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Discovery about DNA twists could be crucial in development of new antibiotics

DNA replication is vital to all lifeforms, but in some organisms, it can be prevented by twists in the DNA sequence, called 'supercoils'. If too many supercoils are allowed to build up, cells vital to sustaining life will die.

28 Nov 2018

Study reveals why mitochondria are often strangely shaped inside the brain

Columbia neuroscientists have discovered why mitochondria, tiny power generators that keep our cells healthy, are often strangely shaped inside the brain.

28 Nov 2018

Researchers map cells in the early human placenta to shed light on pregnancy complications

To treat and prevent pregnancy-related disorders, researchers must understand not only what can go wrong, but when. Complications, such as preeclampsia and pre-term birth, often occur in the second or third trimester, and most research to date has focused on those later stages of pregnancy. But the biological events that lead to these problems could start much earlier.

28 Nov 2018

Early-life stress in mice hinders neuron development, causing attention problems

Women are roughly twice as likely as men to develop depression, anxiety and other stress-related problems, including difficulty with attention, and new research from Brown University neuroscientists sheds light on the biological reasons why.

28 Nov 2018

Novel methodology for characterizing neurons could lead to better understanding of brain disease

It takes a lot of cells to make a human brain. The organ houses not only an enormous quantity of neurons (tens of billions), but also an impressive diversity of neuron types. In recent years, scientists have been developing inventories of these cell classes--information that will be essential for understanding how the brain works.

28 Nov 2018

Research reveals how a small molecule helps remove excess cholesterol

Scientists have determined the structure of the activated form of an enzyme that helps to return excess cholesterol to the liver, a study in eLife reports.

27 Nov 2018

Microbiologists uncover how antibiotics help spread resistance

Bacteria can become insensitive to antibiotics by picking up resistance genes from the environment. Unfortunately for patients, the stress response induced by antibiotics activates competence, the ability of cells to take up and integrate foreign DNA, in microorganisms.

27 Nov 2018

Scientists pinpoint protein that plays key role in synovial sarcoma tumors

Researchers have pinpointed a protein that plays a key role in a type of rare cancer often leading to tumours around joints and tendons, according to new findings in eLife.

27 Nov 2018

Using Pre-Clinical Imaging to Detect Cancer

In this interview, Émilie Beaulieu Ouellet, Application Scientist for life science imaging at Photon Etc talks to New-Medical about their range of preclinical infrared imagers and how they can allow cancer detection.

From Photon etc. 27 Nov 2018

Discovery could be used to prevent viral infection and autoimmunity

Researchers have discovered that chemical changes to mRNA regulate the production of interferon beta, and hope to exploit this in new treatments.

27 Nov 2018

Scientists discover important hallmark of aging in neuronal cells

MIT researchers have discovered that free radicals cause a build-up of short RNA snippets which could contribute to neuronal ageing and cognitive decline.

27 Nov 2018

Scientists report novel combination transport system in E. coli

A general concept in biology is that cells use two different systems to transport substances across their membrane: selective pores, which allow passive transport driven by a concentration gradient, and active transport complexes, which use energy to transport substances against a gradient.

27 Nov 2018

New platform for metagenomic analysis

A team of developers from Skolkovo, ITMO University and MIPT presented an online service called Knomics-Biota, which allows for a comprehensive study of intestinal microbiome genetic data.

27 Nov 2018

CytoReason announces publication of new model for translating data from mouse models to human disease

CytoReason, developer of the world's first machine learning platform for human immune system cell-level simulation, today announces publication of a groundbreaking new model for translating data from mouse models to human disease.

27 Nov 2018

ASHG reaffirms cautious but proactive approach recommended in its 2017 position statement on germline genome editing

Given this morning's reports of infants possibly born in China whose genomes were edited by CRISPR-based technology, the American Society of Human Genetics (ASHG) reaffirms the cautious but proactive approach recommended in its 2017 position statement on human germline genome editing, published in The American Journal of Human Genetics.

26 Nov 2018

Microglia show distinct responses under inflammatory conditions

The NorLux Neuro-Oncology Laboratory at LIH's Department of Oncology conducts research on brain diseases, with a special emphasis on glioma biology, drug resistance and systems approaches.

26 Nov 2018

International study of ADHD at genomic scale

An international study, focused on the analysis of the genome of more than 50,000 people worldwide, has identified twelve specific fragments of DNA related to the vulnerability of the attention deficit hyperactivity disorder.

26 Nov 2018

A Preclinical Solution to Studying Neurological Diseases

At SfN 2018, Antti Nurmi explained a case study of how Charles River have used neuroimaging to study Batten's Disease.

From Charles Rivers Laboratories Neuroscience 26 Nov 2018

Study finds genetic links between alcohol dependence and psychiatric disorders

In the largest study of genetic factors linked to alcohol dependence, an international team of researchers identified a gene known to affect risk, and they determined that many other genes also contribute to risk for alcohol dependence to a lesser degree.

26 Nov 2018

Researchers discover new biosynthetic pathway to antibiotics using gene editing

Scientists have discovered a new chemical process - also known as a biosynthetic pathway - in bacteria which could lead to a new generation of antibiotics being produced and manufactured.

26 Nov 2018