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Understanding the complexities of epigenetic aging clocks in health research

A new editorial was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 14 on July 17, 2024, entitled, "Recalibrate concepts of epigenetic aging clocks in human health."

14 Aug 2024

Study reveals how chromatin structure influences social behavior in dogs

A new study on dogs found that chromatin's spatial structure has a significant role in the evolution of social behavior.

14 Aug 2024

DeNovix releases new CellDrop model and applications

DeNovix announces the release of the new CellDrop FLi Automated Cell Counter, the latest update to the popular CellDrop range.

From DeNovix Inc. 14 Aug 2024

Study finds no clinically useful biomarkers for long COVID in routine lab tests

Whether tests in current use were adequate to identify post-acute sequelae of SARS-CoV-2 (PASC).

14 Aug 2024

Revolutionising organoid manufacturing: Monmouth Scientific Class 2 Biological Safety Cabinets enhance sterility and efficiency at Molecular Devices' new Life Science facility.

Global life science and 3D biology pioneers Molecular Devices has launched a groundbreaking facility in Cardiff, dedicated to research, development and industrial-scale manufacture of organoids.

From Monmouth Scientific 14 Aug 2024

New findings reveal how serotonin shapes behavior in negative situations

Researchers increased synaptic serotonin through a selective serotonin-releasing agent, fenfluramine, to investigate its impact on human behavior.

14 Aug 2024

Breakthrough in synthesizing complex plant molecules

MIT chemists have developed a new way to synthesize complex molecules that were originally isolated from plants and could hold potential as antibiotics, analgesics, or cancer drugs.

14 Aug 2024

New targets for improved cancer immunotherapy

In the past two decades, immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, showing promising results against various solid tumors. This study reviews recent developments in ICIs, focusing on new targets like T cell immunoreceptors with Ig and ITIM domains (TIGIT), T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), and lymphocyte activation gene-3 (LAG-3). These targets aim to overcome resistance mechanisms limiting the effectiveness of current therapies, such as anti-PD-1 and anti-CTLA-4. By identifying and developing these new ICIs, researchers hope to improve treatment outcomes and provide new therapeutic options for cancer patients.

14 Aug 2024

Novel vaccination strategy shows promise in boosting immunity and controlling influenza spread in pigs

Study demonstrates that a novel prime/boost vaccination protocol using live-attenuated influenza vaccines effectively induces strong immune responses in pigs, offering a promising approach for future influenza vaccination strategies.

13 Aug 2024

Researchers discover a novel pathway to wake up dormant neural stem cells

Scientists from Duke-NUS Medical School and the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) have discovered a novel pathway to wake up dormant neural stem cells, offering potential new therapies for neurodevelopmental disorders such as autism, learning disabilities, and cerebral palsy.

13 Aug 2024

New insights into lipid-induced senescence in dopaminergic neurons

A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 14 on July 19, 2024, entitled, "Lipid accumulation drives cellular senescence in dopaminergic neurons."

13 Aug 2024

Largest multi-omics study identifies new genetic landscapes in colorectal cancer

The Institute of Intelligent Medical Research (IIMR) of BGI Genomics, in collaboration with Sweden's Uppsala University, has published the largest multi-omics study of colorectal cancer (CRC) to date.

13 Aug 2024

Mrc1 protein identified as key to maintaining cell identity during division

In a major scientific breakthrough, researchers have found that a protein called Mrc1 plays a crucial role in ensuring that cells keep their identity as they divide and grow.

13 Aug 2024

McGill discovery offers hope for targeted stem cell treatments

A new technique developed by McGill researchers for mechanically manipulating stem cells could lead to new stem cell treatments, which have yet to fulfill their therapeutic potential.

13 Aug 2024

Generative AI in genetics: Effective but needs monitoring for consistency

Samuel (Sandy) Aronson, ALM, MA, executive director of IT and AI Solutions for Mass General Brigham Personalized Medicine and senior director of IT and AI Solutions for the Accelerator for Clinical Transformation, is the corresponding author of a paper published in NEJM AI that looked at whether generative AI could hold promise for improving scientific literature review of variants in clinical genetic testing.

13 Aug 2024

AlphaFold accelerates discovery of potential antipsychotic drugs by outperforming traditional methods

Researchers used AlphaFold and homology modeling to identify potent TAAR1 agonists, showing AlphaFold's superior performance in drug discovery for neuropsychiatric conditions.

13 Aug 2024

Cell adhesion and starvation found to be key drivers of pattern formation in keratinocytes

Cell-cell adhesion-induced patterning in keratinocytes can be explained by just starvation and strong adhesion, Hokkaido University researchers find.

12 Aug 2024

Researchers develop new method to study critical type of protein modification process

Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability.

12 Aug 2024

New research identifies key protein complex in cellular quality control

Anyone who's tried to neatly gather a fitted sheet can tell you: folding is hard. Get it wrong with your laundry and the result can be a crumpled, wrinkled mess of fabric, but when folding fails among the approximately 7,000 proteins with an origami-like complexity that regulate essential cellular functions, the result can lead to one of a multitude of serious diseases ranging from emphysema and cystic fibrosis to Alzheimer's disease.

12 Aug 2024

New genomic predictors of relapse in childhood B-cell acute lymphoblastic leukemia uncovered

Scientists from St. Jude Children's Research Hospital, Seattle Children's and the Children's Oncology Group (COG) have identified novel genetic variations that influence relapse risk in children with standard risk B-cell acute lymphoblastic leukemia (SR B-ALL), the most common childhood cancer.

12 Aug 2024