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Novel method creates antibody-peptide inhibitor conjugates with enhanced therapeutic efficacy

Tumor cells often hijack normal physiological processes to support their growth, exploiting proteins that are in charge of essential cell functions.

29 May 2024

Proline-based nano cages offer targeted drug delivery, limit side effects of chemotherapy

A new method of drug delivery using proline, an amino acid found in chicken feathers and skin tissue, could be used to limit the side effects of chemotherapy and repair important enzymes, new research suggests.

29 May 2024

New AI model Dev-ResNet accurately monitors embryonic development in real-time

Research led by the University of Plymouth has shown that a new deep learning AI model can identify what happens and when during embryonic development, from video.

28 May 2024

Scientists design new way to "cloak" proteins for targeted therapeutic delivery

Cornell University scientists have designed a way to "cloak" proteins in a generalized technique that could lead to repurposing things like antibodies for biological research and therapeutic applications.

28 May 2024

MUSC researchers unravel the mystery of cancer recurrence

MUSC Hollings Cancer Center researchers have unlocked a discovery that could help to explain why cancer can recur in patients who have undergone chemotherapy or radiotherapy.

28 May 2024

Underappreciated set of enzymes connected to the regulation of hippo pathway in cancer

Within the family of cell membrane lipids known as phosphoinositides and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have been cast in a starring role as scientists study their involvement in cancer, diabetes and many cellular activities.

28 May 2024

Understanding genetic mosaicism in human cells

In a study led by Jan Korbel at the European Molecular Biology Laboratory (EMBL) and Ashley Sanders at the Berlin Institute for Medical Systems Biology of the Max Delbrück Center (MDC-BIMSB), researchers have found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations – copy number variations and chromosomal rearrangements, for example – without causing any apparent disease or abnormality.

28 May 2024

Novel light-sensitive drug induces sleep without genetic modification

The nucleus accumbens plays a pivotal role in motivational behavior and sleep regulation, modulated by adenosine A2A receptors (A2AR).

28 May 2024

Researchers discover how protein XPD detects and repairs DNA damage

Researchers at the University of Würzburg, led by Caroline Kisker in cooperation with Claudia Höbartner, discovered how the protein XPD detects a severe DNA damage and controls its repair.

28 May 2024

New frontiers in medicine: COVID-19 lessons push for multidisciplinary collaboration

Researchers highlight the need for multidisciplinary collaboration in medicine, especially in addressing transmissible illnesses, precision medicine, and data science, as learned from the COVID-19 pandemic.

28 May 2024

Advanced techniques reveal plectasin's velcro-like action against bacteria

A small antibiotic called plectasin uses an innovative mechanism to kill bacteria. By assembling into large structures, plectasin latches onto its target on the bacterial cell surface comparable to how both sides of Velcro form a bond.

25 May 2024

Two analytical methods developed to analyze several antibiotics in vegetables and earthworms

UPV/EHU researcher Irantzu Vergara has managed to analyze, simultaneously, several families of antibiotics in vegetables and earthworms.

24 May 2024

New small molecule offers hope in combating antibiotic resistance

Researchers from the University of Oxford have developed a new small molecule that can suppress the evolution of antibiotic resistance in bacteria and make resistant bacteria more susceptible to antibiotics.

24 May 2024

Soft X-ray microscope captures living mammalian cells

Researchers have developed a new technique to view living mammalian cells.

24 May 2024

Comprehensive study provides new understandings of genomic influences on neuropsychiatric disease

A new analysis has revealed detailed information about genetic variation in brain cells that could open new avenues for the targeted treatment of diseases such as schizophrenia and Alzheimer's disease.

23 May 2024

UCLA research connects genetic risk and brain changes in autism

A groundbreaking study led by UCLA Health has unveiled the most detailed view of the complex biological mechanisms underlying autism, showing the first link between genetic risk of the disorder to observed cellular and genetic activity across different layers of the brain.

23 May 2024