Life Science White Papers

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Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in life science research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

APOLLO Raman Microspectrometer for Pharmaceutical Monitoring

Pharmaceutical monitoring is an integral part of the production, testing and manufacturing process.

From CRAIC Technologies, Inc. 3 Apr 2014

Solid-state ChIP Platform for High Throughput Analysis of Gene Regulation

In recent years, epigenetics has become an increasingly important focus in the worlds of academia and industry as researchers try to better understand the fundamental s of transcription regulation. Developments in high throughput ChIP together with the use of automated liquid handing and next generation sequencing is laying the foundations for analysis of global gene expression and understanding the epigenetic landscape in a huge number of cell types across a variety of diseases and treatments.

From Chromatrap® - Porvair Sciences Ltd 19 Mar 2014

Chromatrap 96 High Throughput ChIP for Screening Multiple Epigenetic Targets

Advancements in the field of epigenetics are rapidly growing as researchers elucidate the principles controlling gene regulation via the in vivo binding of proteins to DNA. A major aspect in this is the need to study a vast number of regulatory mechanisms to map interactions between DNA and protein following disease and pathogen stimulus.

From Chromatrap® - Porvair Sciences Ltd 17 Mar 2014

Chromatrap Immunoprecipitation Assay Enriches Epigenetic Histone Methylation Marks from Primary Biopsy Samples

The uterus is a pear-shaped organ that consists of a lower barrel shaped cervix and a large upper body with the 'fundus' over the uterine tubes. It has a thick muscular wall, which houses the human fetus from conception to birth.

From Chromatrap® - Porvair Sciences Ltd 17 Mar 2014

Chromatrap® Technology for Studying Complex Epigenetic Mechanisms

Chromatin immunoprecipitation (ChIP) is a widely used technique for mapping the interactions between intracellular proteins and their DNA targets in gene regulation. The epigenetic mechanisms that affect chromatin formation and control the availability of the DNA backbone to transcription factor regulators is an important area of research. ChIP is a technology that allows researchers a glimpse into the regulatory mechanisms that gene expression.

From Chromatrap® - Porvair Sciences Ltd 17 Mar 2014

Setting Effective Product Specifications in Pharmaceutical Manufacturing

An important aspect of Quality by Design (QbD) is to establish meaningful and realistic specifications. Well-defined specifications control the performance of products, as they derive from associations between clinical behaviour and the variables determined routinely during processing for quality control. This article investigates the process of setting specifications, taking particle size as an example which is a major parameter for a variety of pharmaceutical formulations.

From Malvern Panalytical 17 Mar 2014

Using Ultraviolet Microscopy and Microspectroscopy for Analysis of Red Blood Cells

One of the most important techniques used for analyzing biological materials is UV-visible range microspectroscopy.

From CRAIC Technologies, Inc. 3 Feb 2014

DNA Analysis with UV-Visible Microspectroscopy

In forensics laboratories, one of the most frequently used techniques is DNA analysis with UV-visible microspectroscopy.

From CRAIC Technologies, Inc. 3 Feb 2014

Using Absorbance Microspectroscopy to Analyze Biocrystalline Materials

UV-visible range microspectroscopy is one of the most useful techniques for studying individual protein crystals.

From CRAIC Technologies, Inc. 3 Feb 2014

Darkfield Hyperspectral Imaging for Analysis of Nanoparticles in Cancer Cells

Biological samples typically contain nanomaterials that scatter light significantly, and these samples are usually studied with dark field illumination. When dark field illumination is combined with hyperspectral imaging, it becomes a unique tool that can be used for identifying the location and composition of nanomaterials embedded in cells. To this end, the IMA hyperspectral imager supplied by Photon etc can be used for this application. A high-efficient dark field condenser can be fitted to this hyperspectral imager to produce high contrast images of biological samples.

From Photon etc. 22 Jan 2014

Functional Connectivity Magnetic Resonance Imaging of the Rat Brain

Over the last 15 years, functional magnetic resonance imaging (fMRI) of the brain's "resting state" (rsfMRI) and its measures of functional connectivity have been major topics of interest.

From Bruker BioSpin - NMR, EPR and Imaging 1 Dec 2013

Onsite Laboratories

Analytical laboratories have a responsibility to successfully execute qualitative and quantitative analysis on potential drug discoveries. These testing labs have an important role in the clinical trial drug process, providing the pharmaceutical industry with the necessary data during the drug development process.

From Packaging Coordinators Inc. (PCI) 3 Oct 2013

Importance of Convergence in the Pharmaceutical Market

In recent years, convergence has been playing a significant role in the growth of the pharmaceutical market and applies to several aspects of the market, including cosmecutical, nutraceutical, veterinary and the over the counter (OTC) markets.

From Packaging Coordinators Inc. (PCI) 16 Sep 2013

Development of Customized Packaging Facility for Safe and Effective Packaging of Cytotoxic Compounds

Cytotoxic compounds are mainly utilized in oncology to treat cancerous cells; however, these substances present unique environmental and safety issues because of their highly toxic nature. As a result of these challenges, cytotoxic drugs must be packed safely and securely as even the smallest amount of exposure can pose a major threat to the human body.

From Packaging Coordinators Inc. (PCI) 16 Sep 2013

Developing a Standardised Identification Solution for Pharmaceutical Counterfeiting

With recent reports addressing the vulnerability of the pharmaceutical industry to counterfeiting, the security of the pharmaceutical supply chain is a matter of growing concern. The practice of counterfeiting can place significant burdens on the economy.

From Packaging Coordinators Inc. (PCI) 16 Sep 2013

Adaptive Clinical Trials for Overcoming Research Challenges

Over the last five years, there has been a major concern within the pharmaceutical industry relating to the rising costs of research and development, along with a reduced number of new drugs introduced into the market. To deal with these issues, adaptive clinical trial designs are being increasingly used to save both time and money and also to facilitate effective decision making.

From Packaging Coordinators Inc. (PCI) 16 Sep 2013