FDA-approvals over the past decade

This article is based on a poster originally authored by Polina V. Rusina, Maria J. Falaguera, Juan Maria R. Romero, Ellen M. McDonagh, Ian Dunham* & David Ochoa in affiliation with the European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) Open Targets,  *Wellcome Sanger Institute, Wellcome Genome Campus. This poster was presented at ELRIG Drug Discovery 2023.

Since genetic evidence can identify the underlying causes of diseases, it has frequently been used as a surrogate for drug development success. An extensive retrospective analysis of the genetic basis for drug approvals during the previous 10 years was carried out by acCELLerate.

Association score > 0

FDA-approved drugs

Genetics for acceleration?

FDA-accelerated approvals were more likely to be based on genetic evidence [OR = 9.5 (2.3 - 40), p < 0.002). This correlation could indicate a focus on genetics for critical reasons, or a better knowledge of the causal relationship for faster therapies.