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Key enzyme identified as potential target for cancer treatment

During every moment of any living organism's life, enzymes are at work. These crucial proteins support life through most biological processes, including metabolism, movement, respiration, and digestion.

14 Sep 2024

New cancer drug shows encouraging results in Phase I/II trial

The antibody-drug conjugate (ADC) puxitatug samrotecan (AZD8205) demonstrated a manageable safety profile consistent with similar ADCs and initial efficacy in heavily pretreated patients with advanced or metastatic solid tumors, according to interim data shared today at the 2024 European Society for Medical Oncology (ESMO) Congress by researchers from The University of Texas MD Anderson Cancer Center.

14 Sep 2024

Innovative heart valve technology could improve patient lives

Now, a team of UBC Okanagan researchers believe they have found a way to harness the strengths of both technologies in a way that could be life-changing-;and life-saving-;for many. Dr. Hadi Mohammadi and his fellow researchers in the Heart Valve Performance Laboratory at UBC Okanagan are focused on developing the mechanical heart valves of the future.

14 Sep 2024

Researchers seek early Alzheimer's detection with MRSI

University of Virginia professor Mathews Jacob has secured a $3.9 million grant to advance his innovative research on detecting Alzheimer's disease in its early stages. Jacob, who specializes in electrical and computer engineering, is teaming up with researchers from the University of Iowa and the University of California-San Francisco to push the boundaries of imaging technology that tracks the brain's metabolic changes -; offering a fresh perspective on studying neurodegenerative disorders.

14 Sep 2024

Study identifies common misuses of spike-in normalization

Researchers at University of California San Diego have published new guidelines that could help scientists significantly improve their results when quantifying the interactions between DNA and proteins. Understanding these interactions is critical to our understanding of human biology in general, and can also help scientists develop new treatments for a wide range of diseases, including many cancers.

14 Sep 2024

AI-powered treatment allocation improves public health outcomes

A new study sheds light on a promising approach using machine learning to more effectively allocate medical treatments during a pandemic or any time there's a shortage of therapeutics.

14 Sep 2024

Scientists develop novel technique to combat T cell exhaustion

Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion. This phenomenon also hinders adoptive cell therapies, in which healthy, tumor-targeting T cells are infused into patients with cancer. A novel method to boost mitochondrial activity and charge up T cells is needed.

14 Sep 2024

Mount Sinai researchers uncover genetic basis of fibromuscular dysplasia

Mount Sinai researchers have identified a key driver of a blood vessel disorder known as fibromuscular dysplasia (FMD) which affects up to five percent of the adult population and can lead to high blood pressure, heart attack, or stroke.

14 Sep 2024

Microbiome science could revolutionize fight against malnutrition

OpenBiome, a pioneering nonprofit microbiome health organization, will explore the dramatic growth of microbiome science and its potential as a game-changing solution for malnutrition during its session "Why the Gut Microbiome is Critical to Children's Health: Harnessing Microbiome Science to End Malnutrition" on September 25, 2024, at the Science Summit at the UN General Assembly.

14 Sep 2024

Scientists develop selective therapy for tau tangles

Scientists have developed new potential therapies that selectively remove aggregated tau proteins, which are associated with Alzheimer's disease, and improve symptoms of neurodegeneration in mice.

14 Sep 2024

New insight into the causes of autoimmune diseases

Autoimmune diseases are widespread and notoriously difficult to treat. In part, this is because why the immune system attacks its own tissues in patients with these conditions remains poorly understood.

14 Sep 2024

High-pressure homogenization stabilizes paprika oleoresin

Paprika oleoresin (PO), extracted from chili peppers, is renowned for its vibrant color and beneficial health properties, such as antioxidant and anti-inflammatory effects. However, its lipophilic nature and sensitivity to factors like oxygen, heat, and light restrict its use in water-based foods. While previous approaches, including emulsions and liposomes, have aimed to improve PO's stability, the results have been limited. These persistent challenges underscore the need for new stabilization methods for PO.

14 Sep 2024

Study finds e-cigarette ads on social media often misleading

Island breeze, blue lagoon, dew drop-;these aren't the names of scented candles on display at your local home goods store. They're flavors of synthetic nicotine used in e-cigarettes, often advertised with neon-electric colors and bright lettering to make them look like boxes of candy or fruit juice. But underneath all the flair, a specific label written clearly in black text on a white background is required by law to be there: a warning that says the product contains nicotine and that nicotine is an addictive substance.

14 Sep 2024

Flow Robotics and Global Focus announce distribution partnership in USA

Flow Robotics, Copenhagen, Denmark and Global Focus, Dallas, Texas, will bring the liquid handler, flowbot® ONE, and other products to labs throughout USA.

From Flow Robotics 14 Sep 2024

Real-world data reveals factors associated with long-term weight loss in obesity

A Cleveland Clinic study identified key factors that can impact the long-term weight loss of patients with obesity who were prescribed injectable semaglutide or liraglutide for the treatment of type 2 diabetes or obesity. The study was published in JAMA Network Open.

14 Sep 2024

Evolution of vaccine adjuvants from empirical discovery to rational design

Vaccine adjuvants have evolved significantly since their inception, transitioning from empirical discovery to a more structured approach grounded in rational drug design.

13 Sep 2024

Study reveals how SARS-CoV-2 triggers diabetes by destroying pancreatic cells

Researchers from Weill Cornell Medicine have used a cutting-edge model system to uncover the mechanism by which SARS-CoV-2, the virus that causes COVID-19, induces new cases of diabetes, and worsens complications in people who already have it.

13 Sep 2024

New drug shows strong activity against brain metastases in HER2-positive breast cancer

A drug that delivers chemotherapy directly to tumors has shown impressive activity against some of the hardest-to-reach cancer cells: those that have spread to the brain in patients with advanced HER2-positive breast cancer.

13 Sep 2024

Study sheds light on potential demand for psilocybin-assisted therapy for depression in the U.S.

In the wake of mounting evidence for the efficacy of psychedelic-assisted therapies, the U.S. Food and Drug Administration (FDA) is considering approving psilocybin, the active ingredient in "magic mushrooms," for treating depression in the near future.

13 Sep 2024

Over a third of UK medical graduates lack training on sexual misconduct

More than a third of newly qualified doctors are leaving UK medical schools without any education on sexual misconduct specifically relating to the medical profession according to new research published by JRSM Open.

13 Sep 2024