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Domainex, Sigma-Aldrich enter collaboration to study epigenetic proteins

Domainex Ltd., the Contract Research Organization committed to excellence in drug discovery, today announced a collaboration with Sigma-Aldrich that will provide essential tools, including biochemical assays and monoclonal antibodies, for the study of proteins involved in the rapidly developing field of epigenetics. These epigenetic proteins regulate DNA expression and can be critical to cancer and stem cell biology research. Funding from the UK Government-backed Technology Strategy Board will support this work.

15 Nov 2010

CEVEC establishes North American subsidiary in Maryland, USA

CEVEC Pharmaceuticals, the developer of a novel human protein expression system derived from amniocytes, announced today the US expansion of it's business by founding a North American subsidiary, CEVEC Pharmaceuticals, Inc., in Potomac, Maryland, USA.

15 Nov 2010

Oregon scientist investigates safety, effectiveness of novel low-cost family-planning option

The Bill & Melinda Gates Foundation has awarded nationally prominent Oregon Health & Science University reproductive scientist Jeffrey T. Jensen, M.D., M.P.H., a $100,000 grant to investigate the safety and effectiveness of a novel low-cost family-planning option that may be applicable to women in low-resource countries worldwide.

15 Nov 2010

Vit D deficiency does not raise stroke risk in African-Americans

While vitamin D deficiency is associated with fatal stroke among whites, it is not linked to more stroke deaths among blacks, according to research presented at the American Heart Association's Scientific Sessions 2010.

15 Nov 2010

Researchers find structural deficits in gray matter may be associated with daytime sleepiness

Patients with obstructive sleep apnea (OSA) may blame their daytime difficulties on simple sleepiness, but new research suggests that their brains may be to blame. Specifically, their cognitive challenges may be caused by structural deficits in gray matter, brought on by the intermittent oxygen deprivation that comes with OSA. The good news is that these deficits may be partially or fully reversible with early detection and treatment, according to Italian researchers

15 Nov 2010

Report documents increase in R&D projects on developing world diseases

Drugmakers are now working on over 100 R&D projects designed to tackle diseases of the developing world and almost 80% of them are being carried out with non-industry partners, according to a report released on Wednesday by the International Federation of Pharmaceutical Manufacturers & Associations (IFPMA).

15 Nov 2010

Scientists find sleep helps consolidate memories

Scientists have found that sleep helps consolidate memories, fixing them in the brain so we can retrieve them later. Now, new research is showing that sleep also seems to reorganize memories, picking out the emotional details and reconfiguring the memories to help you produce new and creative ideas, according to the authors of an article in Current Directions in Psychological Science, a journal of the Association for Psychological Science.

15 Nov 2010

Research may lead to new treatment options for spinal cord injuries

A study led by researchers in the Department of Neurosciences at the University of California, San Diego School of Medicine shows unexpected and extensive natural recovery after spinal cord injury in primates. The findings, to be published November 14 in the advance online edition of Nature Neuroscience, may one day lead to the development of new treatments for patients with spinal cord injuries.

15 Nov 2010

Scientists uncover DNA sequence variations associated with cardiac electrical activity

Scientists studying genetic data from nearly 50,000 people have uncovered several DNA sequence variations associated with the electrical impulses that make the heart beat. The findings, reported in Nature Genetics, may pave the way for a greater understanding of the mechanisms for abnormal heart rhythms and sudden cardiac death.

15 Nov 2010

State roundup: Calif. speeds ahead on health reform; Nebraska abortion provider expanding clinics; Ky. hospital merger

California has moved quickly to implement key provisions of the federal health care overhaul law, including a health benefits exchange, but the exchange and California's plans could be vulnerable as House Republicans threaten to starve the federal health program of funding.

15 Nov 2010

Obese children with congenital heart disease face risk of heart disease as adults

Children with congenital heart disease are more overweight than similar children a generation ago, raising their risk of heart attack and heart disease as adults, according to a new study.

15 Nov 2010

Researchers find link between genetic defect and sticky mucus in cystic fibrosis

An imbalance of salt and water in patients with cystic fibrosis makes their lungs clog up with sticky mucus that is prone to infection. The cause of the offending imbalance is a well-known genetic error, one that blocks the molecular expressway for tiny chloride ions to move across the surface of the lungs.

