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Researchers uncover why the TP53 gene is especially prone to mutations in cancer

Mutations in the fragile TP53 gene impair p53's tumor-suppressive functions, making it more vulnerable than other tumor suppressors.

24 Oct 2024

Researchers decode MRSA biofilm structure to combat antibiotic resistance

Imagine falling seriously ill with an infection. Normally, we visit the doctor, are prescribed antibiotics, and after 7-10 days, we're back on our feet.

24 Oct 2024

Gene named after Irish folklore may aid recovery from nerve injuries

The key to recovering from traumatic nerve injuries, like those sustained in motor vehicle accidents or gunshot wounds, may be a gene named for the land of everlasting youth in Irish folklore.

24 Oct 2024

Research uncovers new insights into neuronal aging and rejuvenation

When a neuron ages, it loses synaptic connections with other neurons, it is less able to transmit nerve impulses, and its metabolism is also altered. This process of neuronal aging — inevitable with the passing of time — is particularly accelerated and becomes a risk factor in neurodegenerative pathologies such as Alzheimer's disease.

24 Oct 2024

Study reveals hormone receptors' role in brain health and neuroprotection

In a comprehensive review published in the October 2024 issue of Genomic Psychiatry, researchers have unveiled crucial insights into how two types of hormone receptors collaborate to maintain brain health and potentially prevent neurodegenerative diseases.

24 Oct 2024

Study identifies key blood stem cells in immune system aging

What keeps some immune systems youthful and effective in warding off age-related diseases? In a new paper published in Cellular & Molecular Immunology, USC Stem Cell scientist Rong Lu and her collaborators point the finger at a small subset of blood stem cells, which make an outsized contribution to maintaining either a youthful balance or an age-related imbalance of the two main types of immune cells: innate and adaptive.

24 Oct 2024

PIONEER software breaks down barriers in protein-protein interaction research

Scientists from Cleveland Clinic and Cornell University have designed a publicly-available software and web database to break down barriers to identifying key protein-protein interactions to treat with medication.

24 Oct 2024

Researchers identify mechanism of immune suppression in ovarian cancer

Weill Cornell Medicine researchers have discovered a mechanism that ovarian tumors use to cripple immune cells and impede their attack—blocking the energy supply T cells depend on. The study, published Oct. 23 in Nature, points toward a promising new immunotherapy approach for ovarian cancer, which is notoriously aggressive and hard to treat.

24 Oct 2024

3D-printed model created to mimic cancer metastasis

Scientists have created a 3D-printed model to mimic the specific conditions that spur the spread of cancer cells.

23 Oct 2024

Researchers create mini-brains to study autism and test new treatments

Using stem cells generated from patients with a rare and severe form of autism spectrum disorder and intellectual disability, Scripps Research scientists have grown personalized "mini-brains" (or organoids) to study the disorder in new detail.

23 Oct 2024

Southwest Research Institute breaks ground on new clinical supply facility

Southwest Research Institute broke ground today on a new 21,000-square-foot Clinical Supply Facility to support government and industry clients with integrated pharmaceutical and bioengineering research and development.

23 Oct 2024

PacBio Onso™ short read sequencing instrument joins 10X Genomics compatible partner program

PacBio (PACB), a leading developer of high-quality, highly accurate genomic sequencing solutions, today announced the inclusion of the Onso short-read sequencing platform in the 10x Genomics Compatible Partner Program.

From PacBio 23 Oct 2024

Study connects brain volume variations with genetic risk factors for Parkinson’s disease and ADHD

Unprecedented genome analysis reveals genetic links between brain structure and disorders like Parkinson's and ADHD, paving the way for innovative treatments.

23 Oct 2024

Human midbrain organoids: A promising tool in the fight against Parkinson's disease

Advancements in organoid technology are crucial for Parkinson's disease research, providing human-relevant models for studying disease and testing therapies.

23 Oct 2024

Structural biology reveals secrets of DEV phage infection

The viruses that infect bacteria are the most abundant biological entities on the planet. For example, a recent simple study of 92 showerheads and 36 toothbrushes from American bathrooms found more than 600 types of bacterial viruses, commonly called bacteriophages or phages.

22 Oct 2024