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How to make hybridoma-based antibody discovery more efficient

Cyto-Mine® tackles the time-consuming and labor-intensive challenges of screening extensive cell populations for rare, antigen-specific antibody-secreting cells during antibody discovery. It transforms the traditional multi-step process into a seamless, fully-integrated workflow that can be completed in just one day.

hybridoma-based antibody

The past 20 years have witnessed an extraordinary rise in monoclonal antibody-based therapeutics, with over 80 mAbs now approved for clinical use.

As these antibody-based therapies progress through clinical studies and gain approval at an accelerated pace, the growing competition and success of these treatments place increasing pressure on biopharmaceutical companies to expedite the development of new biologics.

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hybridoma-based antibody

About Sphere Fluidicslogo

Our vision

Our philosophy is simple. We combine our knowledge and resources to help you find rare and valuable biological variants, while helping you to save time, reduce costs and stay a step ahead of the competition.

Our novel single cell analysis systems offer the rapid screening and characterization of single cells. These systems are underpinned by our patented picodroplet technology, specifically designed to increase your chances of finding that rare ‘one-in-a-billion’ molecule or cell that could be an industry blockbuster.

We understand that time is of the essence. That’s why our technologies boost throughput and assay sensitivity across a range of applications. Most importantly, our flexible systems evolve alongside your changing research needs, providing an adaptable platform that helps you to meet your goals.

Our history

Founded in 2010, Sphere Fluidics is an established Life Sciences company, originally spun out from the University of Cambridge. We initially developed 25 patented products – biochips and specialist chemicals – which currently assist hundreds of customers globally with their research.

We initially focused on producing novel biochip systems and providing R&D services. We have since extended our expertise and are developing a technology platform that enables discovery in a range of growing markets through single cell analysis. Our systems make the development of new biopharmaceuticals faster and more cost-effective, improve monoclonal antibody screening, cell line development, and overall research efficiency in a number of other applications including synthetic biology, single cell diagnostics, prognostics and single cell genome editing.

The Cyto-Mine® Single Cell Analysis System is our flagship product – the first integrated, benchtop system to automatically analyse, sort and dispense millions of individual cells in just a single day.

Our partnerships

We value and are always open to discussing new collaborative, successful and innovative academic and industry partnerships to further develop and improve our single cell technologies.

Our Technology Access Programmes and Collaborative Services exist to enable academic researchers and companies alike to tap into our application-specific expertise through direct partnerships.


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