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Introduction to NGS library prep miniaturization and automation

Next-generation sequencing (NGS) has transformed the medical and biological sciences, providing improved throughput and affordability.

The cost of whole-genome sequencing has reduced considerably, from $100 million in 2001 to $200 in 2023, and the process can now be completed in under half a day. Yet the underlying principles of NGS library preparation remain largely unchanged.

NGS workflows necessitate exact liquid handling to ensure sample preservation and great throughput requirements.

This article explores approaches to automating and miniaturizing NGS workflows using low-volume, dynamic liquid handling solutions to help ensure optimal coverage and sequencing depth in any application.

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About SPT Labtech

We design and manufacture robust, reliable and easy-to-use solutions for life science

We enable life scientists through collaboration, deep application knowledge, and leading engineering to accelerate research and make a difference together. We offer a portfolio of products within sample management, liquid handling, and multiplexed detection that minimize assay volumes, reduce material handling costs and put the discovery tools back in the hands of the scientist.

At the heart of what we do

Many of our innovations have been born out of the desire to create solutions to existing customer problems; and it’s this ethos that drives SPT Labtech’s R&D efforts. Our strengths come from the trust our customers have with us to develop truly unique, automated technologies to meet their needs. We combine cutting edge science with first-rate engineering to put customers at the heart of everything we do.

A problem-solving state of mind

The substantial breadth of expertise within our company enables us to be involved in the full life cycle of our products from the initial design concept, mechanical and software engineering and prototyping, to final manufacture and sale. These qualities allow us to offer the best possible technical and mechanical support to all the equipment that we supply, hence maintaining excellent client relationships.

SPT Labtech Company Overview

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