15 Nov 2010

States and providers threaten to drop Medicaid; shortage of providers threatens Medicaid managed-care networks

After Republicans in the Texas legislature floated a radical cost-saving proposal to opt out of Medicaid last week, experts are trying to determine how serious they are, and whether other states are likely to follow suit, Kaiser Health News reports.

15 Nov 2010

Long-term care: MetLife dropping policies, NFL union rejects management offer

MetLife Inc. said it will halt sales of long-term-care insurance, a type of coverage that repeatedly has flummoxed insurers and forced some to pay significantly more in claims than they expected.

15 Nov 2010

New findings on HIV can help validate structure-based drug design approach

The development of new drugs to treat and prevent HIV/AIDS depends on understanding the basic biology of how the virus infects human cells. For 25 years, researchers supported primarily by NIH's National Institute of General Medical Sciences (NIGMS) have been generating the structures of key viral proteins, revealing important insights into the virus's mechanisms and, more importantly, its Achilles' heels.

15 Nov 2010

Research on E.Coli bacteria could help develop new vaccine for urinary tract infection

Urinary tract infections are a painful, recurring problem for millions of women. They are also getting more dangerous as bacteria develop resistance to the most common treatments.

15 Nov 2010

Governors line up against the health overhaul

In Wisconsin, Republican Governor-elect Scott Walker asked [Democratic] Gov. Jim Doyle Thursday to freeze his administration's push on high-profile issues ranging from the implementation of the federal health care law to a costly upgrade of a state power plant until Walker takes office on Jan. 3.

15 Nov 2010

Researchers improvise fruit fly as a model system to study brain development, disorders

VIB researchers attached to the K.U.Leuven have improved the fruit fly as a model for studying the connections between brain cells. The researchers developed a specific marker for a part of the fly's nerve cell which had previously been difficult to distinguish. Their discovery will not only contribute to gaining a better insight into brain development but also makes the fruit fly into a better model system for studying brain development and brain disorders.

15 Nov 2010

POZEN presents PA32540 Phase 1 study results for cardiovascular disease at AHA Session

POZEN Inc., a pharmaceutical company committed to transforming medicine that transforms lives, announced today the results of a Phase 1 study, which reported that PA32540, a novel coordinated-delivery tablet of enteric-coated aspirin (325 mg) and immediate-release omeprazole (40 mg), showed no ex vivo drug-drug interaction with clopidogrel when administered 10 hours apart in healthy patients, based on the study's pre-specified analysis.

15 Nov 2010

Drug industry: Pharmaceutical companies find ways to cope as patents expire; FDA criticized for consulting contracts

There is a simple explanation for most of the mergers and acquisitions in the pharmaceutical world these days the so called Patent Cliff. Simply put, many of the drug industry's biggest earners blockbuster medications that have paid the bills for the last decade are about to lose their patent protections.

15 Nov 2010

Medical News

Domainex, Sigma-Aldrich enter collaboration to study epigenetic proteins

CEVEC establishes North American subsidiary in Maryland, USA

Oregon scientist investigates safety, effectiveness of novel low-cost family-planning option

Vit D deficiency does not raise stroke risk in African-Americans

Researchers find structural deficits in gray matter may be associated with daytime sleepiness

Report documents increase in R&D projects on developing world diseases

Scientists find sleep helps consolidate memories

Research may lead to new treatment options for spinal cord injuries

Scientists uncover DNA sequence variations associated with cardiac electrical activity

State roundup: Calif. speeds ahead on health reform; Nebraska abortion provider expanding clinics; Ky. hospital merger

Obese children with congenital heart disease face risk of heart disease as adults

Researchers find link between genetic defect and sticky mucus in cystic fibrosis

States and providers threaten to drop Medicaid; shortage of providers threatens Medicaid managed-care networks

Long-term care: MetLife dropping policies, NFL union rejects management offer

New findings on HIV can help validate structure-based drug design approach

Research on E.Coli bacteria could help develop new vaccine for urinary tract infection

Governors line up against the health overhaul

Researchers improvise fruit fly as a model system to study brain development, disorders

POZEN presents PA32540 Phase 1 study results for cardiovascular disease at AHA Session

Drug industry: Pharmaceutical companies find ways to cope as patents expire; FDA criticized for consulting contracts

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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