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Liposome Research

The scientific research about liposomes and how they can be applied for use has contributed to a breakthrough method for targeted drug delivery systems. Initially discovered in the 1960s, the research following this time has explained more about their properties and how they might be used. Today, they are indicated to help in the targeted administration for a number of highly toxic drugs, as a result of the research in this area.

17 Feb 2010

Liposome Uses

Liposomes have useful properties that promote them for the use as a drug delivery system, particularly in the targeted administration for potentially toxic drugs with a narrow therapeutic index.

17 Feb 2010

MicroRNA and Disease

MicroRNAs or miRNAs represent an important class of small regulatory RNAs that are intrinsic to post-transcriptional gene control. They are approximately 22 nucleotides in length and regulate the expression of as much as 30% of all mammalian protein-encoding genes.

3 Feb 2010

MicroRNA Cellular Functions

MicroRNAs (or miRNAs) represent an abundant class of small, conserved, non-coding RNAs (approximately 22 nucleotides in length) that direct post-transcriptional regulation of gene expression. In complex organisms, miRNAs regulate a wide range of biological processes, including development, differentiation, proliferation, cell metabolism and apoptosis (programmed cell death).

3 Feb 2010

MicroRNA Biogenesis

MicroRNAs (miRNAs) represent an extensive class of small endogenous RNAs which regulate gene expression at the post-transcriptional level by messenger RNA (mRNA) cleavage or translation inhibition. A majority of multi-cellular organisms encode dozens to hundreds of miRNA genes which play important roles in the control of biologic processes.

3 Feb 2010

MicroRNA Nomenclature

MicroRNAs (miRNAs) are evolutionary conserved small non-coding RNA molecules that post-transcriptionally regulate gene expression by base-pairing to mRNAs. Recent evidence shows that miRNA-mediated gene regulation is pivotal for normal cellular functions, and as much as one-third of human mRNAs may be miRNA targets.

3 Feb 2010

What is MicroRNA?

Gene expression in cells and tissues of every complex organism is precisely controlled and largely dependent on different conditions (such as development, changes in the environment, diseases or drugs). Various cells and organ systems within such organism (including humans) contain different gene expression profiles, thus proper understanding of regulatory mechanisms involved in such expression represents one of the key issues in genomic medicine.

3 Feb 2010

RNA Discovery

The discovery of RNA began with the discovery of nucleic acids by Friedrich Miescher in 1868 who called the material 'nuclein' since it was found in the nucleus.

3 Feb 2010

RNA Synthesis

RNA is usually synthesized from DNA. The synthesis usually requires one or more enzymes like RNA polymerase. The DNA strand is used as a template or guide on which the RNA is formed. Since RNA forms the proteins, this is the way the DNA maintains the blue print for all proteins without leaving the nucleus.

3 Feb 2010

RNA Structure

RNA is a single stranded molecule containing a ribose sugar. It has a distinctive structure and, unlike DNA, there are variations and various types of RNA structures.

3 Feb 2010

Anti-VEGF Therapies

Vascular endothelial growth factor (VEGF) contributes to several pathological processes and is therefore a popular target in the research and development of therapies for certain illnesses.

3 Feb 2010

VEGF Clinical Significance

Vascular endothelial growth factor (VEGF) is a signal protein required for the formation of new blood vessels. Proteins from this family play important roles in various bodily process such as inflammation and wound healing, as well as contributing to disease processes when they are overexpressed.

3 Feb 2010

VEGF Production

VEGF or vascular endothelial growth factor is a signalling molecule that promotes the formation of new blood vessels.

3 Feb 2010

VEGF Mechanism

VEGF or vascular endothelial growth factor is a signalling protein made by cells that stimulates the formation of new blood vessels. There are several different classes of VEGF that play different roles in the body, both in normal bodily process and pathological processes.

3 Feb 2010

VEGF Classification

VEGF (vascular endothelial growth factor) is a signal protein that promotes the growth of new blood vessels. VEGF forms part of the system that restores the blood supply to cells and tissues when they are deprived of oxygenated blood due to compromised blood circulation.

3 Feb 2010

What is VEGF?

Vascular endothelial growth factor (VEGF) is a signalling protein that promotes the growth of new blood vessels. VEGF forms part of the mechanism that restores the blood supply to cells and tissues when they are deprived of oxygenated blood due to compromised blood circulation.

3 Feb 2010

Prokaryotic DNA Polymerases

Prokaryotes contain five different types of DNA polymerase.

11 Jan 2010

DNA Polymerase Families

The DNA polymerases are divided into seven families based on their sequence homology and crystal structure analysis. These include families A, B, C, D, X, Y and RT.

11 Jan 2010

What is DNA Polymerase?

The DNA polymerases are enzymes that create DNA molecules by assembling nucleotides, the building blocks of DNA. These enzymes are essential to DNA replication and usually work in pairs to create two identical DNA strands from one original DNA molecule. During this process, DNA polymerase “reads” the existing DNA strands to create two new strands that match the existing ones.

11 Jan 2010

Stem Cell Patents

Three human embryonic stem cell patents are held by the Wisconsin Alumni Research Foundation (WARF) in the United States. These are based on University of Wisconsin scientist James Thomson’s pioneering research. The US Patent and Trademark Office (USPTO) had granted these patents in 1998 and 2001 (due to expire in 2015 and 2018).

10 Jan 2010